Pursuant to a Congressional act in 2008, the Department of Health and Human Services established the Interagency Breast Cancer and Environmental Research Coordinating Committee to address the burden of breast cancer in the United States. Subsequently, the Committee recommended researchers study the timing of exposure to breast cancer risk factors. Given the high breast cancer mortality rate on Staten Island, this paper presents a case-control study investigating breast cancer risk associated with puberty while living on Staten Island. The dataset combined New York City Department of Health and Mental Hygiene female death certificate information between 1985 and 2006, with life history information from newspaper obituaries. Data analyzed included: age, length of residence on Staten Island, birth on Staten Island, and residence on Staten Island during puberty. Cases were individuals who died of breast cancer and controls were individuals who died of non-malignant causes. Analysis included multivariate logistic regression on the full dataset and multiple replicates of randomized one case to two controls simulations. Results indicated that living on Staten Island during puberty (ages 9–19) was associated with an elevated risk of dying from breast cancer (odds ratio 1.35, p < 0.001, 95% CI = 1.18, 1.55). This paper suggests the importance of studying puberty as a window of susceptibility for breast cancer risk.
Citation: Alfred M Levine, Donna B Gerstle. Female breast cancer mortality in relation to puberty on Staten Island, New York[J]. AIMS Public Health, 2020, 7(2): 344-353. doi: 10.3934/publichealth.2020029
Pursuant to a Congressional act in 2008, the Department of Health and Human Services established the Interagency Breast Cancer and Environmental Research Coordinating Committee to address the burden of breast cancer in the United States. Subsequently, the Committee recommended researchers study the timing of exposure to breast cancer risk factors. Given the high breast cancer mortality rate on Staten Island, this paper presents a case-control study investigating breast cancer risk associated with puberty while living on Staten Island. The dataset combined New York City Department of Health and Mental Hygiene female death certificate information between 1985 and 2006, with life history information from newspaper obituaries. Data analyzed included: age, length of residence on Staten Island, birth on Staten Island, and residence on Staten Island during puberty. Cases were individuals who died of breast cancer and controls were individuals who died of non-malignant causes. Analysis included multivariate logistic regression on the full dataset and multiple replicates of randomized one case to two controls simulations. Results indicated that living on Staten Island during puberty (ages 9–19) was associated with an elevated risk of dying from breast cancer (odds ratio 1.35, p < 0.001, 95% CI = 1.18, 1.55). This paper suggests the importance of studying puberty as a window of susceptibility for breast cancer risk.
| [1] | (2012) Gale Virtual Reference LibraryProfiles of New York State 2012–2013. New York: Grey House Publishing 329-330. |
| [2] | United States Census Bureau (2017) Richmond County (Staten Island Borough), New York. Available from: https://www.census.gov/quickfacts/fact/table/bronxcountybronxboroughnewyork,queenscountyqueensboroughnewyork,newyorkcountymanhattanboroughnewyork,kingscountybrooklynboroughnewyork,richmondcountystatenislandboroughnewyork/PST045217. |
| [3] | State of New York (1882) IN ASSEMBLY No. 9. Available from: https://books.google.com/books?id=eXt2Ld9JWQ4C&pg=PP7&lpg=PP7&dq=%22state+of+new+york%22+%22in+assembly%22+February+8,+1882&source=bl&ots=c6xhJMLhYW&sig=ACfU3U12-cZuduolFPhznUqMhaBFWMQJ0w&hl=en&sa=X&ved=2ahUKEwjy-52UkuvpAhXqhXIEHY5aCNoQ6AEwAXoECAkQAQ#v=onepage&q=%22state%20of%20new%20york%22%20%22in%20assembly%22%20February%208%2C%201882&f=false. |
| [4] | State of New York (1883) IN ASSEMBLY No. 110. Available from: https://www.google.com/books/edition/Annual_Report_of_the_State_Board_of_Heal/44gXAQAAIAAJ?hl=en&gbpv=1&dq=%22state+of+new+york%22+%22in+assembly%22+March+12+1883&pg=PA1&printsec=frontcover. |
| [5] | New York State Board of Health (1883) Report on Stench-Nuisances from Oil Refinery near the Kill Von Kull. Available from: https://www.google.com/books/edition/Annual_Report_of_the_State_Board_of_Heal/44gXAQAAIAAJ?hl=en&gbpv=1&dq=%22state+of+new+york%22+%22in+assembly%22+March+12+1883&pg=PA1&printsec=frontcover. |
| [6] | Meyers J (1928) Cancer Death-Rate Variations in Relation to Combustion Products of Fuel, Topography and Population. N Y State J Med 28: 365-372. |
| [7] |
Greenberg L, Field F, Reed J, et al. (1967) Air Pollution and Cancer Mortality: Study on Staten Island (Borough of Richmond), New York. Arch Environ Health 15: 356-361. doi: 10.1080/00039896.1967.10664931
|
| [8] | United States Environmental Protection Agency (1993) Staten Island/New Jersey Urban Air Toxics Assessment Project Report v.2. Description of the Project. Available from: https://nepis.epa.gov/Exe/ZyPDF.cgi/9101NPQL.PDF?Dockey=9101NPQL.PDF. |
| [9] | New York City Department of Environmental Protection (2017) Department of Environmental Protection and NYC Parks Open Brookfield Park after Landfill-to-Park Transformation. Available from: https://www1.nyc.gov/html/dep/html/press_releases/17-109pr.shtml#.XUm2poftzIV. |
| [10] | New York City Parks (2019) Freshkills Park. Available from: https://www.nycgovparks.org/park-features/freshkills-park/about-the-site. |
| [11] | United States Environmental Protection Agency (1982) Inventory of Open Dumps. United States Environmental Protection Agency, Office of Solid Waste. Available from: https://nepis.epa.gov/Exe/ZyPDF.cgi/9101Q5Y0.PDF?Dockey=9101Q5Y0.PDF. |
| [12] | Galusha D (2016) Liquid Assets: A History of New York City's Water System New York: Purple Mountain Press, 123. |
| [13] | (2000) Committee to Review the New York City Watershed Management Strategy, Water Science and Technology Board Commission on Geosciences, Environment, and ResourcesWatershed Management for Potable Water Supply: Assessing the New York City Strategy.National Academy Press. Available from: https://www.nap.edu/read/9677/chapter/1. |
| [14] | (1996) New York City Department of HealthStaten Island cancer incidence study. New York: . |
| [15] | New York City Department of Health (2000) Cancer incidence study addendum: Cancer rates 1989–1992 and cancer trends 1978–1992. Available from: https://www1.nyc.gov/assets/doh/downloads/pdf/environmental/staten-island-cancer-incidence-addendum-2000.pdf. |
| [16] | New York City Department of Health and Mental Hygiene (2019) A descriptive study of cancer and other health outcomes around the former Fresh Kills Landfill, Staten Island. Available from: https://www1.nyc.gov/assets/doh/downloads/pdf/environmental/cancer-and-other-health-outcomes-around-former-fresh-kills-landfill-staten-island.pdf. |
| [17] | New York State Department of Health (2019) Cancer time trends. Available from: https://www.health.ny.gov/statistics/cancer/registry/table2.htm. |
| [18] | Centers for Disease Control and Prevention, Division of Cancer Prevention and Control (2017) Risk factors for breast cancer. Available from: https://www.cdc.gov/cancer/breast/basic_info/risk_factors.htm. |
| [19] | Report of the Interagency Breast Cancer and Environment Research Coordinating Committee (2013) Breast Cancer and the Environment: Prioritizing Prevention. Available from: https://www.niehs.nih.gov/about/assets/docs/breast_cancer_and_the_environment_prioritizing_prevention_508.pdf. |
| [20] |
Watkins D, Sanchez B, Tellez-Rojo M, et al. (2017) Phthalate and bisphenol A exposure during in utero windows of susceptibility in relation to reproductive hormones and pubertal development in girls. Environ Res 159: 143-151. doi: 10.1016/j.envres.2017.07.051
|
| [21] |
Brody J, Moysich K, Humblet O, et al. (2007) Environmental pollution and breast cancer. Cancer 109: 2667-2711. doi: 10.1002/cncr.22655
|
| [22] |
Byrne C, Divekar S, Storchan G, et al. (2013) Metals and breast cancer. J Mammary Gland Biol Neoplasia 18: 63-73. doi: 10.1007/s10911-013-9273-9
|
| [23] |
Rodgers K, Udesky J, Rudel R, et al. (2018) Environmental chemicals and breast cancer: An updated review of epidemiological literature informed by biological mechanisms. Environ Res 160: 152-182. doi: 10.1016/j.envres.2017.08.045
|
| [24] |
Lope V, Garcia-Esquinas E, Perez-Gomez B, et al. (2016) Perinatal and childhood factors and risk of breast cancer subtypes in adulthood. Cancer Epidemiol 40: 22-30. doi: 10.1016/j.canep.2015.11.004
|
| [25] |
Windham G, Pinney S, Voss R, et al. (2015) Brominated flame retardants and other persistent organohalogenated compounds in relation to timing of puberty in a longitudinal study of girls. Environ Health Perspect 123: 1046-1052. doi: 10.1289/ehp.1408778
|
| [26] |
Mauras N, Santen R, Colon-Otero G, et al. (2015) Estrogens and their genotoxic metabolites are increased in obese prepubertal girls. J Clin Endorcrinol Metab 100: 2322-2328. doi: 10.1210/jc.2015-1495
|
| [27] | Jones R, Watson K, Campbell C, et al. (2014) IGF-IR Mediated mammary tumorigenesis is enhanced during pubertal development. PLoS ONE 9: 1-8. |
| [28] |
Lee J, Klimberg S, Bondurant K, et al. (2014) Cross-sectional study to assess the association of population density with predicted breast cancer risk. Breast J 20: 615-621. doi: 10.1111/tbj.12330
|
| [29] |
Osborne G, Rudel R, Schwarzman M (2015) Evaluating chemical effects on mammary gland development: A critical need in disease prevention. Reprod Toxicol 54: 148-155. doi: 10.1016/j.reprotox.2014.07.077
|
| [30] |
Dearth R, Hiney J, Srivastava V, et al. (2015) Prepubertal exposure to elevated manganese results in estradiol regulated mammary gland ductal differentiation and hyperplasia in female rats. Exp Biol Med 239: 871-882. doi: 10.1177/1535370214531865
|
| [31] |
Wolff M, Teitelbaum S, McGovern K, et al. (2014) Phthalate exposure and pubertal development in a longitudinal study of US girls. Hum Reprod 29: 1558-1566. doi: 10.1093/humrep/deu081
|
| [32] |
Biro F, Deardorff J (2013) Identifying opportunities for cancer prevention during preadolescence and adolescence: Puberty as a window of susceptibility. J Adolesc Health 52: 515-520. doi: 10.1016/j.jadohealth.2012.09.019
|
| [33] |
Nichols H, Schoemaker M, Cai J, et al. (2019) Breast cancer risk after recent childbirth: A polled analysis of 15 prospective studies. Ann Int Med 170: 22-30. doi: 10.7326/M18-1323
|
| [34] | Legal Information Institute (2008) Breast Cancer and Environmental Research Act of 2008. Available from: https://www.law.cornell.edu/topn/breast_cancer_and_environmental_research_act_of_2008. |
| [35] | Melmed S, Polonsky K, Larsen P, et al. (2015) Williams Textbook of Endocrinology Pennsylvania: Elsevier Health Sciences, Springer, 1081. |
| [36] | Centers for Disease Control and Prevention (1999) International Classification of Diseases. Available from: https://www.cdc.gov/nchs/icd/icd9cm.htm. |
| [37] | Centers for Disease Control and Prevention (2000) International Classification of Diseases. Available from: https://www.cdc.gov/nchs/icd/icd10cm.htm. |
| [38] | Staten Island Advance (1985–2006) Available from: https://www.silive.com/. |
| [39] | Gerstle D, White K, Levine A (2013) Reliability of obituaries as a data source in epidemiologic studies: Agreement in age, residence and occupation. Available from: https://studylib.net/doc/11010921/science-journal-of-medicine-and-clinical-trials-published. |
| [40] | Lyttle P, Epstein J (1987) Geologic map of the Newark 1 degree by 2 degrees Quadrangle, New Jersey, Pennsylvania, and New York. Available from: https://doi.org/10.3133/i1715. |
| [41] |
Deschamps F, Godard M, Guillot S, et al. (2013) Geochemistry of subduction zone serpentinites: A review. Lithos 178: 96-127. doi: 10.1016/j.lithos.2013.05.019
|
| [42] | Oze C, Fendorf S, Bird D, et al. (2004) Chromium geochemistry of serpentine soils. Serpentine and Serpentinites: Mineralogy, Petrology, Geochemistry, and Tectonics Columbia MD: Bellwether Publishing Co, 339-368. |
| [43] | New York City Parks (2019) Freshkills Park. Available from: https://www.nycgovparks.org/park-features/freshkills-park/about-the-site. |
| [44] | Chapter 107 of the Laws of 1996 (1996) Environmental Conservation Law Section 27-0706. Available from: https://codes.findlaw.com/ny/environmental-conservation-law/env-sect-27-0706.html. |
| [45] | Department of Environmental Conservation (2017) DEC Announces Successful Remediation of Former Brookfield Avenue Landfill. Available from: https://www.dec.ny.gov/press/111121.html. |
| [46] | Appellate Division of the Supreme Court of the State of New York, Second Department (1984) People v. Cassiliano. Available from: https://www.leagle.com/decision/1984909103ad2d8063668. |
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Alfred M Levine, Donna B Gerstle. Female breast cancer mortality in relation to puberty on Staten Island, New York[J]. AIMS Public Health, 2020, 7(2): 344-353. doi: 10.3934/publichealth.2020029
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