Research article

Epidemiology of cancer in Saudi Arabia thru 2010–2019: a systematic review with constrained meta-analysis

Running title: epidemiology of cancer in Saudi Arabia thru 2010–2019
  • Background: Cancer is emerging as a major global health-care system challenge with a growing burden worldwide. Due to the inconsistent cancer registry system in Saudi Arabia, the epidemiology of cancer is still dispersed in the country. Consequently, this review aimed to assemble the epidemiological metrics of cancer in Saudi Arabia in light of the available published data during the period from (2010–2019). Methods: Published literature from Saudi Arabia relating to cancer incidence, prevalence, risk factors, and other epidemiological metrics were accessed through electronic search in Medline/PubMed, Cochrane, Scopus, Web of Knowledge, Google Scholar, and public database that meet the inclusion criteria. Relevant keywords were used during the electronic search about different types of cancers in Saudi Arabia. No filters were used during the electronic searches. Data were pooled and odds ratios (ORs) and 95% confidence interval (95%CI) were calculated. A random-effects meta-analysis was performed to assess the well-determined risk factors associated with different types of cancers. Results: The most common cancers in Saudi Arabia are breast, colorectal, prostate, brain, lymphoma, kidney and thyroid outnumbering respectively. Their prevalence rates and OR (95%CI) as follow: breast cancer 53% and 0.93 (0.84–1.00); colon-rectal cancer (CRC) 50.9% and 1.2 (0.81–1.77); prostate cancer 42.6% and 3.2 (0.88–31.11); brain/Central Nervous System cancer 9.6% and 2.3 (0.01–4.2); Hodgkin and non-Hodgkin’s lymphoma 9.2% and 3.02 (1.48–6.17); kidney cancer 4.6% and 2.05 (1.61–2.61), and thyroid cancer 12.9% and 6.77 (2.34–19.53). Conclusion: Within the diverse cancers reported from Saudi Arabia, the epidemiology of some cancers magnitude 3-fold in the latest years. This increase might be attributed to the changing in the Saudi population lifestyle (adopting western model), lack of cancer awareness, lack of screening & early detection programs, social barriers toward cancer investigations. Obesity, genetics, sedentary lifestyle, tobacco use, viral infection, and iodine & Vit-D deficiency represent the apparent cancer risk factors in Saudi Arabia.

    Citation: Wedad Saeed Alqahtani, Nawaf Abdulrahman Almufareh, Dalia Mostafa Domiaty, Gadah Albasher, Manal Abduallah Alduwish, Huda Alkhalaf, Bader Almuzzaini, Salma Sanhaat AL-marshidy, Rgya Alfraihi, Abdelbaset Mohamed Elasbali, Hussain Gadelkarim Ahmed, Bassam Ahmed Almutlaq. Epidemiology of cancer in Saudi Arabia thru 2010–2019: a systematic review with constrained meta-analysis[J]. AIMS Public Health, 2020, 7(3): 679-696. doi: 10.3934/publichealth.2020053

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  • Background: Cancer is emerging as a major global health-care system challenge with a growing burden worldwide. Due to the inconsistent cancer registry system in Saudi Arabia, the epidemiology of cancer is still dispersed in the country. Consequently, this review aimed to assemble the epidemiological metrics of cancer in Saudi Arabia in light of the available published data during the period from (2010–2019). Methods: Published literature from Saudi Arabia relating to cancer incidence, prevalence, risk factors, and other epidemiological metrics were accessed through electronic search in Medline/PubMed, Cochrane, Scopus, Web of Knowledge, Google Scholar, and public database that meet the inclusion criteria. Relevant keywords were used during the electronic search about different types of cancers in Saudi Arabia. No filters were used during the electronic searches. Data were pooled and odds ratios (ORs) and 95% confidence interval (95%CI) were calculated. A random-effects meta-analysis was performed to assess the well-determined risk factors associated with different types of cancers. Results: The most common cancers in Saudi Arabia are breast, colorectal, prostate, brain, lymphoma, kidney and thyroid outnumbering respectively. Their prevalence rates and OR (95%CI) as follow: breast cancer 53% and 0.93 (0.84–1.00); colon-rectal cancer (CRC) 50.9% and 1.2 (0.81–1.77); prostate cancer 42.6% and 3.2 (0.88–31.11); brain/Central Nervous System cancer 9.6% and 2.3 (0.01–4.2); Hodgkin and non-Hodgkin’s lymphoma 9.2% and 3.02 (1.48–6.17); kidney cancer 4.6% and 2.05 (1.61–2.61), and thyroid cancer 12.9% and 6.77 (2.34–19.53). Conclusion: Within the diverse cancers reported from Saudi Arabia, the epidemiology of some cancers magnitude 3-fold in the latest years. This increase might be attributed to the changing in the Saudi population lifestyle (adopting western model), lack of cancer awareness, lack of screening & early detection programs, social barriers toward cancer investigations. Obesity, genetics, sedentary lifestyle, tobacco use, viral infection, and iodine & Vit-D deficiency represent the apparent cancer risk factors in Saudi Arabia.


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    [1] WHO (2018) Cancer, Fact sheets 2018. Available from: https://www.who.int/news-room/fact-sheets/detail/cancer.
    [2] Ervik M, Lam F, Ferlay J, et al. (2016) Cancer Today. Lyon, France: International Agency for Research on Cancer. Available from: http://gco.iarc.fr/today.
    [3] WHO. Global status report on noncommunicable diseases 2010. Available from: https://www.who.int/nmh/publications/ncd_report_full_en.pdf.
    [4] Alharthi H (2018) Healthcare predictive analytics: An overview with a focus on Saudi Arabia. J Infect Public Health 11: 749–756. doi: 10.1016/j.jiph.2018.02.005
    [5] WHO, International Agency for Research in Cancer (IARC). Saudi Arabia. Source: Globocan 2018. Available from: https://gco.iarc.fr/today/data/factsheets/populations/682-saudi-arabia-fact-sheets.pdf.
    [6] Bassam AA, Rakan FA, Ahmed AA, et al. (2017) Breast cancer in Saudi Arabia and its possible risk factors. J Cancer Policy 12: 83–89. doi: 10.1016/j.jcpo.2017.03.004
    [7] Agide FD, Sadeghi R, Garmaroudi G, et al. (2018) A systematic review of health promotion interventions to increase breast cancer screening uptake: from the last 12 years. Eur J Public Health 28: 1149–1155. doi: 10.1093/eurpub/ckx231
    [8] Aldiab A, Al Khayal KA, Al Obaid OA, et al. (2017) Clinicopathological Features and Predictive Factors for Colorectal Cancer Outcome in the Kingdom of Saudi Arabia. Oncology 92: 75–86. doi: 10.1159/000450857
    [9] Alsanea N, Almadi MA, Abduljabbar AS, et al. (2015) National Guidelines for Colorectal Cancer Screening in Saudi Arabia with strength of recommendations and quality of evidence. Ann Saudi Med 35: 189–195. doi: 10.5144/0256-4947.2015.189
    [10] Zubaidi AM, AlSubaie NM, AlHumaid AA, et al. (2015) Public awareness of colorectal cancer in Saudi Arabia: A survey of 1070 participants in Riyadh. Saudi J Gastroenterol 21: 78–83. doi: 10.4103/1319-3767.153819
    [11] Alqahtani M, Edwards C, Buzzacott N, et al. (2018) Screening for Lynch syndrome in young Saudi colorectal cancer patients using microsatellite instability testing and next generation sequencing. Fam Cancer 17: 197–203. doi: 10.1007/s10689-017-0015-9
    [12] Siegel RL, Miller KD, Jemal A (2018) Cancer statistics, 2018. CA Cancer J Clin 68: 7–30. doi: 10.3322/caac.21442
    [13] Taha MS, Almsned FM, Hassen MA, et al. (2018) Demographic and histopathological patterns of neuro-epithelial brain tumors in Eastern Province of Saudi Arabia. Neurosciences (Riyadh, Saudi Arabia) 23: 18–22. doi: 10.17712/nsj.2018.1.20160543
    [14] Aljuhani SH, Bamaroof SA, Alghamdi TH, et al. (2018) Public awareness of central nervous system tumors in the Kingdom of Saudi Arabia. Neurosciences (Riyadh, Saudi Arabia) 23: 227–237. doi: 10.17712/nsj.2018.3.20180055
    [15] Azim HA, Abdel-Malek R, Kassem L (2018) Predicting Brain Metastasis in Breast Cancer Patients: Stage Versus Biology. Clin Breast Cancer 18: e187–e195. doi: 10.1016/j.clbc.2017.08.004
    [16] Rauf MS, Akhtar S, Maghfoor I (2015) Changing trends of adult lymphoma in the Kingdom of Saudi Arabia - comparison of data sources. Asian Pac J Cancer Prev 16: 2069–2072. doi: 10.7314/APJCP.2015.16.5.2069
    [17] Ahmed MI, Ahmed MS, Nizamani WM, et al. (2018) Beyond PET/CT in lymphoma: Does PET/CT has similar diagnostic accuracy in recurrent lymphoma cases in TB-endemic countries. Pak J Radiol 28: 17–23.
    [18] Nagi AH, Minawy LA, Naseem N, et al. (2010) A study of the morphological patterns of extranodal non-Hodgkin lymphoma in Pakistani and Saudi populations. Biomedica 26: 118–123.
    [19] Al Diab AR, Aleem A, Qayum A, et al. (2011) Clinico-pathological pattern of extranodal non-Hodgkin's lymphoma in Saudi Arabia. Asian Pac J Cancer Prev 12: 3277–3282.
    [20] Saudi Cancer Registry Annual Report (2014) Riyadh: Ministry of Health. Available from: https://nhic.gov.sa/eServices/Documents/2014.pdf.
    [21] Shamoon RP, Ali MD, Shabila NP (2018) Overview and outcome of Hodgkin's Lymphoma: Experience of a single developing country's oncology centre. Plos One 13.
    [22] Toorani ZA, Sridhar S, Roque W (2018) A rare concurrence of Hofgkin's lymphoma, Sickle cell disease and Diabetes mellitus. Bahrain Med Bull 40: 118–120. doi: 10.12816/0047565
    [23] Medina-Rico M, Ramos HL, Lobo M, et al. (2018 Epidemiology of renal cancer in developing countries: Review of the literature. Can Urol Assoc 12: 154–162.
    [24] Alkhateeb SS, Alothman AS, Addar AM, et al. (2018) Kidney cancer in Saudi Arabia. Saudi Med J 39: 459–563. doi: 10.15537/smj.2018.5.22641
    [25] Mahasin SZ, Aloudah N, Al-Surimi K, et al. (2018) Epidemiology profile of renal cell carcinoma: A 10-years patients' experience at king Abdulaziz Medical City, National Huard Health Affairs, Saudi Arabia. Urol Ann 10: 59–64. doi: 10.4103/UA.UA_102_17
    [26] Bafaraj S, Awad I, Jastaniah S, et al. (2018) Screening for thyroid diseases among students of applied medical sciences at King Abdulaziz University, Saudi Arabia. Saudi Med J 39: 311–314. doi: 10.15537/smj.2018.3.22137
    [27] Saeed MI, Hassan AA, Butt ME, et al. (2018) Pattern of thyroid lesions in western region of Saudi Arabia: A retrospective analysis and literature review. J Clin Med Res 10: 106–116. doi: 10.14740/jocmr3202w
    [28] PRISMA (2018) Statement on transparent reporting of systematic reviews and meta-analysis. Available from: http://www.prisma-statement.org/.
    [29] GLOBECAN 2012. International Agency for Research on Cancer [online database]. Available from: http://www-dep.iarc.fr/.
    [30] WHO. Breast cancer burden 2017. Available from: http://www.who.int/cancer/detection/breastcancer/en/index1.html.
    [31] Mir R, Javid J, Al Balawi A, et al. (2018) A germline mutation in BRCA1 3'UTR variant predicts susceptibility to breast cancer in a Saudi Arabian population. Asian Pac J Cancer Prev 19: 859–866.
    [32] Al Balawi IA, Mir R, Abu-Duhier FM (2018) Potential impact of vascular endothelial growth factor gene variation ( − 2578C> A) on breast cancer susceptibility in Saudi Arabia: a case-control study. Asian Pac J Cancer Prev 19: 1135–1143.
    [33] Alhuquail AJ, Alzahrani A, Almubarak H, et al. (2018) High prevalence of deliterous BRCA 1 and BRCA 2 germline mutations in arab breast and ovarian cancer patients. Breast Cancer Res Treat.
    [34] Rahman S, Zayed H (2018) Breast cancer in the GCC countries: A focus on BRCA1/2 and non-BRAC1/2 genes. Gene.
    [35] Abulkhair O, Saadeddin A, Makran O, et al. (2015) Vitamin D levels and breast cancer characteristics: Findings in patients from Saudi Arabia. J Steroid Biochem Mol Biol.
    [36] Ifediora CO (2019) Re-thinking breast and cervical cancer preventive campaigns in developing countries: the case for interventions at high schools. BMC Public Health 19: 503. doi: 10.1186/s12889-019-6890-2
    [37] Alshatwi AA, Hasan TN, Shafi G, et al. (2011) A single nucleotide polymorphism in the TP53 and MDM-2 gene modifies breast cancer risk in an ethnic Arab population. Fundam Clin Pharmacol 26: 438–443. doi: 10.1111/j.1472-8206.2011.00939.x
    [38] Al-Qasem A, Toulimat M, Tulbah A, et al. (2012) The p53 codon 72 polymorphism is associated with risk and early onset of breast cancer among Saudi women. Oncol Lett 3: 875–878.
    [39] Alshatwi AA, Shafi G, Hasan TN, et al. (2012) Differential Expression Profile and Genetic Variants of MicroRNAs Sequences in Breast Cancer Patients. Plos One 7: e30049. doi: 10.1371/journal.pone.0030049
    [40] Alghamdi IG, Hussain II, Alghamdi MS, et al. (2013) The incidence rate of female breast cancer in Saudi Arabia: an observational descriptive epidemiological analysis of data from Saudi Cancer Registry 2001–2008. Breast Cancer: Targets Ther 5: 103–109. doi: 10.2147/BCTT.S50750
    [41] Alanazi M, Pathan AAK, Arifeen Z, et al. (2013) Association between PARP-1 V762A polymorphism and breast cancer susceptibility in Saudi population. Plos One 8: e85541. doi: 10.1371/journal.pone.0085541
    [42] Yousef FM, Jacobs ET, Kang PT, et al. (2013) Vitamin D status and breast cancer in Saudi Arabian women: case-control study. Am J Clin Nutr 98: 105–110. doi: 10.3945/ajcn.112.054445
    [43] Al-Mutairi FM, Alanazi M, Shalaby M, et al. (2013) Association of XRCC1 gene polymorphisms with breast cancer susceptibility in Saudi patients. Asian Pac J Cancer Prev 14: 3809–3813. doi: 10.7314/APJCP.2013.14.6.3809
    [44] Alokail MS, Al-Daghri N, Abdulkareem A, et al. (2013) Metabolic syndrome biomarkers and early breast cancer in Saudi women: evidence for the presence of a systemic stress response and/ or a pre existing metabolic syndrome-related neoplasia risk? BMC Cancer 13: 54. doi: 10.1186/1471-2407-13-54
    [45] Hasan TN, Shafi G, Syed NA, et al. (2013) Lack of association of BRCA1 and BRCA2 variants with breast cancer in an ethnic population of Saudi Arabia, an emerging high-risk area. Asian Pac J Cancer Prev 14: 5671–5674. doi: 10.7314/APJCP.2013.14.10.5671
    [46] Elkum N, Al-Tweigeri T, Ajarim D, et al. (2014) Obesity is a significant risk factor for breast cancer. BMC Cancer 14: 788. doi: 10.1186/1471-2407-14-788
    [47] Benard F, Barkun AN, Martel M, et al. (2018) Systematic review of colorectal cancer screening guidelines for average-risk adults: Summarising the current global recommendations. World J Gasteroenterol 24: 124–138. doi: 10.3748/wjg.v24.i1.124
    [48] Williams CE, Williams EA, Corfe BM (2018) Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: what do we know and what do we need to know? Eur J Clin Nutr 72: 1358–1363. doi: 10.1038/s41430-017-0064-z
    [49] Al-Harithy RN, Al-Ghafari AB (2010) Risistin in human colon cancer. Saudi Med J 31: 495–500.
    [50] Al-Harithy RN, Al-Zahrani MH (2012) The adinponectin gene, ADIPOQ, and genetic susceptibility to colon cancer. Oncol Lett 3: 176–180. doi: 10.3892/ol.2011.443
    [51] Al-Harithy RN, Al-Ghazzawi (2011) Polymorphisms of the deoxyribonucleic acid (DNA) repair gene XRCC1 and risk of colon cancer in Saudi Arabia. Int J Med Med Sci 3: 281–288.
    [52] Alharithy RN (2014) Polymorphisms in RETN gene and susceptibility to colon cancer in Saudi patients. Ann Saudi Med 34: 334–339. doi: 10.5144/0256-4947.2014.334
    [53] Alghafari AB, Balamash KS, Doghaither HA, et al. (2019) "Relationship between Serum Vitamin D and Calcium Levels and Vitamin D Receptor Gene Polymorphisms in Colorectal Cancer". BioMed Res Int.
    [54] Albasri A, El-Siddig A, Hussainy A, et al. (2014a) Histopathologic characterization of prostrate diseases in Madinah, Saudi Arabia. Asian Pac J Cancer Prev 15: 4175–4179.
    [55] Ross-Adams H, Lamb AD, Dunning MJ, et al. (2015) Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study. EBioMedicine 2: 1133–1144. doi: 10.1016/j.ebiom.2015.07.017
    [56] Travis RC, Appleby PN, Martin RM, et al. (2016) A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk. Cancer Res 76: 2288–2300. doi: 10.1158/0008-5472.CAN-15-1551
    [57] Al-Abdin OZ, Rabah DM, Badr G, et al. (2013) Differences in prostrate cancer detection between Canadian and Saudi populations. Braz J Med Biol Res 46: 539–545. doi: 10.1590/1414-431X20132757
    [58] Alghamdi IG, Hussain II, Alghamdi MS, et al. (2014) The incidence rate of prostate cancer in Saudi Arabia: an observational descriptive epidemiological analysis of data from Saudi Cancer registry 2001–2008. Hematol/Oncol Stem Cell Ther 7: 18–26. doi: 10.1016/j.hemonc.2013.10.001
    [59] Shafi RG, Al-Mansour MM, Kanfar SS, et al. (2017) Hodgkin Lymphoma Outcome: A Retrospective Study from 3 Tertiary Centers in Saudi Arabia. Oncol Res Treat 40: 288–292. doi: 10.1159/000460819
    [60] Dalia S, Chavez J, Castillo JJ, et al. (2013) Hepatitis B infection increases the risk of non-Hodkin lymphoma: A meta-analysis of observational studies. Leuk Res 37: 1107–1115. doi: 10.1016/j.leukres.2013.06.007
    [61] Alkhateeb SS, Alkhateeb JM, Ahrashidi EA (2015) Increasing trends in kidney cancer over the last 2 decades in Saudi Arabia. Saudi Med J 36: 698–703. doi: 10.15537/smj.2015.6.10841
    [62] Hajeer MH, Awad HA, Abdullah NI, et al. (2018) The rising trend in papillary thyroid carcinoma. Saudi Med J 39: 147–153. doi: 10.15537/smj.2018.2.21211
    [63] Zhang Y, Chen Y, Huang H, et al. (2015) Diagnostic radiography exposure increases the risk for thyroid microcarcinoma: a population-based case-control study. Eur J Cancer Prev 24: 439–446. doi: 10.1097/CEJ.0000000000000169
    [64] Hussain F, Iqbal S, Mehmood A, et al. (2013) Incidence of thyroid cancer in kingdom of Saudi Arabia, 2000–2010. Hematol/Oncol Stem Cell Ther 6: 58–64. doi: 10.1016/j.hemonc.2013.05.004
    [65] Albasri A, Sawaf Z, Hussainy AS, et al. (2014c) Histopathological patterns of thyroid disease in Al-Madinah region of Saudi Arabia. Asian Pac J Cancer Prev 15: 5565–5570.
    [66] Abdo N, Khader YS, Abdelrahman M, et al. (2016) Respiratory health outcomes and air pollution in the Eastern Mediterranean Region: a systematic review. Rev Environ Health 31: 259–280. doi: 10.1515/reveh-2015-0076
    [67] Al-Hazzaa HM (2018) Physical inactivity in Saudi Arabia revisited: A systematic review of inactivity prevalence and perceived barriers to active living. Int J Health Sci (Qassim) 12: 50–64.
    [68] Al-Musa HM, Awadalla NJ, Mahfouz AA (2019) Male Partners' Knowledge, Attitudes, and Perception of Women's Breast Cancer in Abha, Southwestern Saudi Arabia. Int J Environ Res Public Health 16: 3089. doi: 10.3390/ijerph16173089
    [69] Aldohaian AI, Alshammari SA, Arafah DM (2019) Using the health belief model to assess beliefs and behaviors regarding cervical cancer screening among Saudi women: a cross-sectional observational study. BMC Womens Health 19: 6. doi: 10.1186/s12905-018-0701-2
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