Recent developments and future perspectives in aging and macrophage immunometabolism

Brandt D. Pence; Brandt D. Pence

doi:10.3934/molsci.2021015

AIMS Molecular Science

2021, Volume 8, Issue 3: 193-201. doi: 10.3934/molsci.2021015

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Review

Recent developments and future perspectives in aging and macrophage immunometabolism

Brandt D. Pence ^{1,2
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1.
College of Health Sciences, University of Memphis, Memphis, TN, USA
2.
Center for Nutraceutical and Dietary Supplement Research, University of Memphis, Memphis, TN, USA

Received: 14 July 2021 Accepted: 24 August 2021 Published: 26 August 2021

Aging is the strongest contributor to the development and severity of many chronic and infectious diseases, primarily through age-related increases in low-grade inflammation (inflammaging) and decreases in immune function (immunosenescence). Metabolic reprogramming in immune cells is a significant contributor to functional and phenotypic changes in these cells, but little is known about the direct effect of aging on immunometabolism. This review highlights several recent advances in this field, focusing on mitochondrial dysfunction, NAD+ metabolism, and therapeutic reprogramming in aged monocytes and macrophages. Perspectives on opportunities for future research in this area are also provided. Targeting immunometabolism is a promising strategy for designing therapeutics for a wide variety of age-related diseases.
- aging,
- immunometabolism,
- macrophage,
- monocyte,
- mitochondrial function,
- NAD+
Citation: Brandt D. Pence. Recent developments and future perspectives in aging and macrophage immunometabolism[J]. AIMS Molecular Science, 2021, 8(3): 193-201. doi: 10.3934/molsci.2021015

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Abstract

Aging is the strongest contributor to the development and severity of many chronic and infectious diseases, primarily through age-related increases in low-grade inflammation (inflammaging) and decreases in immune function (immunosenescence). Metabolic reprogramming in immune cells is a significant contributor to functional and phenotypic changes in these cells, but little is known about the direct effect of aging on immunometabolism. This review highlights several recent advances in this field, focusing on mitochondrial dysfunction, NAD+ metabolism, and therapeutic reprogramming in aged monocytes and macrophages. Perspectives on opportunities for future research in this area are also provided. Targeting immunometabolism is a promising strategy for designing therapeutics for a wide variety of age-related diseases.

Acknowledgments

BDP is funded by American Heart Association award 19TPA34910232 and a Collaborative Research Network (CORNET) award from the University of Memphis and the University of Tennessee Health Science Center.

Conflict of interest

The author declares no conflict of interest in this paper.

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