Studies on bioactivities of Manuka and regional varieties of honey for their potential use as natural antibiotic agents for infection control related to wound healing and in pharmaceutical formulations

Divakar Dahiya; Caoimhin Mackin; Poonam Singh Nigam; Divakar Dahiya; Caoimhin Mackin; Poonam Singh Nigam

doi:10.3934/microbiol.2024015

AIMS Microbiology

2024, Volume 10, Issue 2: 288-310. doi: 10.3934/microbiol.2024015

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Review

Studies on bioactivities of Manuka and regional varieties of honey for their potential use as natural antibiotic agents for infection control related to wound healing and in pharmaceutical formulations

1a.
Wexham Park Hospital, Wexham Street, Slough SL2 4HL, England, UK
1b.
current address: Haematology and Blood Transfusion, Basingstoke and North Hampshire Hospital, Basingstoke RG24 9NA, UK
2.
Biomedical Sciences Research Institute, Ulster University, Coleraine BT52 1SA, UK

Received: 02 January 2024 Revised: 10 April 2024 Accepted: 23 April 2024 Published: 06 May 2024

Presently, most of the reported infections are of a bacterial origin; however, this leads to a limit within the literature and research around infections caused by fungal pathogens, which are now developing resistance to antibiotic medicines. Of the natural antimicrobial agents, honey has been observed with demonstrable and highly exploitable antimicrobial and infection control related to wound healing properties; therefore, it has been incorporated into many standard pharmaceutical formulations. Generally, these products utilize a pure sample of honey as a bioactive ingredient in a product which has been purposely designed for the convenience of application. This article aims to review information available from published reports on various bioactivities of a variety of medical-grade honey products, including manuka and other conventional non-manuka types sourced from different floral types and geographical regions. Additionally, this review highlights the antibiotic activities of various types of honey products tested against pathogenic strains of bacteria, yeast and fungi, and their applications in the formulation of healthcare products.
- infection,
- honey,
- Manuka,
- bioactivity,
- antibiotic,
- antibacterial,
- antifungal,
- wound healing,
- pharmaceutical
Citation: Divakar Dahiya, Caoimhin Mackin, Poonam Singh Nigam. Studies on bioactivities of Manuka and regional varieties of honey for their potential use as natural antibiotic agents for infection control related to wound healing and in pharmaceutical formulations[J]. AIMS Microbiology, 2024, 10(2): 288-310. doi: 10.3934/microbiol.2024015

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Abstract

Presently, most of the reported infections are of a bacterial origin; however, this leads to a limit within the literature and research around infections caused by fungal pathogens, which are now developing resistance to antibiotic medicines. Of the natural antimicrobial agents, honey has been observed with demonstrable and highly exploitable antimicrobial and infection control related to wound healing properties; therefore, it has been incorporated into many standard pharmaceutical formulations. Generally, these products utilize a pure sample of honey as a bioactive ingredient in a product which has been purposely designed for the convenience of application. This article aims to review information available from published reports on various bioactivities of a variety of medical-grade honey products, including manuka and other conventional non-manuka types sourced from different floral types and geographical regions. Additionally, this review highlights the antibiotic activities of various types of honey products tested against pathogenic strains of bacteria, yeast and fungi, and their applications in the formulation of healthcare products.

Author contributions

D.D., C.M., P.S.N. literature search, writing—review and editing, and revision. All authors have read and agreed to the published version of the manuscript.

Funding

The writing of this review did not receive any grants from funding agencies in the public, commercial, or not-for-profit sectors.

Institutional review board statement

Not applicable.

Informed consent statement

Not applicable.

Data availability statement

Not applicable.

Conflicts of interest

The authors declare no conflicts of interest.

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