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Monoamine neurotransmitters and mood swings: a dynamical systems approach


  • Received: 23 November 2021 Revised: 17 January 2022 Accepted: 09 February 2022 Published: 15 February 2022
  • Serotonin, dopamine and norepinephrine are monoamine neurotransmitters that modulate our mood state. Hence, imbalances in the levels of these neurotransmitters have been linked to the incidence of several psychiatric disorders. Here, a mathematical model written in terms of ordinary differential equations is proposed to represent the interaction of these three neurotransmitters. It is analytically and numerically shown that this model can experience a Hopf bifurcation. Thus, by varying a parameter value, the neurotransmitter levels can change from a steady state to an oscillatory behavior, which may be at least a partial explanation of the mood swings observed in depressed people.

    Citation: R. Loula, L. H. A. Monteiro. Monoamine neurotransmitters and mood swings: a dynamical systems approach[J]. Mathematical Biosciences and Engineering, 2022, 19(4): 4075-4083. doi: 10.3934/mbe.2022187

    Related Papers:

  • Serotonin, dopamine and norepinephrine are monoamine neurotransmitters that modulate our mood state. Hence, imbalances in the levels of these neurotransmitters have been linked to the incidence of several psychiatric disorders. Here, a mathematical model written in terms of ordinary differential equations is proposed to represent the interaction of these three neurotransmitters. It is analytically and numerically shown that this model can experience a Hopf bifurcation. Thus, by varying a parameter value, the neurotransmitter levels can change from a steady state to an oscillatory behavior, which may be at least a partial explanation of the mood swings observed in depressed people.



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