A systematic review on the development of radiosensitizers, with cancer selectivity, for radiotherapy using ionizing radiation

Hengmao Zhang; Haobo Zhao; Ming Chi; Kaizhen Yang; Yukang Chen; Jiahui Mao; Peilin Li; Zukang Wang; Faqiao Song; Wenxuan Guo; Miyu Sakai; Junko Takahashi; Hengmao Zhang; Haobo Zhao; Ming Chi; Kaizhen Yang; Yukang Chen; Jiahui Mao; Peilin Li; Zukang Wang; Faqiao Song; Wenxuan Guo; Miyu Sakai; Junko Takahashi

doi:10.3934/bioeng.2023008

AIMS Bioengineering

2023, Volume 10, Issue 2: 89-110. doi: 10.3934/bioeng.2023008

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Review

A systematic review on the development of radiosensitizers, with cancer selectivity, for radiotherapy using ionizing radiation

Graduate School of Information, Production and Systems, Waseda University, Fukuoka, Japan
These authors equally contributed.

Received: 12 December 2022 Revised: 02 March 2023 Accepted: 13 March 2023 Published: 24 March 2023

Background
At present, radiotherapy (RT) is widely used in cancer treatment, but traditional RT methods using ionizing radiation cannot avoid damage to normal tissues. Therefore, the development of a more precise RT is an important research direction for relevant researchers. Concurrently, research on radiosensitizers (RSs) using nanotechnology is developing rapidly, and RSs that are selective for cancerous tissues or cancer cells may become an important part of future precision RT.
Methods
Using RSs and RT as keywords, the relevant papers in the PubMed database from 2013 to 2022 were summarized. Articles on RS with selectivity to cancer tissue were collected. Among the selected articles, RSs were classified into “active selectivity”, “passive selectivity” and “others” according to the different selectivity principles of RSs.
Results
A total of 771 articles were retrieved from PubMed. After screening, the research content of the remaining 79 articles was found to be related to the selectivity of RSs to cancer tissues. Among them, 28 articles were classified as “active selectivity”, and most of the sensitizers in this category could target specific targets in cancer tissues. There were 30 papers classified as “passive selectivity” and the selectivity principles were mainly the enhanced permeability and retention (EPR) effect, aggregation caused by pH sensitivity, and aggregation in anoxic environments. There were 21 papers classified as “others”. The sensitizers in these studies showed selectivity for cancer tissue, but the mechanism was not clear. This review attempts to summarize studies on RSs that are selective for cancer tissues.
Conclusions
We reviewed nearly ten years of literature on selective RSs and classified the selectivity of different RSs into active and passive selectivities.
- radiotherapy,
- ionizing radiation,
- radiosensitizer,
- precise treatment,
- cancer selectivity,
- nanotechnology,
- nanoparticle
Citation: Hengmao Zhang, Haobo Zhao, Ming Chi, Kaizhen Yang, Yukang Chen, Jiahui Mao, Peilin Li, Zukang Wang, Faqiao Song, Wenxuan Guo, Miyu Sakai, Junko Takahashi. A systematic review on the development of radiosensitizers, with cancer selectivity, for radiotherapy using ionizing radiation[J]. AIMS Bioengineering, 2023, 10(2): 89-110. doi: 10.3934/bioeng.2023008

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Abstract

Background

At present, radiotherapy (RT) is widely used in cancer treatment, but traditional RT methods using ionizing radiation cannot avoid damage to normal tissues. Therefore, the development of a more precise RT is an important research direction for relevant researchers. Concurrently, research on radiosensitizers (RSs) using nanotechnology is developing rapidly, and RSs that are selective for cancerous tissues or cancer cells may become an important part of future precision RT.

Methods

Using RSs and RT as keywords, the relevant papers in the PubMed database from 2013 to 2022 were summarized. Articles on RS with selectivity to cancer tissue were collected. Among the selected articles, RSs were classified into “active selectivity”, “passive selectivity” and “others” according to the different selectivity principles of RSs.

Results

A total of 771 articles were retrieved from PubMed. After screening, the research content of the remaining 79 articles was found to be related to the selectivity of RSs to cancer tissues. Among them, 28 articles were classified as “active selectivity”, and most of the sensitizers in this category could target specific targets in cancer tissues. There were 30 papers classified as “passive selectivity” and the selectivity principles were mainly the enhanced permeability and retention (EPR) effect, aggregation caused by pH sensitivity, and aggregation in anoxic environments. There were 21 papers classified as “others”. The sensitizers in these studies showed selectivity for cancer tissue, but the mechanism was not clear. This review attempts to summarize studies on RSs that are selective for cancer tissues.

Conclusions

We reviewed nearly ten years of literature on selective RSs and classified the selectivity of different RSs into active and passive selectivities.

Acknowledgments

This work was supported by the Japanese Society for the Promotion of Science (JSPS) KAKENHI, Grant Numbers 18H02705, 20K08003, and 22H03964.

Conflict of interest

The author declares no conflicts of interest in this paper.

Author contributions

Hengmao Zhang, Haobo Zhao, and Junko Takahashi were responsible for the conception and design of this study. Hengmao Zhang, Haobo Zhao, Ming Chi, Kaizhen Yang, Yukang Chen, Jiahui Mao, Peilin Li, Zukang Wang, Faqiao Song, Wenxuan Guo, Miyu Sakai, and Junko Takahashi were responsible for the acquisition, analysis, and interpretation of data. All authors were responsible for drafting and revising the data, and final approval of the version to be published.

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