Manuscript Topics

Nitric oxide (NO) was first identified as the endothelial-derived relaxing factor (EDRF) just over 30 years ago followed rapidly by the characterization of various nitric oxide synthases (NOS). This hydrophobic, short-lived, produced-on-demand gaseous molecule has subsequently been shown to be involved in many important functions. These include the regulation of the cardiovascular, immune and nervous systems. Its significance is further underscored by the fact that in the human nervous system, nitric oxide has been implicated in such important topics as learning and memory and neurodegeneration. In this special issue we would like to focus on the effects of nitric oxide on all aspects of nervous system function. This could include, but is not limited to, direct effects of NO on membrane potential/currents, Ca²⁺-levels, modulatory/synchronizing effects on neuronal populations, imaging studies, signal transduction, gene expression, functions as a retrograde synaptic transmitter/modulator and effects on behavior. However all related subjects are encouraged to submit. This can include any vertebrate and invertebrate model systems either in vivo or in vitro.

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