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Mathematical Biosciences and Engineering

2013, Volume 10, Issue 3: 667-690. doi: 10.3934/mbe.2013.10.667
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On the sensitivity of feature ranked lists for large-scale biological data

  • 1.
    Silesian University of Technology, Institute of Automatic Control, Akademicka 16, 44-100 Gliwice
  • Received: 01 June 2012 Accepted: 29 June 2018 Published: 01 April 2013

  • MSC : 92-08.

  • The problem of feature selection for large-scale genomic data, for example from DNA microarray experiments, is one of the fundamental and well-investigated problems in modern computational biology.From the computational point of view, a selected gene list should be characterized by good predictive power and should be understood and well explained from the biological point of view.Recently, another feature of selected gene lists is increasingly investigated, namely their stability which measures how the content and/or the gene order change when the data are perturbed.In this paper we propose a new approach to analysis of gene list stability, termed the sensitivity index, that does not require any data perturbationand allows the gene list that is most reliable in a biological sense to be chosen.

    Citation: Danuta Gaweł, Krzysztof Fujarewicz. On the sensitivity of feature ranked lists for large-scale biological data[J]. Mathematical Biosciences and Engineering, 2013, 10(3): 667-690. doi: 10.3934/mbe.2013.10.667

    Related Papers:

  • The problem of feature selection for large-scale genomic data, for example from DNA microarray experiments, is one of the fundamental and well-investigated problems in modern computational biology.From the computational point of view, a selected gene list should be characterized by good predictive power and should be understood and well explained from the biological point of view.Recently, another feature of selected gene lists is increasingly investigated, namely their stability which measures how the content and/or the gene order change when the data are perturbed.In this paper we propose a new approach to analysis of gene list stability, termed the sensitivity index, that does not require any data perturbationand allows the gene list that is most reliable in a biological sense to be chosen.


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  • © 2013 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
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