Neuro-dermatological association between psoriasis and depression: an immune-mediated inflammatory process validating skin-brain axis theory

Shahzaib Maqbool; Arham Ihtesham; Muhammad Nadeem Langove; Sara Jamal; Tabdar Jamal; Hafiz Abu Safian; Shahzaib Maqbool; Arham Ihtesham; Muhammad Nadeem Langove; Sara Jamal; Tabdar Jamal; Hafiz Abu Safian

doi:10.3934/Neuroscience.2021018

AIMS Neuroscience

2021, Volume 8, Issue 3: 340-354. doi: 10.3934/Neuroscience.2021018

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Neuro-dermatological association between psoriasis and depression: an immune-mediated inflammatory process validating skin-brain axis theory

1.
Department of Medicine, Rawalpindi Medical University, Pakistan
2.
Department of Haematology, Resident Haematology atomic energy Islamabad, Pakistan
3.
Department of Radiology, Resident Radiology Kahuta Research Laboratory (KRL) hospital, Pakistan

Received: 26 January 2021 Accepted: 08 March 2021 Published: 10 March 2021

Objective
Our study's motive was to recognize various immune-mediated inflammatory processes involved in the pathogenesis of depression and psoriasis and interlink between them based on inflammatory mediators.

Methods
A careful and comprehensive literature search was done through various databases like PubMed, Google Scholar, and EBSCO. A total of 56 studies were included in our study after careful screening.

Results
The immune-mediated inflammatory process was significantly associated with the pathogenesis of both depression and psoriasis. Most of the inflammatory markers involved in Psoriasis (TNF-α, IL-2, IL-6, IL-23, IL-1β, IL-10), and increased serotonin transporters (5-HTT) were also found in the pathogenesis of depression, showing the immune-inflammatory linkage between psoriasis and major depression. Based on immune chemistry, the levels of CD2⁺, CD4⁺, CD8⁺ T-lymphocytes were also found to be raised in both depression and psoriasis, validating their relationship. Hyperactivity of HPA-axis was also found another interlink between them along with reduced melatonin amount.

Conclusions
According to various studies, the neuro-dermatological association between psoriasis and depression is significant. Different immune markers involved in the pathogenesis of depression and psoriasis also show the bidirectional association between them. However, this association between psoriasis and depression is positively correlated, but more work is required to answer why all depressed patients fail to develop psoriasis and why all psoriatic patients fail to develop depression.
- depression,
- neuro-dermatology,
- psoriasis,
- skin-brain axis
Citation: Shahzaib Maqbool, Arham Ihtesham, Muhammad Nadeem Langove, Sara Jamal, Tabdar Jamal, Hafiz Abu Safian. Neuro-dermatological association between psoriasis and depression: an immune-mediated inflammatory process validating skin-brain axis theory[J]. AIMS Neuroscience, 2021, 8(3): 340-354. doi: 10.3934/Neuroscience.2021018

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Abstract

Objective

Our study's motive was to recognize various immune-mediated inflammatory processes involved in the pathogenesis of depression and psoriasis and interlink between them based on inflammatory mediators.

Methods

A careful and comprehensive literature search was done through various databases like PubMed, Google Scholar, and EBSCO. A total of 56 studies were included in our study after careful screening.

Results

The immune-mediated inflammatory process was significantly associated with the pathogenesis of both depression and psoriasis. Most of the inflammatory markers involved in Psoriasis (TNF-α, IL-2, IL-6, IL-23, IL-1β, IL-10), and increased serotonin transporters (5-HTT) were also found in the pathogenesis of depression, showing the immune-inflammatory linkage between psoriasis and major depression. Based on immune chemistry, the levels of CD2⁺, CD4⁺, CD8⁺ T-lymphocytes were also found to be raised in both depression and psoriasis, validating their relationship. Hyperactivity of HPA-axis was also found another interlink between them along with reduced melatonin amount.

Conclusions

According to various studies, the neuro-dermatological association between psoriasis and depression is significant. Different immune markers involved in the pathogenesis of depression and psoriasis also show the bidirectional association between them. However, this association between psoriasis and depression is positively correlated, but more work is required to answer why all depressed patients fail to develop psoriasis and why all psoriatic patients fail to develop depression.

Ethical statement

Ethical values were considered with full capacity by each author.

Competing interest

The authors declare no conflict of interest.

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