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AIMS Medical Science

2020, Volume 7, Issue 2: 57-68. doi: 10.3934/medsci.2020005
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Research article

Oral tranexamic acid for bleeding during spinal surgery: A randomized double-blind placebo clinical trial

Running title: Oral tranexamic acid for spinal surgery
  • 1.
    Associate Professor of Neurosurgery; Department of Neurosurgery, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  • 2.
    Neurosurgery residency student; Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  • 3.
    Assistant professor of Neurosurgery, Department of Neurosurgery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  • 4.
    Assistant professor of Neurosurgery; Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  • 5.
    Fellowship of Neuroanesthesia; Assistant professor of Anesthrisiology; Department of Anesthesiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  • Received: 22 January 2020 Accepted: 18 May 2020 Published: 11 June 2020

  • Citation: Saleh Rasras, Nour Mohammad Mamizadeh, Hossein Safari, Arash Kiani, Zahra Rahimi. Oral tranexamic acid for bleeding during spinal surgery: A randomized double-blind placebo clinical trial[J]. AIMS Medical Science, 2020, 7(2): 57-68. doi: 10.3934/medsci.2020005

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    Acknowledgments


    This article is extracted from a thesis from Dr. Nour Mohammad Mamizadeh's residency thesis for a Ph.D. in Neurosurgery with the project no. U_96182 and Ethics Committee code (IR.AJUMS.REC.1396.1125) of Ahvaz Jundishapur University of Medical Sciences.
    A grant for this research project was given by the Ahvaz Jundishapur University of Medical Sciences. The authors would like to thank Dr. Pooyan Alizadeh, Dr. Hossein Jafari Marandi, and the Clinical Research Development Unit, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences for their support and assistance with this project. This work was approved by the Ahvaz Jundishapur University of Medical Sciences' Ethics Committee.

    Conflict of interest


    The authors declare no conflict of interest.

    [1] Smorgick Y, Baker KC, Bachison CC, et al. (2013) Hidden blood loss during posterior spine fusion surgery. Spine J 13: 877-881.
    [2] Irita K (2011) Risk and crisis management in intraoperative hemorrhage: Human factors in hemorrhagic critical events. Korean J Anesthesiol 60: 151-160.
    [3] Irita K (2014) Present status of critical hemorrhage and its management in the operating room. [Article in Japanese] Rinsho Byori 62: 1275-1279.
    [4] Yang L, Vuylsteke A, Gerrard C, et al. (2013) Postoperative fibrinogen level is associated with postoperative bleeding following cardiothoracic surgery and the effect of fibrinogen replacement therapy remains uncertain. J Thromb Haemost 11: 1519-1526.
    [5] McQuilten ZK, Crighton G, Engelbrecht S, et al. (2015) Transfusion interventions in critical bleeding requiring massive transfusion: A systematic review. Transfus Med Rev 29: 127-137.
    [6] Yuan L, Bao NR, Zhao JN (2015) Progress on hidden blood loss after hip replacement. [Article in Chinese] Zhongguo gu shang = China J Orthop Traumatol 28: 378-382.
    [7] Iorio J, Bennett J, Orlando G, et al. (2013) Does Amicar affect blood loss in patients with adolescent idiopathic scoliosis treated with pedicle screws and Ponte osteotomies?. Surg Technol Int 23: 291-295.
    [8] Dhawale AA, Shah SA, Sponseller PD, et al. (2012) Are antifibrinolytics helpful in decreasing blood loss and transfusions during spinal fusion surgery in children with cerebral palsy scoliosis?. Spine 37: E549-555.
    [9] Samdani A, Torre-Healy A, Asghar J, et al. (2008) Strategies to reduce blood loss during posterior spinal fusion for neuromuscular scoliosis: A review of current techniques and experience with a unique bipolar electrocautery device. Surg Technol Int 17: 243-248.
    [10] Thompson GH, Florentino-Pineda I, Armstrong DG, et al. (2007) Fibrinogen levels following Amicar in surgery for idiopathic scoliosis. Spine 32: 368-372.
    [11] Winter SF, Santaguida C, Wong J, et al. (2016) Systemic and topical use of tranexamic acid in spinal surgery: A systematic review. Global Spine J 6: 284-295.
    [12] Marik PE, Corwin HL (2008) Efficacy of red blood cell transfusion in the critically ill: A systematic review of the literature. Crit Care Med 36: 2667-2674.
    [13] Ngo K, Khemani R, Choi P, et al. (2013) Tranexamic acid reduces PRBC transfusion after posterior spine surgery for idiopathic scoliosis from the operating room to post-operative day four. J Anesthe Clin Res 4: 7.
    [14] Brown JR, Birkmeyer N, O'Connor GT (2007) Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery. Circulation 115: 2801-2813.
    [15] Alshryda S, Sarda P, Sukeik M, et al. (2011) Tranexamic acid in total knee replacement: A systematic review and meta-analysis. J Bone Joint Surgery British 93: 1577-1585.
    [16] Hardy JF, Desroches J (1992) Natural and synthetic antifibrinolytics in cardiac surgery. Can J Anaesth 39: 353-365.
    [17] Neilipovitz DT, Murto K, Hall L, et al. (2001) A randomized trial of tranexamic acid to reduce blood transfusion for scoliosis surgery. Anesth Analg 93: 82-87.
    [18] Elwatidy S, Jamjoom Z, Elgamal E, et al. (2008) Efficacy and safety of prophylactic large dose of tranexamic acid in spine surgery: A prospective, randomized, double-blind, placebo-controlled study. Spine 33: 2577-2580.
    [19] Yang B, Li H, Wang D, et al. (2013) Systematic review and meta-analysis of perioperative intravenous tranexamic acid use in spinal surgery. PloS One 8: e55436.
    [20] Neilipovitz DT (2004) Tranexamic acid for major spinal surgery. Eur Spine J 13: S62-65.
    [21] Horrow JC, Van Riper DF, Strong MD, et al. (1996) The Dose-Response relationship of tranexamic acid. Survey Anesthesiol 40: 9.
    [22] Shapiro F, Zurakowski D, Sethna NF (2007) Tranexamic acid diminishes intraoperative blood loss and transfusion in spinal fusions for duchenne muscular dystrophy scoliosis. Spine 32: 2278-2283.
    [23] Newton PO, Bastrom TP, Emans JB, et al. (2012) Antifibrinolytic agents reduce blood loss during pediatric vertebral column resection procedures. Spine 37: E1459-1463.
    [24] Yagi M, Machida M (2012) Does the intraoperative tranexamic acid decrease operative blood loss during posterior spinal fusion for treatment of adolescent idiopathic scoliosis?. Spine J 12: S99.
    [25] Wong J, El Beheiry H, Rampersaud YR, et al. (2008) Tranexamic acid reduces perioperative blood loss in adult patients having spinal fusion surgery. Anesth Analg 107: 1479-1486.
    [26] Gill JB, Chin Y, Levin A, et al. (2008) The use of antifibrinolytic agents in spine surgery: A meta-analysis. J Bone Joint Surg Am 90: 2399-2407.
    [27] Yuan C, Zhang H, He S (2013) Efficacy and safety of using antifibrinolytic agents in spine surgery: A meta-analysis. PLoS One 8: e82063.
    [28] Yang B, Li H, Wang D, et al. (2013) Systematic review and meta-analysis of perioperative intravenous tranexamic acid use in spinal surgery. PloS one 8: e55436.
    [29] Andersson L, Nilsson IM, Niléhn JE, et al. (1965) Experimental and clinical studies on AMCA, the antifibrinolytically active isomer of P-aminomethyl cyclohexane carboxylic acid. Scand J Haematol 2: 230-247.
    [30] Myles PS, Smith JA, Forbes A, et al. (2017) Tranexamic acid in patients undergoing coronary-artery surgery. N Engl J Med 376: 136-148.
    [31] Cheriyan T, Maier SP, Bianco K, et al. (2015) Efficacy of tranexamic acid on surgical bleeding in spine surgery: A meta-analysis. Spine J 15: 752-761.
    [32] Cordoba R, Tapia B, Aramburu O, et al. (2014) Tranexamic acid reduces blood transfusion, postoperative blood loss and length of hospital stay in total knee arthroplasty. J Blood Disorders Transf 5: 207.
    [33] Nuhi S, Tabrizi AG, Zarkhah L, et al. (2015) Impact of intravenous tranexamic acid on hemorrhage during endoscopic sinus surgery. Iran J Otorhinolaryngol 27: 349-354.
    [34] Aghadavoudi O, Bonakdar HM, Hashempour H (2017) The effect of intravenous tranexamic acid on perioperative bleeding and surgeon's satisfaction during mastoidectomy. J Isfahan Med School 34: 1653-1659.
    [35] Sarzaeem MM, Razi M, Kazemian G, et al. (2014) Comparing efficacy of three methods of tranexamic acid administration in reducing hemoglobin drop following total knee arthroplasty. J Arthroplasty 29: 1521-1524.
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  • © 2020 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
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  • 1. 

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