Search Advanced

AIMS Environmental Science

2015, Volume 2, Issue 2: 353-373. doi: 10.3934/environsci.2015.2.353
Previous Article Next Article
Review Special Issues

Traffic-related air pollution and brain development

  • Davis School of Gerontology and the Dornsife College, Department of Biological Sciences, University of Southern California, 3715 McClintock Ave, Los Angeles CA 9009-0191, USA
  • Received: 31 October 2014 Accepted: 23 April 2015 Published: 06 May 2015

  • Automotive traffic-related air pollution (TRP) imposes an increasing health burden with global urbanization. Gestational and early child exposure to urban TRP is associated with higher risk of autism spectrum disorders and schizophrenia, as well as low birth weight. While cardio-respiratory effects from exposure are well documented, cognitive effects are only recently becoming widely recognized. This review discusses effects of TRP on brain and cognition in human and animal studies. The mechanisms underlying these epidemiological associations are studied with rodent models of pre- and neonatal exposure to TRP, which show persisting inflammatory changes and altered adult behaviors and cognition. Some behavioral and inflammatory changes show male bias. Rodent models may identify dietary and other interventions for neuroprotection to TRP.

    Citation: Nicholas Woodward, Caleb E. Finch, Todd E. Morgan. Traffic-related air pollution and brain development[J]. AIMS Environmental Science, 2015, 2(2): 353-373. doi: 10.3934/environsci.2015.2.353

    Related Papers:

  • Automotive traffic-related air pollution (TRP) imposes an increasing health burden with global urbanization. Gestational and early child exposure to urban TRP is associated with higher risk of autism spectrum disorders and schizophrenia, as well as low birth weight. While cardio-respiratory effects from exposure are well documented, cognitive effects are only recently becoming widely recognized. This review discusses effects of TRP on brain and cognition in human and animal studies. The mechanisms underlying these epidemiological associations are studied with rodent models of pre- and neonatal exposure to TRP, which show persisting inflammatory changes and altered adult behaviors and cognition. Some behavioral and inflammatory changes show male bias. Rodent models may identify dietary and other interventions for neuroprotection to TRP.


    加载中
    [1] Brook RD, Rajagopalan S, Pope CA, et al. (2010) Particulate matter air pollution and cardiovascular disease an update to the scientific statement from the American Heart Association. Circulation 121: 2331-2378. doi: 10.1161/CIR.0b013e3181dbece1
    [2] Gong T, Almqvist C, Bölte S, et al. (2014) Exposure to Air Pollution From Traffic and Neurodevelopmental Disorders in Swedish Twins. Twin Res Hum Genet 17: 1-10. doi: 10.1017/thg.2013.90
    [3] Pope CA, Burnett RT, Thurston GD, et al. (2004) Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. Circulation 109: 71-77.
    [4] Stölzel M, Breitner S, Cyrys J, et al. (2007). Daily mortality and particulate matter in different size classes in Erfurt, Germany. J Expo Sci Environ Epidemiol 17: 458-467. doi: 10.1038/sj.jes.7500538
    [5] Pedersen CB, Raaschou-Nielsen O, Hertel O, et al. (2004) Air pollution from traffic and schizophrenia risk. Schizophr Res 66: 83-85. doi: 10.1016/S0920-9964(03)00062-8
    [6] Pietroiusti A, Campagnolo L, Fadeel B (2013) Interactions of engineered nanoparticles with organs protected by internal biological barriers. Small 9: 1557-1572. doi: 10.1002/smll.201201463
    [7] Wilhelm M, Ghosh JK, Su J, et al. (2012) Traffic-related air toxics and term low birth weight in Los Angeles County, California. Environ Health Perspect 120: 132-138.
    [8] Williams K, Alvarez X, Lackner AA (2001) Central nervous system perivascular cells are immunoregulatory cells that connect the CNS with the peripheral immune system. Glia 36:156-164. doi: 10.1002/glia.1105
    [9] Oberdörster G, Sharp Z, Atudorei V, et al. (2004) Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol 16: 437-445. doi: 10.1080/08958370490439597
    [10] Hoek G, Brunekreef B, Goldbohm S, et al. (2002). Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study. Lancet 360: 1203-1209. doi: 10.1016/S0140-6736(02)11280-3
    [11] Zhou Y, Levy JI (2007) Factors influencing the spatial extent of mobile source air pollution impacts: a meta-analysis. BMC Public Health 7: 89. doi: 10.1186/1471-2458-7-89
    [12] Environmental Protection Agency (2013) Federal Register. Rules and Regulations. Vol. 78, No10
    [13] Campbell A, Oldham M, Becaria A, et al. (2005) Particulate matter in polluted air may increase biomarkers of inflammation in mouse brain. Neurotox 26: 133-140. doi: 10.1016/j.neuro.2004.08.003
    [14] Utell MJ, Frampton MW (2000) Acute Health Effects of Ambient Air Pollution: The Ultrafine Particle Hypothesis. J of Aerosol Med 13: 355-359. doi: 10.1089/jam.2000.13.355
    [15] Zhang Q, Stanier C, Canagaratna M, et al. (2004) Insights into the chemistry of new particle formation and growth events in Pittsburgh based on aerosol mass spectrometry. Environ Sci Tech 38: 4797-4809. doi: 10.1021/es035417u
    [16] Wu J, Wang C, Sun J, et al. (2011) Neurotoxicity of silica nanoparticles: brain localization and dopaminergic neurons damage pathways. ACS Nano 5: 4476-4489. doi: 10.1021/nn103530b
    [17] Peters A, von Klot S, Heier M, et al. (2004) Exposure to Traffic and the Onset of Myocardial Infarction. N Engl J Med 351: 1721-1730. doi: 10.1056/NEJMoa040203
    [18] Roorda-Knape MC, Janssen NA, De Hartog JJ, et al. (1998) Air pollution from traffic in city districts near major motorways. Atmos Environ 32: 1921-1930. doi: 10.1016/S1352-2310(97)00496-2
    [19] Janssen NA, van Vliet PH, Aarts F (2001) Assessment of exposure to traffic related air pollution of children attending schools near motorways. Atmos Environ 35: 3875-3884. doi: 10.1016/S1352-2310(01)00144-3
    [20] Shah PS, Balkhair T (2011) Knowledge Synthesis Group on Determinants of Preterm/LBW births. Air pollution and birth outcomes: a systematic review. Environ Int 37: 498-516.
    [21] Hansen CA, Barnett AG, Pritchard G (2008) The effect of ambient air pollution during early pregnancy on fetal ultrasonic measurements during mid-pregnancy. Environ Health Perspect116: 362-369.
    [22] Iñiguez C, Ballester F, Estarlich M, et al. (2012) Prenatal exposure to traffic-related air pollution and fetal growth in a cohort of pregnant women. Occup Environ Med 69: 736-744. doi: 10.1136/oemed-2011-100550
    [23] van den Hooven EH, Pierik FH, de Kluizenaar Y, et al. (2012) Air pollution exposure during pregnancy, ultrasound measures of fetal growth, and adverse birth outcomes: a prospective cohort study. Environ Health Perspect 120: 150-156.
    [24] Ritz B, Yu F, Chapa G, et al. (2000) Effect of air pollution on preterm birth among children born in southern California between 1989 and 1993. Epidemiology 11: 502-511. doi: 10.1097/00001648-200009000-00004
    [25] Ritz B, Yu F, Fruin S, et al. (2002) Ambient air pollution and risk of birth defects in Southern California. Am J Epidemiol 155: 17-25. doi: 10.1093/aje/155.1.17
    [26] Kannan S, Misra DP, Dvonch JT, et al. (2006) Exposures to airborne particulate matter and adverse perinatal outcomes: a biologically plausible mechanistic framework for exploring potential effect modification by nutrition. Environ Health Perspect 114: 1636-1642.
    [27] Sun Q, Yue P, Deiuliis JA, et al. (2009) Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. Circulation 119: 538-546. doi: 10.1161/CIRCULATIONAHA.108.799015
    [28] Brook RD, Jerrett M, Brook, et al. (2008) The relationship between diabetes mellitus and traffic-related air pollution. Int J Occup Environ Med 50: 32-38. doi: 10.1097/JOM.0b013e31815dba70
    [29] Chen JC, Schwartz J (2008) Metabolic syndrome and inflammatory responses to long-term particulate air pollutants. Environ Health Perspect 116: 612-617. doi: 10.1289/ehp.10565
    [30] Marcelis M, Takei N, van Os J (1999) Urbanization and risk for schizophrenia: does the effect operate before or around the time of illness onset? Psychol Med 29: 1197-203. doi: 10.1017/S0033291799008983
    [31] Volk HE, Lurmann F, Penfold B, et al. (2013) Traffic-related air pollution, particulate matter, and autism. JAMA Psych 70: 71-77. doi: 10.1001/jamapsychiatry.2013.266
    [32] Perera FP, Tang D, Wang S, et al. (2012) Prenatal polycyclic aromatic hydrocarbon (PAH) exposure and child behavior at age 6-7 years. Environ Health Perspect 120: 921-926. doi: 10.1289/ehp.1104315
    [33] Volk HE, Hertz-Picciotto I, Delwiche L, et al. (2011) Residential proximity to freeways and autism in the CHARGE study. Environ Health Perspect 119: 873-877.
    [34] Roberts AL, Lyall K, Hart JE, et al. (2013) Perinatal air pollutant exposures and autism spectrum disorder in the children of nurses' health study II participants. Environ Health Perspect121: 978-984.
    [35] Kalkbrenner AE, Daniels JL, Chen JC, et al. (2010) Perinatal exposure to hazardous air pollutants and autism spectrum disorders at age 8. Epidemiology 21: 631-641. doi: 10.1097/EDE.0b013e3181e65d76
    [36] Guxens M, Aguilera I, Ballester F, et al. (2012) Prenatal exposure to residential air pollution and infant mental development: Modulation by antioxidants and detoxification factors. Environ Health Perspect 1201: 144-149
    [37] Perera FP, Rauh V, Whyatt RM, et al. (2006) Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner-city children. Environ Health Perspect 114: 1287-1292. doi: 10.1289/ehp.9084
    [38] Perera FP, Rauh V, Tsai WY, et al. (2003)Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population. Environ Health Perspect 111: 201-205.
    [39] Yokota S, Mizuo K, Moriya N, et al. (2009) Effect of prenatal exposure to diesel exhaust on dopaminergic system in mice. Neurosci Lett 449: 38-41. doi: 10.1016/j.neulet.2008.09.085
    [40] Hougaard KS, Jensen KA, Nordly P, et al. (2008) Effects of prenatal exposure to diesel exhaust particles on postnatal development, behavior, genotoxicity and inflammation in mice. Part Fibre Toxicol 5: 3. doi: 10.1186/1743-8977-5-3
    [41] Hougaard KS, Saber AT, Jensen KA, et al. (2009) Diesel exhaust particles: effects on neurofunction in female mice. Basic Clin Pharmacol Toxicol 105: 139-143. doi: 10.1111/j.1742-7843.2009.00407.x
    [42] Demokritou P, Gupta T, Ferguson S, et al. (2003) Development of a high-volume concentrated ambient particle system (CAPS) for human and animal inhalation toxicological studies. Inhal Toxicol 15: 111-129 doi: 10.1080/08958370304475
    [43] Morgan TE, Davis DA, Iwata N, et al. (2011) Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro. Environ Health Perspect 119:1003-1009. doi: 10.1289/ehp.1002973
    [44] Daher N, Hasheminassab S, Shafer MM (2013) Seasonal and spatial variability in chemical composition and mass closure of ambient ultrafine particles in the megacity of Los Angeles. Environ Sci Process Impacts 15: 283-295. doi: 10.1039/C2EM30615H
    [45] Saffari A, Daher N, Shafer MM (2014) Seasonal and spatial variation in dithiothreitol (DTT) activity of quasi-ultrafine particles in the Los Angeles Basin and its association with chemical species. J Environ Sci Health A Tox Hazard Subst Environ Eng 49: 441-451. doi: 10.1080/10934529.2014.854677
    [46] Fujimoto A, Tsukue N, Watanabe M, et al. (2005) Diesel exhaust affects immunological action in the placentas of mice. Environ Toxicol 20: 431-440. doi: 10.1002/tox.20129
    [47] Auten RL, Gilmour MI, Krantz QT, et al. (2012) Maternal diesel inhalation increases airway hyperreactivity in ozone-exposed offspring. Am J Respir Cell Mol Biol 46: 454-460. doi: 10.1165/rcmb.2011-0256OC
    [48] Bolton JL, Smith SH, Huff NC, et al. (2012) Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner. FASEB J 26: 4743-4754. doi: 10.1096/fj.12-210989
    [49] Wei Y, Zhang J, Li Z. Chronic exposure to Beijing’s air pollution increases the risk of obesity and metabolic syndrome [unpublished].
    [50] Ornoy A (2011) Prenatal origin of obesity and their complications: gestational diabetes, maternal overweight and the paradoxical effects of fetal growth restriction and macrosomia. Reprod Toxicol 32: 205
    [51] Bolton JL, Auten RL, Bilbo SD (2014) Prenatal air pollution exposure induces sexually dimorphic fetal programming of metabolic and neuroinflammatory outcomes in adult offspring. Brain Behav Immun 37: 30-44. doi: 10.1016/j.bbi.2013.10.029
    [52] Sun Q, Wang A, Jin X, et al. (2005) Long-term Air Pollution Exposure and Acceleration of Atherosclerosis and Vascular Inflammation in an Animal Model. JAMA 294: 3003-3010. doi: 10.1001/jama.294.23.3003
    [53] Allen JL, Liu X, Weston D, et al. (2014) Developmental exposure to concentrated ambient ultrafine particulate matter air pollution in mice results in persistent and sex-dependent behavioral neurotoxicity and glial activation. Toxicol Sci 140: 160-178. doi: 10.1093/toxsci/kfu059
    [54] Davis DA, Bortolato M, Godar SC, et al. (2013) Prenatal Exposure to Urban Air Nanoparticles in Mice Causes Altered Neuronal Differentiation and Depression-Like Responses. PLoS ONE 8: e64128. doi: 10.1371/journal.pone.0064128
    [55] Dunlop BW, Nemeroff CB (2007) The role of dopamine in the pathophysiology of depression. Arch Gen Psychiatry 64: 327-337. doi: 10.1001/archpsyc.64.3.327
    [56] Yang TT, Simmons AN, Matthews SC, et al. (2010) Adolescents with major depression demonstrate increased amygdala activation. J Am Acad Child Adolesc Psychiatry 49: 42-51.
    [57] Yokota S, Moriya N, Iwata M, et al. (2013) Exposure to diesel exhaust during fetal period affects behavior and neurotransmitters in male offspring mice. J Toxicol Sci 38: 13-23 doi: 10.2131/jts.38.13
    [58] Allen JL, Liu X, Pelkowski S, et al. (2014) Early postnatal exposure to ultrafine particulate matter air pollution: persistent ventriculomegaly, neurochemical disruption, and glial activation preferentially in male mice. Environ Health Perspect 122: 939-945.
    [59] Rice D, Barone Jr S (2000) Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ Health Perspect 108: 511. doi: 10.1289/ehp.00108s3511
    [60] Block ML, Calderón-Garcidueñas L. (2009) Air pollution: mechanisms of neuroinflammation and CNS disease. Trends Neurosci 32: 506-516. doi: 10.1016/j.tins.2009.05.009
    [61] Zou JY, Crews FT (2005) TNFα potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NFκB inhibition. Brain Res 1034:11-24. doi: 10.1016/j.brainres.2004.11.014
    [62] Suzuki T, Oshio S, Iwata M, et al. (2010) In utero exposure to a low concentration of diesel exhaust affects spontaneous locomotor activity and monoaminergic system in male mice. Part Fibre Toxicol 7: 7. doi: 10.1186/1743-8977-7-7
    [63] Park EJ, Bae E, Yi J, et al. (2010) Repeated-dose toxicity and inflammatory responses in mice by oral administration of silver nanoparticles. Environ Toxicol Pharmacol 30: 162-168. doi: 10.1016/j.etap.2010.05.004
    [64] Onoda A, Umezawa M, Takeda K, et al. (2014) Effects of maternal exposure to ultrafine carbon black on brain perivascular macrophages and surrounding astrocytes in offspring mice. PLoS ONE 9: e94336. doi: 10.1371/journal.pone.0094336
    [65] Aaltonen R, Heikkinen T, Hakala K, et al. (2005) Transfer of proinflammatory cytokines across term placenta. Obstet Gynecol 106: 802-807. doi: 10.1097/01.AOG.0000178750.84837.ed
    [66] Bolton JL, Huff NC, Smith SH, et al. (2013) Maternal stress and effects of prenatal air pollution on offspring mental health outcomes in mice. Environ Health Perspect 121: 1075-1082.
    [67] Stolp HB, Liddelow SA, Sá-Pereira I (2013) Immune responses at brain barriers and implications for brain development and neurological function in later life. Front Integr Neurosci7: 61
    [68] Takeda K, Suzuki K, Ishihara A, et al. (2009) Nanoparticles transferred from pregnant mice to their offspring can damage the genital and cranial nerve systems. J Health Sci 55: 95-102 doi: 10.1248/jhs.55.95
    [69] Wick P, Malek A, Manser P, et al. (2010) Barrier capacity of human placenta for nanosized materials. Environ Health Perspect 118: 432-436. doi: 10.1289/ehp.118-a432
    [70] Nel AE, Mädler L, Velegol D, et al. (2009) Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater 8: 543-557. doi: 10.1038/nmat2442
    [71] Kim YS, Song MY, Park JD, et al. (2010) Subchronic oral toxicity of silver nanoparticles. Part Fibre Toxicol 7: 20. doi: 10.1186/1743-8977-7-20
    [72] Choi HS, Ashitate Y, Lee JH, et al. (2010) Rapid translocation of nanoparticles from the lung airspaces to the body. Nat Biotechnol 28: 1300-1303. doi: 10.1038/nbt.1696
    [73] Schleh C, Semmler-Behnke M, Lipka J, et al. (2012) Size and surface charge of gold nanoparticles determine absorption across intestinal barriers and accumulation in secondary target organs after oral administration. Nanotoxicology 6: 36-46. doi: 10.3109/17435390.2011.552811
    [74] Sood A, Salih S, Roh D, et al. (2011) Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness. Nature Nanotechnol 6: 824-833. doi: 10.1038/nnano.2011.188
    [75] Bilbo SD, Schwarz JM (2012) The immune system and developmental programming of brain and behavior. Front Neuroendocrinol 33: 267-286. doi: 10.1016/j.yfrne.2012.08.006
    [76] Yusof AF, Mamat R, Hafzil M (2013) Comparative study of particulate matter (PM) emissions in diesel engine using diesel-methanol blends, Appl Mech Mater 465: 1255-1261.
    [77] Sugamata M, Ihara T, Sugamata M, et al. (2006) Maternal exposure to diesel exhaust leads to pathological similarity to autism in newborns. J Health Sci 4: 486-488
    [78] Umezawa M, Sakata C, Tanaka N, et al. (2011) Pathological study for the effects of in utero and postnatal exposure to diesel exhaust on a rat endometriosis model. J Toxicol Sci 36: 493-498. doi: 10.2131/jts.36.493
    [79] Allen JL, Conrad K, Oberdörster G, et al. (2013) Developmental exposure to concentrated ambient particles and preference for immediate reward in mice. Environ Health Perspect 121: 32-38. doi: 10.1289/ehp.121-a32
  • Reader Comments
  • © 2015 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
AIMS Environmental Science
1.6 2.9

Metrics

Article views(8605) PDF downloads(1517) Cited by(39)

Preview PDF
Download XML
Export Citation
Article outline

Figures and Tables

Tables(6)

Other Articles By Authors

Related pages

Tools

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return

Catalog