Potential of biosurfactant as green pharmaceutical excipients for coating of microneedles: A mini review

Marzieh Sajadi Bami; Payam Khazaeli; Shayan Fakhraei Lahiji; Gholamreza Dehghannoudeh; Ibrahim M. Banat; Mandana Ohadi; Marzieh Sajadi Bami; Payam Khazaeli; Shayan Fakhraei Lahiji; Gholamreza Dehghannoudeh; Ibrahim M. Banat; Mandana Ohadi

doi:10.3934/microbiol.2024028

AIMS Microbiology

2024, Volume 10, Issue 3: 596-607. doi: 10.3934/microbiol.2024028

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Mini review

Potential of biosurfactant as green pharmaceutical excipients for coating of microneedles: A mini review

1.
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
2.
Department of Bioengineering, Biopharmaceutical Research Laboratory, Hanyang University, Seoul, South Korea
3.
School of Biomedical Sciences, Faculty of Life & Health Sciences, Ulster University, Coleraine BT52 1SA, Northern Ireland, UK

Received: 14 May 2024 Revised: 21 July 2024 Accepted: 25 July 2024 Published: 30 July 2024

Microneedles, a novel transdermal delivery system, were designed to improve drug delivery and address the challenges typically encountered with traditional injection practices. Discovering new and safe excipients for microneedle coating to replace existing chemical surfactants is advantageous to minimize their side effect on viable tissues. However, some side effects have also been observed for this application. The vast majority of studies suggest that using synthetic surfactants in microneedle formulations may result in skin irritation among other adverse effects. Hence, increasing knowledge about these components and their potential impacts on skin paves the way for finding preventive strategies to improve their application safety and potential efficacy. Biosurfactants, which are naturally produced surface active microbial products, are proposed as an alternative to synthetic surfactants with reduced side effects. The current review sheds light on potential and regulatory aspects of biosurfactants as safe excipients in the coating of microneedles.
- biosurfactants,
- green pharmaceutical,
- excipients,
- microneedles,
- coating method
Citation: Marzieh Sajadi Bami, Payam Khazaeli, Shayan Fakhraei Lahiji, Gholamreza Dehghannoudeh, Ibrahim M. Banat, Mandana Ohadi. Potential of biosurfactant as green pharmaceutical excipients for coating of microneedles: A mini review[J]. AIMS Microbiology, 2024, 10(3): 596-607. doi: 10.3934/microbiol.2024028

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Abstract

Microneedles, a novel transdermal delivery system, were designed to improve drug delivery and address the challenges typically encountered with traditional injection practices. Discovering new and safe excipients for microneedle coating to replace existing chemical surfactants is advantageous to minimize their side effect on viable tissues. However, some side effects have also been observed for this application. The vast majority of studies suggest that using synthetic surfactants in microneedle formulations may result in skin irritation among other adverse effects. Hence, increasing knowledge about these components and their potential impacts on skin paves the way for finding preventive strategies to improve their application safety and potential efficacy. Biosurfactants, which are naturally produced surface active microbial products, are proposed as an alternative to synthetic surfactants with reduced side effects. The current review sheds light on potential and regulatory aspects of biosurfactants as safe excipients in the coating of microneedles.

Acknowledgments

The authors would like to thank the Kerman University of Medical Sciences (KMU) for facilitating research into this study.

Conflict of interest

Ibrahim M. Banat is an editorial boardmember for AIMS Microbiology and was not involved inthe editorial review or the decision to publish this article. All authors declare that there are no competing interests.

Author contributions

Marzieh Sajadi Bami, Payam Khazaeli, Mandana Ohadi, and Shayan Fakhraei Lahiji provided the general concept and wrote the manuscript. Marzieh Sajadi Bami and Gholamreza Dehghannoudeh prepared table and edited the text. Ibrahim M. Banat and Mandana Ohadi revised the manuscript and provided further editing and concepts. All authors have read and agreed to the published version of the manuscript.

References

[1]	Kirkby M, Moffatt KJ, Hutton AR, et al. (2021) Assessment of microneedles for transdermal drug delivery. Percutaneous Absorption. Boca Raton: CRC Press 543-576. https://doi.org/10.1201/9780429202971-39
[2]	Ma Y, Li CG, Kim S, et al. (2018) An insulin microneedle pen (imp) for self-subcutaneous insulin injection. Adv Mater Technol 3: 1800234. https://doi.org/10.1002/admt.201800234
[3]	Gill HS, Prausnitz MR (2007) Coated microneedles for transdermal delivery. J Control Release 117: 227-237. https://doi.org/10.1016/j.jconrel.2006.10.017
[4]	Guillot AJ, Cordeiro AS, Donnelly RF, et al. (2020) Microneedle-based delivery: An overview of current applications and trends. Pharmaceutics 12: 569. https://doi.org/10.3390/pharmaceutics12060569
[5]	Ingrole RS, Gill HS (2019) Microneedle coating methods: A review with a perspective. J Pharmacol Exp Ther 370: 555-569. https://doi.org/10.1124/jpet.119.258707
[6]	Tucak A, Sirbubalo M, Hindija L, et al. (2020) Microneedles: Characteristics, materials, production methods and commercial development. Micromachines 11: 961. https://doi.org/10.3390/mi11110961
[7]	Bejeshk MA, Rajizadeh MA, Yari A, et al. (2024) Lipopeptide biosurfactant produced by Acinetobacter junii B6 attenuates lung inflammatory, oxidative, and histopathological alterations due to asthma in rats. Int J Pept Res Ther 30: 9. https://doi.org/10.1007/s10989-024-10586-x
[8]	Levis S, Deasy P (2001) Pharmaceutical applications of size reduced grades of surfactant co-processed microcrystalline cellulose. Int J Pharm 230: 25-33. https://doi.org/10.1016/s0378-5173%2801%2900843-2
[9]	Adu SA, Twigg MS, Naughton PJ, et al. (2023) Characterisation of cytotoxicity and immunomodulatory effects of glycolipid biosurfactants on human keratinocytes. Appl Microbiol Biotechnol 107: 137-152. https://doi.org/10.1007/s00253-022-12302-5
[10]	Han M, Hyun DH, Park HH, et al. (2007) A novel fabrication process for out-of-plane microneedle sheets of biocompatible polymer. J Micromech Microeng 17: 1184. https://doi.org/10.1088/0960-1317/17/6/012
[11]	Gupta N, Gupta A (2021) A review on herbal excipients. Int J indig herbs drugs 6: 05-08. https://doi.org/10.46956/ijihd.vi.111
[12]	Manga EB, Celik PA, Cabuk A, et al. (2021) Biosurfactants: Opportunities for the development of a sustainable future. Curr Opin Colloid Interface Sci 56: 101514. https://doi.org/10.1016/j.cocis.2021.101514
[13]	Marchant R, Banat IM (2012) Biosurfactants: A sustainable replacement for chemical surfactants?. Biotechnol Lett 34: 1597-1605. https://doi.org/10.1007/s10529-012-0956-x
[14]	Afsharipour S, Kavianipoor S, Ranjbar M, et al. (2023) Fabrication and characterization of lipopeptide biosurfactant-based electrospun nanofibers for use in tissue engineering. Ann Pharm Fr 81: 968-976. https://doi.org/10.1016/j.pharma.2023.08.008
[15]	Sałek K, Euston SR (2019) Sustainable microbial biosurfactants and bioemulsifiers for commercial exploitation. Process Biochem 85: 143-155. https://doi.org/10.1016/j.procbio.2019.06.027
[16]	Liu K, Sun Y, Cao M, et al. (2020) Rational design, properties, and applications of biosurfactants: A short review of recent advances. Curr Opin Colloid Interface Sci 45: 57-67. https://doi.org/10.1016/j.cocis.2019.12.005
[17]	Groenendijk DJ, van Wunnik JN (2021) The impact of micelle formation on surfactant adsorption–desorption. ACS omega 6: 2248-2254. https://doi.org/10.1021/acsomega.0c05532
[18]	Serri C, de Gennaro B, Catalanotti L, et al. (2016) Surfactant-modified phillipsite and chabazite as novel excipients for pharmaceutical applications?. Microporous Mesoporous Mater 224: 143-148. https://doi.org/10.1016/j.micromeso.2015.11.023
[19]	Abruzzo A, Parolin C, Corazza E, et al. (2021) Influence of lactobacillus biosurfactants on skin permeation of hydrocortisone. Pharmaceutics 13: 820. https://doi.org/10.3390/pharmaceutics13060820
[20]	Jozanović M, Sakač N, Karnaš M, et al. (2021) Potentiometric sensors for the determination of anionic surfactants–A review. Crit Rev Anal Chem 51: 115-137. https://doi.org/10.1080/10408347.2019.1684236
[21]	Aguirre-Ramírez M, Silva-Jiménez H, Banat IM, et al. (2021) Surfactants: physicochemical interactions with biological macromolecules. Biotechnol Lett 43: 523-535. https://doi.org/10.1007/s10529-020-03054-1
[22]	Ceresa C, Fracchia L, Sansotera AC, et al. (2023) Harnessing the potential of biosurfactants for biomedical and pharmaceutical applications. Pharmaceutics 15: 2156. https://doi.org/10.3390/pharmaceutics15082156
[23]	Koehl NJ, Holm R, Kuentz M, et al. (2020) Exploring the impact of surfactant type and digestion: Highly digestible surfactants improve oral bioavailability of nilotinib. Mol Pharmaceutics 17: 3202-3213. https://doi.org/10.1021/acs.molpharmaceut.0c00305
[24]	Jahan R, Bodratti AM, Tsianou M, et al. (2020) Biosurfactants, natural alternatives to synthetic surfactants: Physicochemical properties and applications. Adv Colloid Interface Sci 275: 102061. https://doi.org/10.1016/j.cis.2019.102061
[25]	Cortés H, Hernández-Parra H, Bernal-Chávez SA, et al. (2021) Non-ionic surfactants for stabilization of polymeric nanoparticles for biomedical uses. Materials 14: 3197. https://doi.org/10.3390/ma14123197
[26]	Muhammed NS, Olayiwola T, Elkatatny S, et al. (2021) Insights into the Application of surfactants and nanomaterials as shale inhibitors for water-based drilling fluid: A review. J Nat Gas Sci Eng : 103987. https://doi.org/10.1016/j.jngse.2021.10398727
[27]	Markande AR, Patel D, Varjani S (2021) A review on biosurfactants: properties, applications and current developments. Bioresour Technol 124963. https://doi.org/10.1016/j.biortech.2021.124963
[28]	Bami MS, Khazaeli P, Forootanfar H, et al. (2020) Isolation and identification of biosurfactant producing bacterial strain from saline soil samples in iran; evaluation of factors on biosurfactant production. Jundishapur J Nat Pharm Prod 15. https://doi.org/10.5812/jjnpp.96798
[29]	Elsoud MMAA (2021) Classification and production of microbial surfactants. Microbial Biosurfactants: Environmental and Microbial Biotechnology. Singapore: Springer 65-89. https://doi.org/10.1007/978-981-15-6607-3_4
[30]	De S, Malik S, Ghosh A, et al. (2015) A review on natural surfactants. RSC advances 5: 65757-65767. https://doi.org/10.1039/c5ra11101c
[31]	Marchant R, Banat IM (2012) Microbial biosurfactants: challenges and opportunities for future exploitation. Trends Biotechnol 30: 558-565. https://doi.org/10.1016/j.tibtech.2012.07.003
[32]	Imam A, Suman SK, Kanaujia PK, et al. (2021) Biological machinery for polycyclic aromatic hydrocarbons degradation: A review. Bioresour Technol 126121. https://doi.org/10.1016/j.biortech.2021.126121
[33]	Puyol McKenna P, Naughton PJ, Dooley JS, et al. (2024) Microbial biosurfactants: antimicrobial activity and potential biomedical and therapeutic exploits. Pharmaceuticals 17: 138. https://doi.org/10.3390/ph17010138
[34]	Sarubbo LA, Maria da Gloria CS, Durval IJB, et al. (2022) Biosurfactants: Production, properties, applications, trends, and general perspectives. Biochem Eng J 181: 108377. https://doi.org/10.1016/j.bej.2022.108377
[35]	Ceresa C, Fracchia L, Fedeli E, et al. (2021) Recent advances in biomedical, therapeutic and pharmaceutical applications of microbial surfactants. Pharmaceutics 13: 466. https://doi.org/10.3390/pharmaceutics13040466
[36]	Al-Wahaibi Y, Joshi S, Al-Bahry S, et al. (2014) Biosurfactant production by Bacillus subtilis B30 and its application in enhancing oil recovery. Colloids Surf B Biointerfaces 114: 324-333. https://doi.org/10.1016/j.colsurfb.2013.09.022
[37]	Kumar PS, Ngueagni PT (2021) A review on new aspects of lipopeptide biosurfactant: Types, production, properties and its application in the bioremediation process. J Hazard Mater 407: 124827. https://doi.org/10.1016/j.jhazmat.2020.124827
[38]	López-Prieto A, Moldes AB, Cruz JM, et al. (2020) Towards more ecofriendly pesticides: use of biosurfactants obtained from the corn milling industry as solubilizing agent of copper oxychloride. J Surfactants Deterg 23: 1055-1066. https://doi.org/10.1002/jsde.12463
[39]	Hu X, Qiao Y, Chen LQ, et al. (2020) Enhancement of solubilization and biodegradation of petroleum by biosurfactant from Rhodococcus erythropolis HX-2. Geomicrobiol J 37: 159-169. https://doi.org/10.1080/01490451.2019.1678702
[40]	Gupta S, Raghuwanshi N, Varshney R, et al. (2017) Accelerated in vivo wound healing evaluation of microbial glycolipid containing ointment as a transdermal substitute. Biomed Pharmacother 94: 1186-1196. https://doi.org/10.1016/j.biopha.2017.08.010
[41]	Adu SA, Naughton PJ, Marchant R, et al. (2020) Microbial biosurfactants in cosmetic and personal skincare pharmaceutical formulations. Pharmaceutics 12: 1099. https://doi.org/10.3390/pharmaceutics12111099
[42]	Bezerra KGO, Rufino RD, Luna JM, et al. (2018) Saponins and microbial biosurfactants: Potential raw materials for the formulation of cosmetics. Biotechnol Prog 34: 1482-1493. https://doi.org/10.1002/btpr.2682
[43]	Naughton P, Marchant R, Naughton V, et al. (2019) Microbial biosurfactants: current trends and applications in agricultural and biomedical industries. J Appl Microbiol 127: 12-28. https://doi.org/10.1111/jam.14243
[44]	de Gusmao CA, Rufino RD, Sarubbo LA (2010) Laboratory production and characterization of a new biosurfactant from Candida glabrata UCP1002 cultivated in vegetable fat waste applied to the removal of hydrophobic contaminant. World J Microbiol Biotechnol 26: 1683-1692. https://doi.org/10.1007/s11274-010-0346-2
[45]	Solaiman D, Ashby R, Birbir M, et al. (2016) Antibacterial activity of sophorolipids produced by Candida bombicola Gram-positive and Gram-negative bacteria isolated from salted hides. J Am Leather Chem Assoc 111: 358-364. Available from: https://journals.uc.edu/index.php/JALCA/article/view/3644/2836
[46]	Adu SA, Twigg MS, Naughton PJ, et al. (2023) Purified Acidic sophorolipid biosurfactants in skincare applications: An assessment of cytotoxic effects in comparison with synthetic surfactants using a 3D in vitro human skin model. Fermentation 9: 985. https://doi.org/10.3390/fermentation9110985
[47]	Kim CH, Lee DW, Heo YM, et al. (2019) Desorption and solubilization of anthracene by a rhamnolipid biosurfactant from Rhodococcus fascians. Water Environ Res 91: 739-747. https://doi.org/10.1002/wer.1103
[48]	Elshikh M, Moya-Ramírez I, Moens H, et al. (2017) Rhamnolipids and lactonic sophorolipids: natural antimicrobial surfactants for oral hygiene. J Appl Microbiol 123: 1111-1123. https://doi.org/10.1111/jam.13550
[49]	Morikawa M, Daido H, Takao T, et al. (1993) A new lipopeptide biosurfactant produced by Arthrobacter sp. strain MIS38. J Bacteriol 175: 6459-6466. https://doi.org/10.1128/jb.175.20.6459-6466.1993
[50]	De Gregorio PR, Parolin C, Abruzzo A, et al. (2020) Biosurfactant from vaginal Lactobacillus crispatus BC1 as a promising agent to interfere with Candida adhesion. Microb cell fact 19: 1-16. https://doi.org/10.1186/s12934-020-01390-5
[51]	Meena KR, Sharma A, Kanwar SS (2020) Antitumoral and antimicrobial activity of surfactin extracted from Bacillus subtilis KLP2015. Int J Pept Res Ther 26: 423-433. https://doi.org/10.1007/s10989-019-09848-w
[52]	Kapoor D, Maheshwari R, Verma K, et al. (2020) Coating technologies in pharmaceutical product development. Drug Delivery Systems. New York: Academic Press 665-719. https://doi.org/10.1016/b978-0-12-814487-9.00014-4
[53]	Ruba I, Zain B, Ildikó C (2021) Regulatory status quo and prospects for biosurfactants in pharmaceutical applications. Drug Discov Today 26: 1929-1935. https://doi.org/10.1016/j.drudis.2021.03.029
[54]	DeMerlis C, Goldring J, Velagaleti R, et al. (2009) Regulatory update: the IPEC novel excipient safety evaluation procedure. Pharm Technol 33: 72-82. Available from: https://www.pharmtech.com/view/regulatory-update-ipec-novel-excipient-safety-evaluation-procedure
[55]	Saluja V, Sekhon BS (2016) The regulation of pharmaceutical excipients. J Excip Food Chem 4: 1049. Available from: https://jefc.scholasticahq.com/article/1049
[56]	Ohadi M, Dehghannoudeh G, Shakibaie M, et al. (2017) Isolation, characterization, and optimization of biosurfactant production by an oil-degrading Acinetobacter junii B6 isolated from an Iranian oil excavation site. Biocatal Agric Biotechnol 12: 1-9. https://doi.org/10.1016/j.bcab.2017.08.007
[57]	Adu SA, Twigg MS, Naughton PJ, et al. (2022) Biosurfactants as anticancer agents: Glycolipids affect skin cells in a differential manner dependent on chemical structure. Pharmaceutics 14: 360. https://doi.org/10.3390/pharmaceutics14020360
[58]	Rodríguez-López L, Shokry DS, Cruz JM, et al. (2019) The effect of the presence of biosurfactant on the permeation of pharmaceutical compounds through silicone membrane. Colloids Surf B Biointerfaces 176: 456-461. https://doi.org/10.1016/j.colsurfb.2018.12.072
[59]	Bjerk TR, Severino P, Jain S, et al. (2021) Biosurfactants: Properties and applications in drug delivery, biotechnology and ecotoxicology. Bioengineering 8: 115. https://doi.org/10.3390/bioengineering8080115

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