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AIMS Microbiology

2023, Volume 9, Issue 4: 612-646. doi: 10.3934/microbiol.2023032
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Review

P. aeruginosa interactions with other microbes in biofilms during co-infection

  • 1.
    CIISA—Center for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Avenida da Universidade Técnica, 1300-477 Lisboa, Portugal
  • 2.
    Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), 1300-477 Lisboa, Portugal
  • Received: 15 June 2023 Revised: 10 July 2023 Accepted: 26 July 2023 Published: 10 August 2023

  • This review addresses the topic of biofilms, including their development and the interaction between different counterparts. There is evidence that various diseases, such as cystic fibrosis, otitis media, diabetic foot wound infections, and certain cancers, are promoted and aggravated by the presence of polymicrobial biofilms. Biofilms are composed by heterogeneous communities of microorganisms protected by a matrix of polysaccharides. The different types of interactions between microorganisms gives rise to an increased resistance to antimicrobials and to the host's defense mechanisms, with the consequent worsening of disease symptoms. Therefore, infections caused by polymicrobial biofilms affecting different human organs and systems will be discussed, as well as the role of the interactions between the gram-negative bacteria Pseudomonas aeruginosa, which is at the base of major polymicrobial infections, and other bacteria, fungi, and viruses in the establishment of human infections and diseases. Considering that polymicrobial biofilms are key to bacterial pathogenicity, it is fundamental to evaluate which microbes are involved in a certain disease to convey an appropriate and efficacious antimicrobial therapy.

    Citation: Manuela Oliveira, Eva Cunha, Luís Tavares, Isa Serrano. P. aeruginosa interactions with other microbes in biofilms during co-infection[J]. AIMS Microbiology, 2023, 9(4): 612-646. doi: 10.3934/microbiol.2023032

    Related Papers:

  • This review addresses the topic of biofilms, including their development and the interaction between different counterparts. There is evidence that various diseases, such as cystic fibrosis, otitis media, diabetic foot wound infections, and certain cancers, are promoted and aggravated by the presence of polymicrobial biofilms. Biofilms are composed by heterogeneous communities of microorganisms protected by a matrix of polysaccharides. The different types of interactions between microorganisms gives rise to an increased resistance to antimicrobials and to the host's defense mechanisms, with the consequent worsening of disease symptoms. Therefore, infections caused by polymicrobial biofilms affecting different human organs and systems will be discussed, as well as the role of the interactions between the gram-negative bacteria Pseudomonas aeruginosa, which is at the base of major polymicrobial infections, and other bacteria, fungi, and viruses in the establishment of human infections and diseases. Considering that polymicrobial biofilms are key to bacterial pathogenicity, it is fundamental to evaluate which microbes are involved in a certain disease to convey an appropriate and efficacious antimicrobial therapy.


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    Acknowledgments


    Authors would like to acknowledge CIISA—Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Universidade de Lisboa, Lisboa, Portugal and Laboratório Associado para a Ciência Animal e Veterinária.

    Conflict of interest


    The authors declare no conflict of interest.

    Author contributions


    Conceptualization, M.O., E.C., L.T., and I.S.; Writing—original draft preparation, I.S.; Writing—review and editing, M.O., E.C., L.T., and I.S.; Visualization, I.S.; Project administration, L.T. and M.O.

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