RodZ: a key-player in cell elongation and cell division in <em>Escherichia coli</em>

Risa Ago; Daisuke Shiomi; Risa Ago; Daisuke Shiomi

doi:10.3934/microbiol.2019.4.358

AIMS Microbiology

2019, Volume 5, Issue 4: 358-367. doi: 10.3934/microbiol.2019.4.358

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Mini review Special Issues

RodZ: a key-player in cell elongation and cell division in Escherichia coli

Risa Ago ,
Daisuke Shiomi ^,

Department of Life Science, College of Science, Rikkyo University, 3-34-1 Nishi Ikebukuro, Toshima-ku, Tokyo 171-8501, Japan

Received: 28 August 2019 Accepted: 06 November 2019 Published: 07 November 2019

RodZ is required for determination of cell shape in rod-shaped bacterium, such as Escherichia coli. RodZ is a transmembrane protein and forms a supramolecular complex called the Rod complex with other proteins, such as MreB-actin and peptidoglycan synthesis enzymes (for e.g., PBP2). Deletion of the rodZ gene changes the cell shape from rod to round or ovoid. Another supramolecular complex called divisome that controls cell division mainly consists of FtsZ-tubulin. MreB directly interacts with FtsZ and this interaction is critical to trigger a transition from cell elongation to cell division. Recently, we found that RodZ also directly interacts with FtsZ, and RodZ recruits MreB to the divisome. Formation of the division ring, called Z ring, is delayed if RodZ does not interact with FtsZ, indicating that RodZ might facilitate the formation of the Z ring during the cell division process. In this mini-review, we have summarized the roles of RodZ in cell elongation and cell division, especially based on our recent study.
- RodZ,
- MreB,
- FtsZ,
- peptidoglycan,
- Rod complex,
- divisome
Citation: Risa Ago, Daisuke Shiomi. RodZ: a key-player in cell elongation and cell division in Escherichia coli[J]. AIMS Microbiology, 2019, 5(4): 358-367. doi: 10.3934/microbiol.2019.4.358

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Abstract

RodZ is required for determination of cell shape in rod-shaped bacterium, such as Escherichia coli. RodZ is a transmembrane protein and forms a supramolecular complex called the Rod complex with other proteins, such as MreB-actin and peptidoglycan synthesis enzymes (for e.g., PBP2). Deletion of the rodZ gene changes the cell shape from rod to round or ovoid. Another supramolecular complex called divisome that controls cell division mainly consists of FtsZ-tubulin. MreB directly interacts with FtsZ and this interaction is critical to trigger a transition from cell elongation to cell division. Recently, we found that RodZ also directly interacts with FtsZ, and RodZ recruits MreB to the divisome. Formation of the division ring, called Z ring, is delayed if RodZ does not interact with FtsZ, indicating that RodZ might facilitate the formation of the Z ring during the cell division process. In this mini-review, we have summarized the roles of RodZ in cell elongation and cell division, especially based on our recent study.

Acknowledgments

The work on RodZ was partly carried out in Dr. Hironori Niki's lab (National Institute of Genetics, Japan). The work in our lab was supported by the JSPS KAKENHI (Grant Numbers 24770191, 25117528, 15H01333, and 15H04731) and by the NIG-JOINT (2016-A1[40], 61A2017, 57A2018, and 60A2019).

Conflict of interest

The authors declare no conflict of interest in this review.

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