Agent-based modeling for the tumor microenvironment (TME)

Hasitha N. Weerasinghe; Pamela M. Burrage; Dan V. Nicolau Jr.; Kevin Burrage; Hasitha N. Weerasinghe; Pamela M. Burrage; Dan V. Nicolau Jr.; Kevin Burrage

doi:10.3934/mbe.2024335

Mathematical Biosciences and Engineering

2024, Volume 21, Issue 11: 7621-7647. doi: 10.3934/mbe.2024335

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Agent-based modeling for the tumor microenvironment (TME)

1.
School of Mathematical Sciences, Queensland University of Technology, Queensland, Brisbane, Australia
2.
School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom
3.
Department of Computer Science, University of Oxford, United Kingdom

Academic Editor: Congping Lin

Received: 28 June 2024 Revised: 01 November 2024 Accepted: 11 November 2024 Published: 25 November 2024

Cancer is a disease that arises from the uncontrolled growth of abnormal (tumor) cells in an organ and their subsequent spread into other parts of the body. If tumor cells spread to surrounding tissues or other organs, then the disease is life-threatening due to limited treatment options. This work applies an agent-based model to investigate the effect of intra-tumoral communication on tumor progression, plasticity, and invasion, with results suggesting that cell-cell and cell-extracellular matrix (ECM) interactions affect tumor cell behavior. Additionally, the model suggests that low initial healthy cell densities and ECM protein densities promote tumor progression, cell motility, and invasion. Furthermore, high ECM breakdown probabilities of tumor cells promote tumor invasion. Understanding the intra-tumoral communication under cellular stress can potentially lead to the design of successful treatment strategies for cancer.
- tumor microenvironment,
- cancer,
- agent-based modeling,
- plasticity,
- invasion
Citation: Hasitha N. Weerasinghe, Pamela M. Burrage, Dan V. Nicolau Jr., Kevin Burrage. Agent-based modeling for the tumor microenvironment (TME)[J]. Mathematical Biosciences and Engineering, 2024, 21(11): 7621-7647. doi: 10.3934/mbe.2024335

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Abstract

Cancer is a disease that arises from the uncontrolled growth of abnormal (tumor) cells in an organ and their subsequent spread into other parts of the body. If tumor cells spread to surrounding tissues or other organs, then the disease is life-threatening due to limited treatment options. This work applies an agent-based model to investigate the effect of intra-tumoral communication on tumor progression, plasticity, and invasion, with results suggesting that cell-cell and cell-extracellular matrix (ECM) interactions affect tumor cell behavior. Additionally, the model suggests that low initial healthy cell densities and ECM protein densities promote tumor progression, cell motility, and invasion. Furthermore, high ECM breakdown probabilities of tumor cells promote tumor invasion. Understanding the intra-tumoral communication under cellular stress can potentially lead to the design of successful treatment strategies for cancer.

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