Pilot study of pressure-flow properties in a numerical model of the middle ear

Xu Bie; Yuanyuan Tang; Ming Zhao; Yingxi Liu; Shen Yu; Dong Sun; Jing Liu; Ying Wang; Jianing Zhang; Xiuzhen Sun; Xu Bie; Yuanyuan Tang; Ming Zhao; Yingxi Liu; Shen Yu; Dong Sun; Jing Liu; Ying Wang; Jianing Zhang; Xiuzhen Sun

doi:10.3934/mbe.2020131

Mathematical Biosciences and Engineering

2020, Volume 17, Issue 3: 2418-2431. doi: 10.3934/mbe.2020131

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Research article

Pilot study of pressure-flow properties in a numerical model of the middle ear

1.
Department of Otolaryngology-Head and Neck Surgery, The 2nd Affiliated Hospital to Dalian Medical University, Dalian 116027, China
2.
Department of Engineering Mechanics, Dalian University of Technology, Dalian 116024, China
3.
The No.2 Laboratory, China Helicopter Research and Development Institute, Jingdezhen 333000, China
4.
Department of Otorhinolaryngology, Xiamen Humanity Hospital, Xiamen 361006, China

Received: 10 November 2019 Accepted: 04 February 2020 Published: 17 February 2020

BackgroundConstructing a three-dimensional (3D) model through non-invasive techniques will greatly benefit the diagnosis and treatment of otitis media. However, such a model should reflect the physiological characteristics of the middle ear; in particular, the pressure-flow responses determine the validity of the model.

ObjectivesA 3D model of the middle ear was constructed by digital scanning and simulation. The pressure-flow properties in the model were measured to evaluate whether the model could reflect the real middle ear under physiological and pathological conditions.

Materials and methodsComputed tomography (CT) scanning data from a healthy woman were input into Mimics 20.0 to construct 3D images of the middle ear. The 3D images were treated with Ansys 15.0 for finite element mesh generation. Msc Nastran 2014 were used for the fluid-solid coupling calculations.

ResultsThe pressure-flow rate in the model resembled a Venturi tube, namely, the pressure decreased with increasing flow velocity, especially in the Eustachian tube. In the absence of the right mastoid process, the differences in air pressure and the maximal velocity in the model were reduced.

ConclusionsThis numerical model based on CT images of the middle ear recapitulates the biomechanical characteristics of the real middle ear.

SignificanceThis study provides an easy and rapid approach to constructing a middle ear model for diagnosis and treatment of otitis media.
- numerical simulation,
- 3D reconstruction,
- middle ear,
- air-containing model,
- solid-fluid coupling calculation
Citation: Xu Bie, Yuanyuan Tang, Ming Zhao, Yingxi Liu, Shen Yu, Dong Sun, Jing Liu, Ying Wang, Jianing Zhang, Xiuzhen Sun. Pilot study of pressure-flow properties in a numerical model of the middle ear[J]. Mathematical Biosciences and Engineering, 2020, 17(3): 2418-2431. doi: 10.3934/mbe.2020131

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Abstract

BackgroundConstructing a three-dimensional (3D) model through non-invasive techniques will greatly benefit the diagnosis and treatment of otitis media. However, such a model should reflect the physiological characteristics of the middle ear; in particular, the pressure-flow responses determine the validity of the model.

ObjectivesA 3D model of the middle ear was constructed by digital scanning and simulation. The pressure-flow properties in the model were measured to evaluate whether the model could reflect the real middle ear under physiological and pathological conditions.

Materials and methodsComputed tomography (CT) scanning data from a healthy woman were input into Mimics 20.0 to construct 3D images of the middle ear. The 3D images were treated with Ansys 15.0 for finite element mesh generation. Msc Nastran 2014 were used for the fluid-solid coupling calculations.

ResultsThe pressure-flow rate in the model resembled a Venturi tube, namely, the pressure decreased with increasing flow velocity, especially in the Eustachian tube. In the absence of the right mastoid process, the differences in air pressure and the maximal velocity in the model were reduced.

ConclusionsThis numerical model based on CT images of the middle ear recapitulates the biomechanical characteristics of the real middle ear.

SignificanceThis study provides an easy and rapid approach to constructing a middle ear model for diagnosis and treatment of otitis media.

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