Histone variant H2A.Z and transcriptional activators may antagonistically regulate flavonoid biosynthesis

Nguyen Hoai Nguyen; Nguyen Hoai Nguyen

doi:10.3934/bioeng.2020005

AIMS Bioengineering

2020, Volume 7, Issue 1: 55-59. doi: 10.3934/bioeng.2020005

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Mini review

Histone variant H2A.Z and transcriptional activators may antagonistically regulate flavonoid biosynthesis

Nguyen Hoai Nguyen ^,

Faculty of Biotechnology, Ho Chi Minh City Open University, 97 Vo Van Tan Street, District 3, Ho Chi Minh City, Vietnam

Received: 07 February 2020 Accepted: 17 March 2020 Published: 18 March 2020

Flavonoid is an important group of plant secondary metabolites. The biosynthesis of this flavonoid group can be precisely regulated by many environmental factors. Currently, histone variants have been documented as important factors in the regulation of eukaryotic gene expression. H2A.Z histone variant has been found to function in numerous plant physiological programs including flavonoid biosynthesis. Moreover, the environmental changes have been shown to significantly influence the replacement between histone proteins and their variants leading to alterations in gene expression. Based on the recent studies, this mini-review is to provide an updated view on the functions of histone variant H2A.Z in the regulation of flavonoid biosynthetic gene expression. In addition, this also suggests a model in which the H2A.Z-containing nucleosomes can be evicted upon environmental stress conditions to facilitate the targeting of transcriptional activators to these flavonoid biosynthetic genes resulting in gene activation and flavonoid accumulation in Arabidopsis plants.
- environmental stress,
- flavonoids biosynthesis,
- H2A.Z,
- MYB,
- transcription
Citation: Nguyen Hoai Nguyen. Histone variant H2A.Z and transcriptional activators may antagonistically regulate flavonoid biosynthesis[J]. AIMS Bioengineering, 2020, 7(1): 55-59. doi: 10.3934/bioeng.2020005

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Abstract

Flavonoid is an important group of plant secondary metabolites. The biosynthesis of this flavonoid group can be precisely regulated by many environmental factors. Currently, histone variants have been documented as important factors in the regulation of eukaryotic gene expression. H2A.Z histone variant has been found to function in numerous plant physiological programs including flavonoid biosynthesis. Moreover, the environmental changes have been shown to significantly influence the replacement between histone proteins and their variants leading to alterations in gene expression. Based on the recent studies, this mini-review is to provide an updated view on the functions of histone variant H2A.Z in the regulation of flavonoid biosynthetic gene expression. In addition, this also suggests a model in which the H2A.Z-containing nucleosomes can be evicted upon environmental stress conditions to facilitate the targeting of transcriptional activators to these flavonoid biosynthetic genes resulting in gene activation and flavonoid accumulation in Arabidopsis plants.

Acknowledgments

This work was supported by Ho Chi Minh City Open University.

Conflict of interest

The authors declare no conflict of interest.

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