To investigate the differences in sensitization status and patterns of inhaled allergens in children with allergic rhinitis, cough allergic asthma, and bronchial asthma, to avoid allergens, and to explore the relationship between the sensitization status and patterns of inhaled allergens in allergic rhinitis and asthma.
A retrospective evaluation was conducted on 1028 children with allergic rhinitis and asthma who underwent allergen specific IgE antibody testing at Xiamen University Affiliated Women's and Children's Hospital from 2022 to 2024. Based on basic medical information and clinical results, they were divided into allergic rhinitis group, cough allergic asthma group, and bronchial asthma group.
The most common inhaled allergen detected in this study was house dust mite, followed by house dust and mold. The positive frequency of most inhaled allergens in the bronchial asthma group was much higher than that in the cough allergic asthma group. The allergic rhinitis group had a higher frequency of sensitization to a single inhaled allergen, while the bronchial asthma group had a higher frequency of sensitization to quadruple sensitization. For single inhaled allergens, the bronchial asthma group had a higher frequency of strong positive sensitization. Patients with allergic rhinitis who were sensitive to house dust had a 2.763-fold increased risk of developing bronchial asthma. Patients with cough allergic asthma who were sensitive to house dust mites, cat hair, or house dust had a 3-fold increased risk of developing bronchial asthma. Multiple sensitization increases the likelihood of cough allergic asthma transforming into bronchial asthma.
The most common allergens detected in this study were house dust mites, house dust, and mold. Children with bronchial asthma were associated with sensitization to most inhaled allergens, especially strong positive sensitization and multiple sensitization.
Citation: Xiujuan Li, Jianmin Lin, Yan Li, Min Zhu, Minchuan Lin, Chenxi Li. Inhalation allergen sensitization patterns in children with allergic rhinitis and asthma[J]. AIMS Allergy and Immunology, 2024, 8(4): 254-264. doi: 10.3934/Allergy.2024015
To investigate the differences in sensitization status and patterns of inhaled allergens in children with allergic rhinitis, cough allergic asthma, and bronchial asthma, to avoid allergens, and to explore the relationship between the sensitization status and patterns of inhaled allergens in allergic rhinitis and asthma.
A retrospective evaluation was conducted on 1028 children with allergic rhinitis and asthma who underwent allergen specific IgE antibody testing at Xiamen University Affiliated Women's and Children's Hospital from 2022 to 2024. Based on basic medical information and clinical results, they were divided into allergic rhinitis group, cough allergic asthma group, and bronchial asthma group.
The most common inhaled allergen detected in this study was house dust mite, followed by house dust and mold. The positive frequency of most inhaled allergens in the bronchial asthma group was much higher than that in the cough allergic asthma group. The allergic rhinitis group had a higher frequency of sensitization to a single inhaled allergen, while the bronchial asthma group had a higher frequency of sensitization to quadruple sensitization. For single inhaled allergens, the bronchial asthma group had a higher frequency of strong positive sensitization. Patients with allergic rhinitis who were sensitive to house dust had a 2.763-fold increased risk of developing bronchial asthma. Patients with cough allergic asthma who were sensitive to house dust mites, cat hair, or house dust had a 3-fold increased risk of developing bronchial asthma. Multiple sensitization increases the likelihood of cough allergic asthma transforming into bronchial asthma.
The most common allergens detected in this study were house dust mites, house dust, and mold. Children with bronchial asthma were associated with sensitization to most inhaled allergens, especially strong positive sensitization and multiple sensitization.
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Xiujuan Li, Jianmin Lin, Yan Li, Min Zhu, Minchuan Lin, Chenxi Li. Inhalation allergen sensitization patterns in children with allergic rhinitis and asthma[J]. AIMS Allergy and Immunology, 2024, 8(4): 254-264. doi: 10.3934/Allergy.2024015
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