Advanced psoriasis treatment: Development and optimization of resorcinol-loaded nanoemulgel with lavender oil

Indu Singh; Riya Singh; Shikha Baghel Chauhan; Rajan Swami; Indu Singh; Riya Singh; Shikha Baghel Chauhan; Rajan Swami

doi:10.3934/Allergy.2024014

AIMS Allergy and Immunology

2024, Volume 8, Issue 4: 232-253. doi: 10.3934/Allergy.2024014

Previous Article Next Article

Research article

Advanced psoriasis treatment: Development and optimization of resorcinol-loaded nanoemulgel with lavender oil

1.
Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India
2.
School of Pharmacy, Chitkara University, Punjab, India

Received: 31 July 2024 Revised: 29 September 2024 Accepted: 04 October 2024 Published: 05 November 2024

Psoriasis, a long-term autoimmune illness, affects 2%–5% of people worldwide. Drugs from BCS class II that are commonly used to treat psoriasis include resorcinol, which presents burning feelings and itchiness as adverse effects. To minimize adverse effects and increase the effectiveness of treatment, a topical nanoemulgel was developed in the current research. A resorcinol-loaded nanoemulgel was developed using the nanoemulsion technique, and the Design Expert^® CCD method was used for optimization. Particle size (PS), zeta potential (ZP), and percentage of entrapment efficiency (EE%) served as the foundation for the optimization. The morphology, chemical interactions between excipients, crystallinity, and thermal behavior of the optimized resorcinol-loaded nanoemulgel were examined by TEM, FTIR, and XRD physicochemical studies. The resorcinol-loaded nanoemulgel was successfully loaded and characterized. For the in vitro release, the dialysis bag technique was employed. The ideal PS, PDI, and ZP values for the optimized resorcinol-loaded nanoemulgel were 31.32 ± 3.1 nm, 0.24 ± 0.005, and −10.6 ± 1.0 mV, respectively. The FTIR data revealed that no chemical interactions were observed between the components of resorcinol-loaded nanoemulgel, while the TEM results supported the spherical shape. The in vitro study confirmed a sustained release of resorcinol-loaded nanoemulgel.
- psoriasis,
- anti-inflammatory activity,
- nanoemultion,
- nanoemulgel,
- lavender oil
Citation: Indu Singh, Riya Singh, Shikha Baghel Chauhan, Rajan Swami. Advanced psoriasis treatment: Development and optimization of resorcinol-loaded nanoemulgel with lavender oil[J]. AIMS Allergy and Immunology, 2024, 8(4): 232-253. doi: 10.3934/Allergy.2024014

Related Papers:

Abstract

Psoriasis, a long-term autoimmune illness, affects 2%–5% of people worldwide. Drugs from BCS class II that are commonly used to treat psoriasis include resorcinol, which presents burning feelings and itchiness as adverse effects. To minimize adverse effects and increase the effectiveness of treatment, a topical nanoemulgel was developed in the current research. A resorcinol-loaded nanoemulgel was developed using the nanoemulsion technique, and the Design Expert^® CCD method was used for optimization. Particle size (PS), zeta potential (ZP), and percentage of entrapment efficiency (EE%) served as the foundation for the optimization. The morphology, chemical interactions between excipients, crystallinity, and thermal behavior of the optimized resorcinol-loaded nanoemulgel were examined by TEM, FTIR, and XRD physicochemical studies. The resorcinol-loaded nanoemulgel was successfully loaded and characterized. For the in vitro release, the dialysis bag technique was employed. The ideal PS, PDI, and ZP values for the optimized resorcinol-loaded nanoemulgel were 31.32 ± 3.1 nm, 0.24 ± 0.005, and −10.6 ± 1.0 mV, respectively. The FTIR data revealed that no chemical interactions were observed between the components of resorcinol-loaded nanoemulgel, while the TEM results supported the spherical shape. The in vitro study confirmed a sustained release of resorcinol-loaded nanoemulgel.

Acknowledgments

Authors are thankful to Amity Institute of Pharmacy, Amity University Noida for providing the technical support to complete this project.

Conflict of interest

The authors declare no conflict of interest.

Author contributions

Indu Singh; writing—original draft preparation, all authors; writing—review and editing. All authors have read and agreed to the published version of the manuscript.

References

[1]	Zaenglein AL, Pathy AL, Schlosser BJ, et al. (2016) Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol 74: 945-973.e33. https://doi.org/10.1016/j.jaad.2015.12.037
[2]	Cong TX, Hao D, Wen X, et al. (2019) From pathogenesis of acne vulgaris to anti-acne agents. Arch Dermatol Res 311: 337-349. https://doi.org/10.1007/s00403-019-01908-x
[3]	Keeling BH (2021) Practical immunodermatology. J Am Acad Dermatol 85: e123. https://doi.org/10.1016/j.jaad.2017.11.057
[4]	Lee HJ, Kim M (2022) Skin barrier function and the microbiome. Int J Mol Sci 23: 13071. https://doi.org/10.3390/ijms232113071
[5]	Rajagopalan M, Chatterjee M, De A, et al. (2021) Systemic management of psoriasis patients in Indian scenario: An expert consensus. Indian Dermatol Online J 12: 674. https://doi.org/10.4103/idoj.idoj_113_21
[6]	Dessinioti C, Katsambas A, Antoniou C (2014) Hidradenitis suppurrativa (acne inversa) as a systemic disease. Clin Dermatol 32: 397-408. https://doi.org/10.1016/j.clindermatol.2013.11.006
[7]	Shunatona B (2023) The benefits of lavender oil for your skin, according to derms. Byrdie . Available from: https://www.byrdie.com/lavender-oil-for-skin-4801192.
[8]	Scott AM, Stehlik P, Clark J, et al. (2019) Blue-light therapy for acne vulgaris: A systematic review and meta-analysis. Ann Fam Med 17: 545-553. https://doi.org/10.1370/afm.2445
[9]	Tan J, Bhate K (2015) A global perspective on the epidemiology of acne. Br J Dermatol 172: 3-12. https://doi.org/10.1111/bjd.13462
[10]	Tan J, Thiboutot D, Popp G, et al. (2019) Randomized phase 3 evaluation of trifarotene 50 µg/g cream treatment of moderate facial and truncal acne. J Am Acad Dermatol 80: 1691-1699. https://doi.org/10.1016/j.jaad.2019.02.044
[11]	Sabalingam NS, Siriwardhene NMA (2022) A review on emerging applications of emulgel as topical drug delivery system. World J Adv Res Rev 13: 452-463. https://doi.org/10.30574/wjarr.2022.13.1.0048
[12]	Khan BA, Ullah S, Khan M, et al. (2020) Formulation and evaluation of Ocimum basilicum-based emulgel for wound healing using animal model. Saudi Pharm J 28: 1842-1850. https://doi.org/10.1016/j.jsps.2020.11.011
[13]	Agarwal S, Krishnamurthy K (2024) Histology, Skin. Treasure Island (FL): StatPearls Publishing. Available from: https://pubmed.ncbi.nlm.nih.gov/30726010/
[14]	Özcelik S, Kulac I, Yazici M, et al. (2018) Distribution of childhood skin diseases according to age and gender, a single institution experience. Turk Pediatri Arsivi 53: 105-112. https://doi.org/10.5152/turkpediatriars.2018.6431
[15]	Heng AHS, Chew FT (2020) Systematic review of the epidemiology of acne vulgaris. Sci Rep 10. https://doi.org/10.1038/s41598-020-62715-3
[16]	Wang W, Wu C, Jin H (2019) Exosomes in chronic inflammatory skin diseases and skin tumors. Exp Dermatol 28: 213-218. https://doi.org/10.1111/exd.13857
[17]	Zouboulis C, Angres S (2020) Macrophage-activating lipopeptide-2 and corticotropin-releasing hormone stimulate the inflammatory signalling in human sebocytes through activation of stearoyl-CoA desaturase and fatty acid desaturase 2. J Eur Acad Dermatol Venereol 35: 493-501. https://doi.org/10.1111/jdv.17016
[18]	Katta R, Desai SP (2014) Diet and dermatology: The role of dietary intervention in skin disease. J Clin Aesthet Dermatol 7: 46-51. https://pubmed.ncbi.nlm.nih.gov/25053983/
[19]	Kim J (2005) Review of the innate immune response in acne vulgaris: Activation of Toll-Like receptor 2 in acne triggers inflammatory cytokine responses. Dermatology 211: 193-198. https://doi.org/10.1159/000087011
[20]	Kistowska M, Gehrke S, Jankovic D, et al. (2014) IL-1β Drives inflammatory responses to propionibacterium acnes in vitro and in vivo. J Invest Dermatol 134: 677-685. https://doi.org/10.1038/jid.2013.438
[21]	Shi VY, Leo M, Hassoun L, et al. (2015) Role of sebaceous glands in inflammatory dermatoses. J Am Acad Dermatol 73: 856-863. https://doi.org/10.1016/j.jaad.2015.08.015
[22]	Zeichner JA, Armstrong A (2016) The role of IL-17 in the pathogenesis and treatment of psoriasis. J Clin Aesthet Dermatol 9: S3-S6. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395242/
[23]	Yang Z, Zhang Y, Mosler EL, et al. (2020) Topical benzoyl peroxide for acne. Cochrane Database Syst Rev 3: CD011154. https://doi.org/10.1002/14651858.cd011154.pub2
[24]	Dogra S, Mahajan R (2016) Psoriasis: Epidemiology, clinical features, co-morbidities, and clinical scoring. Indian Dermatol Online J 7: 471. https://doi.org/10.4103/2229-5178.193906
[25]	Gottlieb AB, Ryan C, Murase JE (2019) Clinical considerations for the management of psoriasis in women. Inter J Women's Dermatol 5: 141-150. https://doi.org/10.1016/j.ijwd.2019.04.021
[26]	Korman N (2019) Management of psoriasis as a systemic disease: What is the evidence?. Br J Dermatol 182: 840-848. https://doi.org/10.1111/bjd.18245
[27]	Pradhan M, Yadav K, Singh D, et al. (2021) Topical delivery of fluocinolone acetonide integrated NLCs and salicylic acid enriched gel: A potential and synergistic approach in the management of psoriasis. J Drug Delivery Sci Technol 61: 102282. https://doi.org/10.1016/j.jddst.2020.102282
[28]	Khalid SA, Kumar BP, Abhinov T (2014) Formulation and in-vitro evaluation of Aceclofenac loaded topical Emulgel. Indian J Res Pharm Biotechnol 2: 1487-1489. Available from: https://ijrpb.com/issues/Volume%202_Issue%206/ijrpb%202(6)%2011%20khalid%201487-1489.pdf
[29]	Bansal M, Jamil S (2018) Micellar microparticles: A novel approach to topical drug delivery system. Inter J Appl Pharm 10: 1-5. https://doi.org/10.22159/ijap.2018v10i5.27506
[30]	Yousef Y, Alhajj M, Fakoya AO, et al. (2024) Anatomy, Skin (Integument), epidermis. Treasure Island (FL): StatPearls Publishing. Available from: https://pubmed.ncbi.nlm.nih.gov/29262154/
[31]	Wilson K, Bala A, Megha N, et al. (2023) Nanonutraceuticals and their applications. Nanotechnology and Drug Delivery. New York: Jenny Stanford Publishing 577-610. https://doi.org/10.1201/9781003430407-14
[32]	Semele R, Grewal S, Jeengar MK, et al. (2024) From traditional medicine to advanced therapeutics: The renaissance of phyto-nano interventions in psoriasis. Recent Adv Inflammation Allergy Drug Discovery 18: 27-42. https://doi.org/10.2174/0127722708265612231012080047
[33]	Jeengar MK, Rompicharla SVK, Shrivastava S, et al. (2016) Emu oil based Nanoemulgel for topical delivery of curcumin. Inter J Pharm 506: 222-236. https://doi.org/10.1016/j.ijpharm.2016.04.052

Reader Comments

Your name:*

Email:*
© 2024 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)