Colloidal stability of liposomes

Domenico Lombardo; Pietro Calandra; Maria Teresa Caccamo; Salvatore Magazù; Mikhail Alekseyevich Kiselev; Domenico Lombardo; Pietro Calandra; Maria Teresa Caccamo; Salvatore Magazù; Mikhail Alekseyevich Kiselev

doi:10.3934/matersci.2019.2.200

AIMS Materials Science

2019, Volume 6, Issue 2: 200-213. doi: 10.3934/matersci.2019.2.200

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Colloidal stability of liposomes

1.
Consiglio Nazionale delle Ricerche, Istituto per i Processi Chimico-Fisici, 98158 Messina, Italy
2.
Consiglio Nazionale delle Ricerche, Istituto Studio Materiali Nanostrutturati, 00015 Roma, Italy
3.
Dipartimento di Fisica e Scienze della Terra, Università di Messina, 98166 Messina, Italy
4.
Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, Moscow 141980, Russia

Received: 09 January 2019 Accepted: 11 March 2019 Published: 20 March 2019

In recent years, the development of novel approaches for the formation of lipid nano-formulations for efficient transport of drug molecules in living systems offers a wide range of biotechnology applications. However, despite the remarkable progress in recent methodologies of synthesis that provide a wide variety of solutions concerning the liposome surface functionalization and grafting with synthetic targeting ligands, the action of most liposomes is associated with a number of unwanted side effects diminishing their efficient use in nanomedicine and biotechnology. The major limitation in the use of such versatile and smart drug delivery systems is connected with their limited colloidal stability arising from the interaction with the complex environment and multiform interactions established within the specific biological media. Herein, we review the main interactions involved in liposomes used in drug delivery processes. We also analyze relevant strategies that aim at offering possible perspectives for the development of next-generation of liposomes nanocarriers that are able to overcome the critical issues during their action in complex biological media.
- liposomes,
- soft interaction,
- drug delivery,
- nanomedicine,
- nanoscience,
- nanotechnology
Citation: Domenico Lombardo, Pietro Calandra, Maria Teresa Caccamo, Salvatore Magazù, Mikhail Alekseyevich Kiselev. Colloidal stability of liposomes[J]. AIMS Materials Science, 2019, 6(2): 200-213. doi: 10.3934/matersci.2019.2.200

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Abstract

In recent years, the development of novel approaches for the formation of lipid nano-formulations for efficient transport of drug molecules in living systems offers a wide range of biotechnology applications. However, despite the remarkable progress in recent methodologies of synthesis that provide a wide variety of solutions concerning the liposome surface functionalization and grafting with synthetic targeting ligands, the action of most liposomes is associated with a number of unwanted side effects diminishing their efficient use in nanomedicine and biotechnology. The major limitation in the use of such versatile and smart drug delivery systems is connected with their limited colloidal stability arising from the interaction with the complex environment and multiform interactions established within the specific biological media. Herein, we review the main interactions involved in liposomes used in drug delivery processes. We also analyze relevant strategies that aim at offering possible perspectives for the development of next-generation of liposomes nanocarriers that are able to overcome the critical issues during their action in complex biological media.

References

[1]	Chen G, Roy I, Yang C, et al. (2016) Nanochemistry and nanomedicine for nanoparticle-based dagnostics and therapy. Chem Rev 116: 2826–2885. doi: 10.1021/acs.chemrev.5b00148
[2]	Ali I, Lone MN, Suhail M, et al. (2016) Advances in nanocarriers for anticancer drugs delivery. Curr Med Chem 23: 2159–2187. doi: 10.2174/0929867323666160405111152
[3]	Pasqua L, Leggio A, Sisci D, et al. (2016) Mesoporous silica nanoparticles in cancer therapy: relevance of the targeting function. Mini Rev Med Chem 16: 743–753. doi: 10.2174/1389557516666160321113620
[4]	Chow EKH, Ho D (2013) Cancer nanomedicine: from drug delivery to imaging. Sci Transl Med 5: 216rv4.
[5]	Lee BK, Yun YH, Park K (2015) Smart nanoparticles for drug delivery: boundaries and opportunities. Chem Eng Sci 125: 158–164. doi: 10.1016/j.ces.2014.06.042
[6]	Bozzuto G, Molinari A (2015) Liposomes as nanomedical devices. Int J Nanomed 10: 975–999.
[7]	Allen TM, Cullis PR (2013) Liposomal drug delivery systems: from concept to clinical applications. Adv Drug Deliver Rev 65: 36–48. doi: 10.1016/j.addr.2012.09.037
[8]	Bobo D, Robinson KJ, Islam J, et al. (2016) Nanoparticle-based medicines: a review of FDA-approved materials and clinical trials to date. Pharm Res 33: 2373–2387. doi: 10.1007/s11095-016-1958-5
[9]	Wilhelm S, Tavares AJ, Dai Q, et al. (2016) Analysis of nanoparticle delivery to tumours. Nat Rev Mater 1: 16014. doi: 10.1038/natrevmats.2016.14
[10]	Iwamoto T (2013) Clinical application of drug delivery systems in cancer chemotherapy: review of the efficacy and side effects of approved drugs. Biol Pharm Bull 36: 715–718. doi: 10.1248/bpb.b12-01102
[11]	Brand W, Noorlander CW, Giannakou C, et al. (2017) Nanomedicinal products: a survey on specific toxicity and side effects. Int J Nanomed 12: 6107–6129. doi: 10.2147/IJN.S139687
[12]	Janssen Products Expert Committee, DOXIL (doxorubicin HCl liposome injection), 2018. Available from: https://www.doxil.com.
[13]	Ishida T, Harashima H, Kiwada H (2001) Interactions of liposomes with cells in vitro and in vivo: opsonins and receptors. Curr Drug Metab 2: 397–409. doi: 10.2174/1389200013338306
[14]	Ishida T, Harashima H, Kiwada H, et al. (2002) Liposome clearance. Bioscience Rep 22: 197–224. doi: 10.1023/A:1020134521778
[15]	Lombardo D, Calandra P, Barreca D, et al. (2016) Soft interaction in liposome nanocarriers for therapeutic drug delivery. Nanomaterials 6: E125. doi: 10.3390/nano6070125
[16]	Dai Y, Xu C, Sun X, et al. (2017) Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment. Chem Soc Rev 46: 3830–3852. doi: 10.1039/C6CS00592F
[17]	Sackmann E (1995) Physical basis of self-organization and function of membranes: physics of vesicles, In: Lipowsky R, Sackmann E, Handbook of Biological Physics, Elsevier, 213–303.
[18]	Israelachvili J, Wennerström H (1996) Role of hydration and water structure in biological and colloidal interactions. Nature 379: 219–225. doi: 10.1038/379219a0
[19]	Franks F (1972) Water-a comprehensive treatise, New York, NY, USA: Plenum.
[20]	Magazù S, Migliardo F, Telling MT (2007) Study of the dynamical properties of water in disaccharide solutions. Eur Biophys J 36: 163–171. doi: 10.1007/s00249-006-0108-0
[21]	Degiorgio V, Corti M (1985) Physics of amphiphiles: micelles, vesicles and microemulsions, Amsterdam: North-Holland.
[22]	Tanford C (1980) The hydrophobic effect: formation of micelles and biological membranes, 2 Eds., New York: Wiley.
[23]	Parsegian VA (2006) Van der Waals forces: a handbook for biologists, chemists, engineers, and physicists, Cambridge University Press.
[24]	Hunter RJ (1986) Foundations of Colloid Science, Oxford University Press.
[25]	Cevc G (1993) Electrostatic characterization of liposomes. Chem Phys Lipids 64: 163–186. doi: 10.1016/0009-3084(93)90064-A
[26]	Dan N (2002) Effect of liposome charge and PEG polymer layer thickness on cell-liposome electrostatic interactions. BBA-Biomembranes 1564: 343–348. doi: 10.1016/S0005-2736(02)00468-6
[27]	Lombardo D (2014) Modeling dendrimers charge interaction in solution: relevance in biosystems. Biochem Res Int 2014: 837651.
[28]	Akpinar B, Fielding LA, Cunningham VJ, et al. (2016) Determining the effective density and stabilizer layer thickness of sterically stabilized nanoparticles. Macromolecules 49: 5160–5171. doi: 10.1021/acs.macromol.6b00987
[29]	Wang Z, Zhu W, Qiu Y, et al. (2016) Biological and environmental interactions of emerging two-dimensional nanomaterials. Chem Soc Rev 45: 1750–1780. doi: 10.1039/C5CS00914F
[30]	Moore TL, Rodriguez-Lorenzo L, Hirsch V, et al. (2015) Nanoparticle colloidal stability in cell culture media and impact on cellular interactions. Chem Soc Rev 44: 6287–6305. doi: 10.1039/C4CS00487F
[31]	Plessis JD, Ramachandran C, Weiner N (1996) The influence of lipid composition and lamellarity of liposomes on the physical stability of liposomes upon storage. Int J Pharm 127: 273–278. doi: 10.1016/0378-5173(95)04281-4
[32]	Ceh B, Lasic DD (1995) A rigorous theory of remote loading of drugs into liposomes. Langmuir 11: 3356–3368. doi: 10.1021/la00009a016
[33]	Geng S, Yang B, Wang G, et al. (2014) Two cholesterol derivative-based PEGylated liposomes as drug delivery system, study on pharmacokinetics and drug delivery to retina. Nanotechnology 25: 275103. doi: 10.1088/0957-4484/25/27/275103
[34]	Kiselev MA, Janich M, Hildebrand A, et al. (2013) Structural transition in aqueous lipid/bile salt [DPPC/NaDC] supramolecular aggregates: SANS and DLS study. Chem Phys 424: 93–99. doi: 10.1016/j.chemphys.2013.05.014
[35]	Kiselev MA, Lombardo D, Lesieur P, et al. (2008) Membrane self assembly in mixed DMPC/NaC systems by SANS. Chem Phys 345: 173–180. doi: 10.1016/j.chemphys.2007.09.034
[36]	Hernández-Caselles T, Villalaín J, Gómez-Fernández JC (1993) Influence of liposome charge and composition on their interaction with human blood serum proteins. Mol Cell Biochem 120: 119–126. doi: 10.1007/BF00926084
[37]	Narenji M, Talae MR, Moghimi HR (2017) Effect of Charge on Separation of Liposomes upon Stagnation. Iran J Pharm Res 16: 423–431.
[38]	Krasnici S, Werner A, Eichhorn ME, et al. (2003) Effect of the surface charge of liposomes on their uptake by angiogenic tumor vessels. Int J Cancer 105: 561–567. doi: 10.1002/ijc.11108
[39]	Jain NK, Nahar M (2010) PEGylated nanocarriers for systemic delivery. Methods Mol Biol 624: 221–234. doi: 10.1007/978-1-60761-609-2_15
[40]	Dan N (2014) Nanostructured lipid carriers: effect of solid phase fraction and distribution on the release of encapsulated materials. Langmuir 30: 13809–13814. doi: 10.1021/la5030197
[41]	Bourgaux C, Couvreur P (2014) Interactions of anticancer drugs with biomembranes: what can we learn from model membranes? J Control Release 190: 127–138. doi: 10.1016/j.jconrel.2014.05.012
[42]	Lombardo D, Calandra P, Magazù S, et al. (2018) Soft nanoparticles charge expression within lipid membranes: The case of amino terminated dendrimers in bilayers vesicles. Colloid Surface B 170: 609–616. doi: 10.1016/j.colsurfb.2018.06.031
[43]	Dan N (2016) Membrane-induced interactions between curvature-generating protein domains: the role of area perturbation. AIMS Biophys 4: 107–120.
[44]	Lombardo D, Calandra P, Bellocco E, et al. (2016) Effect of anionic and cationic polyamidoamine (PAMAM) dendrimers on a model lipid membrane. BBA-Biomembranes 1858: 2769–2777. doi: 10.1016/j.bbamem.2016.08.001
[45]	Katsaras J, Gutberlet T (2000) Lipid bilayers: Structure and Interactions, Springer Science & Business Media.
[46]	Wanderlingh U, D'Angelo G, Branca C (2014) Multi-component modeling of quasielastic neutron scattering from phospholipid membranes. J Chem Phys 140: 05B602.
[47]	Kiselev MA, Lombardo D (2017) Structural characterization in mixed lipid membrane systems by neutron and X-ray scattering. BBA-Gen Subjects 1861: 3700–3717. doi: 10.1016/j.bbagen.2016.04.022
[48]	Kiselev MA, Lesieur P, Kisselev AM, et al. (2001) A sucrose solutions application to the study of model biological membranes. Nucl Instrum Meth A 470: 409–416. doi: 10.1016/S0168-9002(01)01087-7
[49]	Blanco E, Shen H, Ferrari M (2015) Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat Biotechnol 33: 941–951. doi: 10.1038/nbt.3330
[50]	Pirollo KF, Chang EH (2008) Does a targeting ligand influence nanoparticle tumor localization or uptake? Trends Biotechnol 26: 552–558. doi: 10.1016/j.tibtech.2008.06.007
[51]	Bae YK, Park K (2011) Targeted drug delivery to tumors: myths, reality and possibility. J Control Release 153: 198–205. doi: 10.1016/j.jconrel.2011.06.001
[52]	Mura S, Nicolas J, Couvreur P (2013) Stimuli-responsive nanocarriers for drug delivery. Nat Mater 12: 991–1003. doi: 10.1038/nmat3776
[53]	Xing H, Hwang K, Lu Y (2016) Recent developments of liposomes as nanocarriers for theranostic applications. Theranostics 6: 1336–1352. doi: 10.7150/thno.15464
[54]	Lombardo D, Kiselev AM, Caccamo MT (2019) Smart nanoparticles for drug delivery application: development of versatile nanocarrier platforms in biotechnology and nanomedicine. J Nanomater 2019: 3702518.

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