The roles of genes in the bitter taste

Harem Othman Smail; Harem Othman Smail

doi:10.3934/genet.2019.4.88

AIMS Genetics

2019, Volume 6, Issue 4: 88-97. doi: 10.3934/genet.2019.4.88

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Review

The roles of genes in the bitter taste

Harem Othman Smail ^,

Department of Biology, Faculty of science and health, Koya University Koya KOY45, Kurdistan Region-F.R. Iraq

Received: 04 August 2019 Accepted: 07 December 2019 Published: 24 December 2019

The aims of this review were to understand the roles of bitter taste genes in humans. Some of the peoples have the capacity to taste some chemical substance such as phenylthiocarbamide (PTC) while others cant not based on the dietary hazards and food preferences. There are two alleles responsible to express these phenotypes which are homozygous recessive. In human TAS2R38 genes located on the chromosome number 7 and consist of different nucleotide polymorphism that related to detection of the phenotype of different chemical compounds such as 6-n-propylthiouracil (PROP) and phenylthiocarbamide bitterness and this Gene is the member of the TAS2R genes which are eleven pseudogenes and twenty that has roles in many biological processes.
There are many factors that affect the bitter taste such as food, age, sex, and different diseases. The mechanism of food bitter taste and genotype of TAS2R38 until know not well understood due to that the proof of relation between bitter taste sensitivity and food is harmful. there are many different diseases can impact the influence of taste such as neoplasm and lifestyle such as consumption of alcohol along with the use of medication, head trauma, upper tract infections. On the other hand, A relation between TAS2R38 genotype and meal preferences has been observed among children, however, no associations have been mentioned among older adults. Some previous research proved some vital points that show an association between type 1 of diabetes and phenylthiocarbamide (PTC) but other studies cannot demonstrate that. However, of other disease such as obesity is controversial but other studies reported to the relationship between them.
- TAS2R38,
- bitter taste receptors,
- phenylthiocarbamide (PTC),
- chromosomes 7,
- TAS2R,
- homozygotes,
- heterozygotes,
- polymorphisms
Citation: Harem Othman Smail. The roles of genes in the bitter taste[J]. AIMS Genetics, 2019, 6(4): 88-97. doi: 10.3934/genet.2019.4.88

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Abstract

The aims of this review were to understand the roles of bitter taste genes in humans. Some of the peoples have the capacity to taste some chemical substance such as phenylthiocarbamide (PTC) while others cant not based on the dietary hazards and food preferences. There are two alleles responsible to express these phenotypes which are homozygous recessive. In human TAS2R38 genes located on the chromosome number 7 and consist of different nucleotide polymorphism that related to detection of the phenotype of different chemical compounds such as 6-n-propylthiouracil (PROP) and phenylthiocarbamide bitterness and this Gene is the member of the TAS2R genes which are eleven pseudogenes and twenty that has roles in many biological processes.
There are many factors that affect the bitter taste such as food, age, sex, and different diseases. The mechanism of food bitter taste and genotype of TAS2R38 until know not well understood due to that the proof of relation between bitter taste sensitivity and food is harmful. there are many different diseases can impact the influence of taste such as neoplasm and lifestyle such as consumption of alcohol along with the use of medication, head trauma, upper tract infections. On the other hand, A relation between TAS2R38 genotype and meal preferences has been observed among children, however, no associations have been mentioned among older adults. Some previous research proved some vital points that show an association between type 1 of diabetes and phenylthiocarbamide (PTC) but other studies cannot demonstrate that. However, of other disease such as obesity is controversial but other studies reported to the relationship between them.

Conflict of interest

The authors declare no conflict of interest.

References

[1]	Reed DR, Tanaka T, McDaniel AH (2006) Diverse tastes: Genetics of sweet and bitter perception. Physiol Behav 88: 215–226. doi: 10.1016/j.physbeh.2006.05.033
[2]	Dobon B, Rossell C, Walsh S, et al. (2019) Is there adaptation in the human genome for taste perception and phase I biotransformation? BMC Evol Biol 19: 39. doi: 10.1186/s12862-019-1366-7
[3]	Cont G, Paviotti G, Montico M, et al. (2019) TAS2R38 bitter taste genotype is associated with complementary feeding behavior in infants. Genes Nutr 14: 13. doi: 10.1186/s12263-019-0640-z
[4]	Fu D, Riordan S, Kieran S, et al. (2019) Complex relationship between TAS2 receptor variations, bitterness perception, and alcohol consumption observed in a population of wine consumers. Food Funct 10: 1643–1652. doi: 10.1039/C8FO01578C
[5]	Martin LT, Nachtigal MW, Selman T, et al. (2019) Bitter taste receptors are expressed in human epithelial ovarian and prostate cancers cells and noscapine stimulation impacts cell survival. Mol Cell Biochem 454: 203–214. doi: 10.1007/s11010-018-3464-z
[6]	Shaw L, Mansfield C, Colquitt L, et al. (2018) Personalized expression of bitter 'taste' receptors in human skin. PloS One 13: e0205322. doi: 10.1371/journal.pone.0205322
[7]	Hwang LD, Gharahkhani P, Breslin PA, et al. (2018) Bivariate genome-wide association analysis strengthens the role of bitter receptor clusters on chromosomes 7 and 12 in human bitter taste. BMC Genomics 19: 678. doi: 10.1186/s12864-018-5058-2
[8]	oares , ilva , arc a-Estevez I, et al. (2018) Human bitter taste receptors are activated by different classes of polyphenols. J Agric Food Chem 66: 8814–8823. doi: 10.1021/acs.jafc.8b03569
[9]	Risso DS, Mezzavilla M, Pagani L, et al. (2016) Global diversity in the TAS2R38 bitter taste receptor: Revisiting a classic evolutionary PROPosal. Sci Rep 6: 25506. doi: 10.1038/srep25506
[10]	Fox AL (1932) The relationship between chemical constitution and taste. Proceedings of the National Academy of Sciences of the United States of America. Nat Acad Sci 18: 115–120.
[11]	Wooding S, Kim UK, Bamshad MJ, et al. (2004) Natural selection and molecular evolution in PTC, a bitter-taste receptor gene. Am J Hum Genet: 74: 637–646. doi: 10.1086/383092
[12]	Wooding S, Bufe B, Grassi C, et al. (2006) Independent evolution of bitter-taste sensitivity in humans and chimpanzees. Nature 440: 930. doi: 10.1038/nature04655
[13]	Zhong H, Shang S, Zhang H, et al. (2019) Characterization and phylogeny of bitter taste receptor genes (Tas2r) in Squamata. Genetica 6: 1–9. doi: 10.3934/genet.2019.1.1
[14]	Perna S, Riva A, Nicosanti G, et al. (2018) Association of the bitter taste receptor gene TAS2R38 (polymorphism RS713598) with sensory responsiveness, food preferences, biochemical parameters and body-composition markers. A cross-sectional study in Italy. Int J Food Sci Nutr 69: 245–252. doi: 10.1080/09637486.2017.1353954
[15]	Hayes JE, Bartoshuk LM, Kidd JR, et al. (2008) Supertasting and PROP bitterness depends on more than the TAS2R38 gene. Chem Senses 33: 255–265. doi: 10.1093/chemse/bjm084
[16]	Alimba CG, Adekoya KO, Oboh BO (2010) Prevalence and gene frequencies of phenylthiocarbamide (PTC) taste sensitivity, ABO and Rhesus factor (Rh) blood groups, and haemoglobin variants among a Nigerian population. Egypt J Med Hum Genet 11: 153–158. doi: 10.1016/j.ejmhg.2010.10.003
[17]	Risso DS, Kozlitina J, Sainz E, et al. (2016) Genetic variation in the TAS2R38 bitter taste receptor and smoking behaviors. PloS One 11: e0164157. doi: 10.1371/journal.pone.0164157
[18]	Calò C, Padiglia A, Zonza A, et al. (2011) Polymorphisms in TAS2R38 and the taste bud trophic factor, gustin gene co-operate in modulating PROP taste phenotype. Physiol Behav 104: 1065–1071. doi: 10.1016/j.physbeh.2011.06.013
[19]	Pronin AN, Xu H, Tang H, et al. (2007) Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin. Current Biol 17: 1403–1408. doi: 10.1016/j.cub.2007.07.046
[20]	Duffy VB, Davidson AC, Kidd JR, et al. (2004) Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake. Alcohol: Clin Exp Res 28: 1629–1637. doi: 10.1097/01.ALC.0000145789.55183.D4
[21]	Drayna D, Coon H, Kim UK, et al. (2003) Genetic analysis of a complex trait in the Utah Genetic Reference Project: A major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p. Hum Genet 112: 567–572. doi: 10.1007/s00439-003-0911-y
[22]	Mennella JA, Pepino MY, Duke FF, et al. (2010) Age modifies the genotype-phenotype relationship for the bitter receptor TAS2R38. BMC Genet 11: 60.
[23]	Puputti S, Aisala H, Hoppu U, et al. (2019) Factors explaining individual differences in taste sensitivity and taste modality recognition among Finnish adults. J Sens Stud 2019: e12506.
[24]	Cavallo C, Cicia G, Del Giudice T, et al. (2019) Consumers' perceptions and preferences for bitterness in vegetable foods: The case of extra-virgin olive oil and brassicaceae-A narrative review. Nutrients 11: 1164. doi: 10.3390/nu11051164
[25]	El-Sohemy A, Stewart L, Khataan L, et al. (2007) Nutrigenomics of taste–impact on food preferences and food production. Lit Rev 60: 176–182.
[26]	Suzuki N, Sugawara T, Matsui A, et al. (2010) Identification of non-taster Japanese macaques for a specific bitter taste. Primates 51: 285–289. doi: 10.1007/s10329-010-0209-3
[27]	Precone V, Beccari T, et al. (2019) Taste, olfactory and texture related genes and food choices: Implications on health status. Eur Rev Med Pharmacol Sci 23: 1305–1321.
[28]	Aldaz KJ, Flores SO, Ortiz RM, et al. (2019) Influence of Phenylthiocarbamide taster status on sensory perceptions of fruits, vegetables nuts. FASEB J 33: 590–596.
[29]	Mennella JA, Pepino MY, Duke FF, et al. (2010) Psychophysical dissection of genotype effects on human bitter perception. Chem Senses 36: 161–167.
[30]	Igbeneghu C, Olisekodiaka JM, Onuegbu JA, et al. (2019) Phenylthiocarbamide taste perception among patients with type 2 diabetes mellitus. Asian J Med Health 6:1–5.
[31]	Duffy VB, Glennon SG, Larsen BA, et al. (2019) Heightened olfactory dysfunction and oral irritation among chronic smokers and heightened propylthiouracil (PROP) bitterness among menthol smokers. Physiol Behav 201: 111–122. doi: 10.1016/j.physbeh.2018.12.017
[32]	Lambert JD, VanDusen SR, Cockroft JE, et al. (2018) Bitter taste sensitivity, food intake, and risk of malignant cancer in the UK Women's Cohort tudy. Eur J Nutr 58: 2111–2121.
[33]	Navarro-Allende A, Khataan N, El-Sohemy A (2008) Impact of genetic and environmental determinants of taste with food preferences in older adults. J Nutr Elderly 27: 267–276. doi: 10.1080/01639360802261920
[34]	Merritt RB, Bierwert LA, Slatko B, et al. (2008) Tasting phenylthiocarbamide (PTC): A new integrative genetics lab with an old flavor. Am Biol Teach 70.
[35]	Besnard P, Passilly-Degrace P, Khan NA (2015) Taste of fat: A sixth taste modality? Physiol Rev 96: 151–176.
[36]	Melis M, Tomassini Barbarossa I (2017) Taste perception of sweet, sour, salty, bitter, and umami and changes due to l-Arginine supplementation, as a function of genetic ability to taste 6-n-Propylthiouracil. Nutrients 9: 541. doi: 10.3390/nu9060541
[37]	Risso D, Sainz E, Morini G, et al. (2018) Taste perception of Antidesma bunius fruit and its relationships to bitter taste receptor gene haplotypes. Chem Senses 43: 463–468. doi: 10.1093/chemse/bjy037
[38]	Rahim HM, Majeed RK, Rostam NA (2018) Prevalence, biochemical, and genetic analysis of mutated gene related to bitter taste perception for phenylthiocarbamide in Sulaymaniyah Province, Iraq. Med J Babylon 15: 201.
[39]	Mohaus HA, Ayied AY (2018) A study of the relationship between the taste sensitivity of Phenylthiocarbamide (PTC) and blood pressure (Random Sample from the Students of Qurna College/Basrah-Iraq). J Biosci Med 6: 1–12.
[40]	Driscoll KA, Perez M, Cukrowicz KC, et al. (2006) Associations of phenylthiocarbamide tasting to alcohol problems and family history of alcoholism differ by gender. Psychiatry Res 143: 21–27. doi: 10.1016/j.psychres.2005.07.029
[41]	Lim J, Urban L, Green BG (2008) Measures of individual differences in taste and creaminess perception. Chem Senses 33: 493–501. doi: 10.1093/chemse/bjn016
[42]	Lee RJ, Cohen NA (2014) Bitter and sweet taste receptors in the respiratory epithelium in health and disease. J Mol Med 92: 1235–1244. doi: 10.1007/s00109-014-1222-6
[43]	Moberg PJ, Balderston CC, Rick JH, et al. (2007) Phenylthiocarbamide (PTC) perception in Parkinson disease. Cognit Behav Neurol 20: 145–148. doi: 10.1097/WNN.0b013e31812570c3
[44]	Ammann J, Hartmann C, Siegrist M (2019) A bitter taste in the mouth: The role of 6-n-propylthiouracil taster status and sex in food disgust sensitivity. Physiol Behav 204: 219–223. doi: 10.1016/j.physbeh.2019.02.036
[45]	Adappa ND, Farquhar D, Palmer JN, et al. (2016) TAS2R38 genotype predicts surgical outcome in nonpolypoid chronic rhinosinusitis. Int Forum Allergy Rhinol 6: 25–33. doi: 10.1002/alr.21666
[46]	Keller KL, Olsen A, Cravener TL, et al. (2014) Bitter taste phenotype and body weight predict children's selection of sweet and savory foods at a palatable test-meal. Appetite 77: 115–123. doi: 10.1016/j.appet.2014.02.019
[47]	Keller KL, Reid A, MacDougall MC, et al. (2010) Sex differences in the effects of inherited bitter thiourea sensitivity on body weight in 4–6‐Year‐Old Children. Obesity 18: 1194–1200. doi: 10.1038/oby.2009.306
[48]	Wang Q, Liszt KI, Deloose E, et al. (2019) Obesity alters adrenergic and chemosensory signaling pathways that regulate ghrelin secretion in the human gut. FASEB J 33: fj.201801661RR.
[49]	Turner A, Veysey M, Keely S, et al. (2018) Interactions between bitter taste, diet and dysbiosis: Consequences for appetite and obesity. Nutrients 10: 1336. doi: 10.3390/nu10101336
[50]	Qin C, Qin Z, Zhao D, et al. (2019) A bioinspired in vitro bioelectronic tongue with human T2R38 receptor for high-specificity detection of NC=S-containing compounds. Talanta 199: 131–139. doi: 10.1016/j.talanta.2019.02.021
[51]	Brown A, England R, St-John J, et al. (2013) The liking and preferences of people with thoracic cancer for oral nutritional supplement drinks. e-SPEN J 8: e55–e58. doi: 10.1016/j.clnme.2012.12.005
[52]	Uí Dhuibhir P, Collura N, Walsh D (2019) Complete oral nutritional supplements: Dietitian preferences and clinical practice. J Diet Suppl 16: 40–50. doi: 10.1080/19390211.2018.1428260

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