Manuscript Topics

It well known that ionizing radiation, when impinging on living targets, can produce a variety of effects at different levels, starting from DNA and chromosome damage down to cell death and damage at the level of tissues/organs, or even whole organism. Therefore, several exposure scenarios (e.g., occupational exposure, radon, space radiation…) raise radiation protection issues. On the other side, ionizing radiation is widely used in medicine, both as a diagnostic tool and as a therapeutic agent.

It is therefore mandatory for the scientific community to continuously improve the knowledge of the mechanisms underlying the induction of radiation effects in biological targets, and to apply the acquired information to optimize the use of radiation in medicine, as well as the radiation protection strategies. These investigations can be carried out both experimentally, by means of in vitro and/or in vivo studies, and theoretically, by biophysical models and simulation codes.

More specifically, not all aspects of these issues have been fully elucidated: for instance, although the DNA is widely recognized as the main radiation target, the molecular characteristics of the critical DNA damage type(s) that can lead to cell conversion to malignancy or cell death are still unclear; moreover, further investigation is needed on the role played by other targets, which may be involved in low-dose phenomena including the so-called “bystander effects”. Among the many possible medical applications, different aspects of ion therapy should be further addressed, including a more and more accurate RBE evaluation and the use of other ion types such as He- and O-ions.

This Special Issue is open to researchers working in the different fields of ionizing radiation, both experimentally and theoretically. We therefore welcome papers on the different types of DNA/chromosome/cell damage, as well as the possible implications for radiation protection and for the medical use of radiation. Papers on radiation detection and dosimetry are also welcome. Furthermore, papers on the potential effects of ionizing radiation on all biological systems are welcome.

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