Structure and function of histone acetyltransferase MOF

Qiao Yi Chen; Max Costa; Hong Sun; Qiao Yi Chen; Max Costa; Hong Sun

doi:10.3934/biophy.2015.4.555

AIMS Biophysics

2015, Volume 2, Issue 4: 555-569. doi: 10.3934/biophy.2015.4.555

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Review Special Issues

Structure and function of histone acetyltransferase MOF

Department of Environmental Medicine, NYU School of Medicine, Tuxedo, NY 10987, USA

Received: 08 August 2015 Accepted: 08 October 2015 Published: 19 October 2015

MOF was first identified in Drosophila melanogaster as an important component of the dosage compensation complex. As a member of MYST family of histone acetyltransferase, MOF specifically deposits the acetyl groups to histone H4 lysine 16. Throughout evolution, MOF and its mammalian ortholog have retained highly conserved substrate specificity and similar enzymatic activities. MOF plays important roles in dosage compensation, ESC self-renewal, DNA damage and repair, cell survival, and gene expression regulation. Dysregulation of MOF has been implicated in tumor formation and progression of many types of human cancers. This review will discuss the structure and activity of mammalian hMOF as well as its function in H4K16 acetylation, DNA damage response, stem cell pluripotency, and carcinogenesis.
- MOF,
- H4K16,
- histone acetylation,
- MSL,
- NSL
Citation: Qiao Yi Chen, Max Costa, Hong Sun. Structure and function of histone acetyltransferase MOF[J]. AIMS Biophysics, 2015, 2(4): 555-569. doi: 10.3934/biophy.2015.4.555

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Abstract

MOF was first identified in Drosophila melanogaster as an important component of the dosage compensation complex. As a member of MYST family of histone acetyltransferase, MOF specifically deposits the acetyl groups to histone H4 lysine 16. Throughout evolution, MOF and its mammalian ortholog have retained highly conserved substrate specificity and similar enzymatic activities. MOF plays important roles in dosage compensation, ESC self-renewal, DNA damage and repair, cell survival, and gene expression regulation. Dysregulation of MOF has been implicated in tumor formation and progression of many types of human cancers. This review will discuss the structure and activity of mammalian hMOF as well as its function in H4K16 acetylation, DNA damage response, stem cell pluripotency, and carcinogenesis.

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