Membrane-induced interactions between curvature-generating protein domains: the role of area perturbation

Nily Dan; Nily Dan

doi:10.3934/biophy.2017.1.107

AIMS Biophysics

2017, Volume 4, Issue 1: 107-120. doi: 10.3934/biophy.2017.1.107

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Research article

Membrane-induced interactions between curvature-generating protein domains: the role of area perturbation

Nily Dan ^,

Department of Chemical and Biological Engineering, Drexel University, 3101 Chestnut St, Philadelphia PA 19104, USA

Received: 07 November 2016 Accepted: 24 January 2017 Published: 06 February 2017

Membrane deformation by asymmetric crescent-shaped proteins such as BAR-domains is calculated, using a mean field model that accounts for both bending and area stretch deformations. The penalties associated with membrane bending and area perturbation lead to moderately long-ranged (order 10 nm), non-monotonic, membrane-induced interactions between proteins that may prevent the formation of closely packed aggregates. As a result, BAR-domain proteins may favor the formation of an ordered array with a specific separation between domains whose spacing is set by the ratio between the bending and area stretch moduli.
- BAR domain,
- Amphiphysin,
- membrane perturbation,
- Helfrich model
Citation: Nily Dan. Membrane-induced interactions between curvature-generating protein domains: the role of area perturbation[J]. AIMS Biophysics, 2017, 4(1): 107-120. doi: 10.3934/biophy.2017.1.107

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Abstract

Membrane deformation by asymmetric crescent-shaped proteins such as BAR-domains is calculated, using a mean field model that accounts for both bending and area stretch deformations. The penalties associated with membrane bending and area perturbation lead to moderately long-ranged (order 10 nm), non-monotonic, membrane-induced interactions between proteins that may prevent the formation of closely packed aggregates. As a result, BAR-domain proteins may favor the formation of an ordered array with a specific separation between domains whose spacing is set by the ratio between the bending and area stretch moduli.

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