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AIMS Molecular Science

2015, Volume 2, Issue 3: 259-293. doi: 10.3934/molsci.2015.3.259
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The disruption of proteostasis in neurodegenerative disorders

  • 1.
    Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal;
  • 2.
    ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimarães, Portugal
  • Received: 01 April 2015 Accepted: 01 June 2015 Published: 07 June 2015

  • Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.

    Citation: Ana Jalles, Patrícia Maciel. The disruption of proteostasis in neurodegenerative disorders[J]. AIMS Molecular Science, 2015, 2(3): 259-293. doi: 10.3934/molsci.2015.3.259

    Related Papers:

  • Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.


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