Search Advanced

Networks and Heterogeneous Media

2013, Volume 8, Issue 1: 65-78. doi: 10.3934/nhm.2013.8.65
Previous Article Next Article

Growth regulation and the insulin signaling pathway

  • 1.
    Department of Mathematics, Michigan State University, East Lansing, MI 48824
  • 2.
    Department of Zoology, Michigan State University, East Lansing, MI 48824
  • Received: 01 April 2012 Revised: 01 January 2013

  • Primary: 92-08, 92C42, 92C40; Secondary: 92C37, 92C30.

  • The insulin signaling pathway propagates a signal from receptors in the cell membrane to the nucleus via numerous molecules some of which are transported through the cell in a partially stochastic way. These different molecular species interact and eventually regulate the activity of the transcription factor FOXO, which is partly responsible for inhibiting the growth of organs. It is postulated that FOXO partially governs the plasticity of organ growth with respect to insulin signalling, thereby preserving the full function of essential organs at the expense of growth of less crucial ones during starvation conditions. We present a mathematical model of this reacting and directionally-diffusing network of molecules and examine the predictions resulting from simulations.

    Citation: Peter W. Bates, Yu Liang, Alexander W. Shingleton. Growth regulation and the insulin signaling pathway[J]. Networks and Heterogeneous Media, 2013, 8(1): 65-78. doi: 10.3934/nhm.2013.8.65

    Related Papers:

    [1] Peter W. Bates, Yu Liang, Alexander W. Shingleton . Growth regulation and the insulin signaling pathway. Networks and Heterogeneous Media, 2013, 8(1): 65-78. doi: 10.3934/nhm.2013.8.65
    [2] Russell Betteridge, Markus R. Owen, H.M. Byrne, Tomás Alarcón, Philip K. Maini . The impact of cell crowding and active cell movement on vascular tumour growth. Networks and Heterogeneous Media, 2006, 1(4): 515-535. doi: 10.3934/nhm.2006.1.515
    [3] Didier Georges . Infinite-dimensional nonlinear predictive control design for open-channel hydraulic systems. Networks and Heterogeneous Media, 2009, 4(2): 267-285. doi: 10.3934/nhm.2009.4.267
    [4] Mirela Domijan, Markus Kirkilionis . Graph theory and qualitative analysis of reaction networks. Networks and Heterogeneous Media, 2008, 3(2): 295-322. doi: 10.3934/nhm.2008.3.295
    [5] Marco Scianna, Luca Munaron . Multiscale model of tumor-derived capillary-like network formation. Networks and Heterogeneous Media, 2011, 6(4): 597-624. doi: 10.3934/nhm.2011.6.597
    [6] Yacine Chitour, Frédéric Grognard, Georges Bastin . Equilibria and stability analysis of a branched metabolic network with feedback inhibition. Networks and Heterogeneous Media, 2006, 1(1): 219-239. doi: 10.3934/nhm.2006.1.219
    [7] Yaru Xie, Genqi Xu . The exponential decay rate of generic tree of 1-d wave equations with boundary feedback controls. Networks and Heterogeneous Media, 2016, 11(3): 527-543. doi: 10.3934/nhm.2016008
    [8] Achilles Beros, Monique Chyba, Oleksandr Markovichenko . Controlled cellular automata. Networks and Heterogeneous Media, 2019, 14(1): 1-22. doi: 10.3934/nhm.2019001
    [9] Gildas Besançon, Didier Georges, Zohra Benayache . Towards nonlinear delay-based control for convection-like distributed systems: The example of water flow control in open channel systems. Networks and Heterogeneous Media, 2009, 4(2): 211-221. doi: 10.3934/nhm.2009.4.211
    [10] Mogtaba Mohammed, Mamadou Sango . Homogenization of nonlinear hyperbolic stochastic partial differential equations with nonlinear damping and forcing. Networks and Heterogeneous Media, 2019, 14(2): 341-369. doi: 10.3934/nhm.2019014
  • The insulin signaling pathway propagates a signal from receptors in the cell membrane to the nucleus via numerous molecules some of which are transported through the cell in a partially stochastic way. These different molecular species interact and eventually regulate the activity of the transcription factor FOXO, which is partly responsible for inhibiting the growth of organs. It is postulated that FOXO partially governs the plasticity of organ growth with respect to insulin signalling, thereby preserving the full function of essential organs at the expense of growth of less crucial ones during starvation conditions. We present a mathematical model of this reacting and directionally-diffusing network of molecules and examine the predictions resulting from simulations.


    [1] Robert P. Erickson, Zhiyuan Jia, Steven P. Gross and Clare C. Yu, How molecular motors are arranged on a cargo is important for vesicular transport, PLoS Comput Biol., 7 (2011), 1-22.
    [2] Ahmed Essaghir, Nicolas Dif, Catherine Y. Marbehant, Paul J. Coffer and Jean-Baptiste Demoulin, The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors, J. Biol. Chem., 284 (2009), 10334-10342. doi: 10.1074/jbc.M808848200
    [3] Geert J. Kops, Nancy D. de Ruiter, Alida M. Vries-Smits, David R. Powell, Johannes L. Bos and Boudewijn M. Burgering, Direct control of the Forkhead transcription factor AFX by protein kinase B, Nature, 398 (1999), 630-634.
    [4] Hitomi Matsuzaki, Hiroaki Daitoku, Mitsutoki Hatta, Keiji Tanaka and Akiyoshi Fukamizu, Insulin- induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation, Proc. Natl. Acad. Sci. U S A, 100 (2003), 11285-11290. doi: 10.1073/pnas.1934283100
    [5] Oscar Puig and Robert Tjian, Transcriptional feedback control of insulin receptor by dFOXO/FOXO1, Genes & Dev., 19 (2005), 2435-2446. doi: 10.1101/gad.1340505
    [6] Michael J. Quon and L. A. Campfield, A mathematical model and computer simulation study of insulin receptor regulation, J. Theor. Biol., 150 (1991), 59-72. doi: 10.1016/S0022-5193(05)80475-8
    [7] Michael J. Quon and L. A. Campfield, A mathematical model and computer simulation study of insulin-sensitive glucose transporter regulation, J. Theor. Biol., 150 (1991), 93-107. doi: 10.1016/S0022-5193(05)80477-1
    [8] Jaime Resino and Antonio García-Bellido, Drosophila genetic variants that change cell size and rate of proliferation affect cell communication and hence patterning, Mechanisms of Development, 121 (2004), 351-364. doi: 10.1016/j.mod.2004.02.007
    [9] Ahmad R. Sedaghat, Arthur Sherman and Michael J. Quon, A mathematical model of metabolic insulin signaling pathways, Am. J. Physiol. Endocrinol. Metab., 283 (2002), 84-101.
    [10] Alexander W. Shingleton, The regulation of organ size in drosophila, Organogenesis, 6 (2010), 1-13.
    [11] Graham R. Smith and Daryl P. Shanley, Modelling the response of FOXO transcription factor to multiple post-translational modifications made by ageing-related signalling pathways, PLoS ONE, 5 (2010), 1-18. doi: 10.1371/journal.pone.0011092
    [12] Huiyuan Tang, Martha S. B. Smith-Caldas, Michael V. Driscoll, Samy Salhadar and Alexander W. Shingleton, FOXO regulates organ-specific phenotypic plasticity in drosophila, PLoS Genet., 7 (2011), 1-12. doi: 10.1371/journal.pgen.1002373
    [13] Lars P. Van Der Heide, Marco F. M. Hoekman and Marten P. Smidt, The ins and outs of FoxO shuttling: Mechanism of FoxO translocation and transcriptional regulation, Biochem. J., 380 (2004), 297-309.

  • This article has been cited by:

    1. Catheryn W. Gray, Adelle C.F. Coster, A receptor state space model of the insulin signalling system in glucose transport, 2015, 1477-8599, dqv003, 10.1093/imammb/dqv003
    2. Catheryn W. Gray, Adelle C. F. Coster, Crosstalk in transition: the translocation of Akt, 2019, 78, 0303-6812, 919, 10.1007/s00285-018-1297-8
    3. Catheryn W. Gray, Adelle C.F. Coster, From insulin to Akt: Time delays and dominant processes, 2020, 507, 00225193, 110454, 10.1016/j.jtbi.2020.110454
    4. Catheryn W. Gray, Adelle C.F. Coster, The Akt switch model: Is location sufficient?, 2016, 398, 00225193, 103, 10.1016/j.jtbi.2016.03.005
    5. Lizzette D. Cambron, George D. Yocum, Kathleen M. Yeater, Kendra J. Greenlee, Overwintering conditions impact insulin pathway gene expression in diapausing Megachile rotundata, 2021, 256, 10956433, 110937, 10.1016/j.cbpa.2021.110937
    6. Catheryn W. Gray, Adelle C.F. Coster, Deciphering Akt activation: Insights from a mean-field model, 2025, 00255564, 109434, 10.1016/j.mbs.2025.109434
  • Reader Comments
  • © 2013 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Networks and Heterogeneous Media
1.2 1.8

Metrics

Article views(3924) PDF downloads(74) Cited by(6)

Preview PDF
Download XML
Export Citation
Article outline
Abstract
References

Other Articles By Authors

Related pages

Tools

Copyright © AIMS Press

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return

Catalog