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Mathematical Biosciences and Engineering

2004, Volume 1, Issue 1: 1-13. doi: 10.3934/mbe.2004.1.1
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Critical role of nosocomial transmission in the Toronto SARS outbreak

  • 1.
    Department of Mathematics, Vanderbilt University, 1326 Stevenson Center, Nashville, TN 37240
  • 2.
    Department of Medicine, New York University School of Medicine, OBV A606, 550 First Avenue, New York, NY 10016
  • 3.
    Laboratory for Industrial and Applied Mathematics, Department of Mathematics and Statistics, York University, 4700 Keele Street, Toronto, ON, M3J 1P3
  • 4.
    Central East Health Information Partnership, Box 159, 4950 Yonge Street, Suite 610, Toronto, ON M2N 6K1
  • Received: 01 December 2003 Accepted: 29 June 2018 Published: 01 March 2004

  • MSC : 92D30.

  • We develop a compartmental mathematical model to address the role of hospitals in severe acute respiratory syndrome (SARS) transmission dynamics, which partially explains the heterogeneity of the epidemic. Comparison of the e ffects of two major policies, strict hospital infection control procedures and community-wide quarantine measures, implemented in Toronto two weeks into the initial outbreak, shows that their combination is the key to short-term containment and that quarantine is the key to long-term containment.

    Citation: Glenn Webb, Martin J. Blaser, Huaiping Zhu, Sten Ardal, Jianhong Wu. Critical role of nosocomial transmission in the Toronto SARS outbreak[J]. Mathematical Biosciences and Engineering, 2004, 1(1): 1-13. doi: 10.3934/mbe.2004.1.1

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  • We develop a compartmental mathematical model to address the role of hospitals in severe acute respiratory syndrome (SARS) transmission dynamics, which partially explains the heterogeneity of the epidemic. Comparison of the e ffects of two major policies, strict hospital infection control procedures and community-wide quarantine measures, implemented in Toronto two weeks into the initial outbreak, shows that their combination is the key to short-term containment and that quarantine is the key to long-term containment.


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