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AIMS Genetics

2017, Volume 4, Issue 1: 32-46. doi: 10.3934/genet.2017.1.32
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A search for the common ground between Tic; Obsessive-compulsive and Autism Spectrum Disorders: part I, Tic disorders

  • 1.
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC, USA
  • 2.
    Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
  • 3.
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
  • Received: 30 November 2016 Accepted: 09 February 2017 Published: 21 February 2017

  • This article is the first of four articles designed to explore the complex interrelationship between Autism Spectrum Disorders (ASD); Obsessive compulsive and Related Disorders (OCRD) and Tic Disorders/Tourette’s Syndrome (TD/TS). We begin with an overview TD/TS and follow-up with reviews of OCRD and ASD. The final article in this series represents a synthesis of the neurobiological and genetic markers shared by patients presenting with all three syndromes. The goal is to describe the complex endophenotype of these patients in an effort to better define gene markers that underlie these heterogeneous clinical syndromes. Tic disorders (TD) are a collection of hyperkinetic movements that begin in early childhood. Tics are transient for most affected preschool children but a subgroup development persistent movements or progress to develop Tourette Syndrome (TS). TDs as a group display high heritability rates but definitive gene markers still elude us. The difficulty defining genetic markers is in large part due to the diverse neurodevelopmental trajectory, changing topography and typology, development of a broad spectrum of neurocognitive and behavioral complications, and a mixed pattern of psychiatric comorbidities.

    Citation: Jarrett Barnhill, James Bedford, James Crowley, Takahiro Soda. A search for the common ground between Tic; Obsessive-compulsive and Autism Spectrum Disorders: part I, Tic disorders[J]. AIMS Genetics, 2017, 4(1): 32-46. doi: 10.3934/genet.2017.1.32

    Related Papers:

  • This article is the first of four articles designed to explore the complex interrelationship between Autism Spectrum Disorders (ASD); Obsessive compulsive and Related Disorders (OCRD) and Tic Disorders/Tourette’s Syndrome (TD/TS). We begin with an overview TD/TS and follow-up with reviews of OCRD and ASD. The final article in this series represents a synthesis of the neurobiological and genetic markers shared by patients presenting with all three syndromes. The goal is to describe the complex endophenotype of these patients in an effort to better define gene markers that underlie these heterogeneous clinical syndromes. Tic disorders (TD) are a collection of hyperkinetic movements that begin in early childhood. Tics are transient for most affected preschool children but a subgroup development persistent movements or progress to develop Tourette Syndrome (TS). TDs as a group display high heritability rates but definitive gene markers still elude us. The difficulty defining genetic markers is in large part due to the diverse neurodevelopmental trajectory, changing topography and typology, development of a broad spectrum of neurocognitive and behavioral complications, and a mixed pattern of psychiatric comorbidities.


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    [1] Pauls DL (2006) A genome-wide scan and fine mapping in Tourette syndrome families. Adv Neurol 99: 130-135.
    [2] Neal M, Cavanna AE (2013) "Not just right experiences" in patients with Tourette syndrome: complex motor tics or compulsions? Psychiatry Res 210: 559-563. doi: 10.1016/j.psychres.2013.06.033
    [3] Robertson MM (1992) Self-injurious behavior and Tourette syndrome. Adv Neurol 58: 105-114.
    [4] Mejia NI, Jankovic J (2005) Secondary tics and tourettism. Rev Bras Psiquiatr 27: 11-17. doi: 10.1590/S1516-44462005000100006
    [5] Kwok H, Cheung PW (2007) Co-morbidity of psychiatric disorder and medical illness in people with intellectual disabilities. Curr Opin Psychiatry 20: 443-449. doi: 10.1097/YCO.0b013e3282ab9941
    [6] Cooper NS, Feder A, Southwick SM, et al. (2007) Resilience and Vulnerability to Trauma Psychobiological Mechanisms. Adolescent psychopathology and the developing brain: integrating brain and prevention science: 347-372.
    [7] Piven J, O'Leary D (1997) Neuroimaging in autism. Child and Adolescent Psychiatric Clinics of North America 6: 305-323.
    [8] Paschou P (2013) The genetic basis of Gilles de la Tourette Syndrome. Neurosci Biobehav Rev 37: 1026-1039. doi: 10.1016/j.neubiorev.2013.01.016
    [9] American Psychiatric Association., American Psychiatric Association. DSM-5 Task Force. (2013) Diagnostic and statistical manual of mental disorders : DSM-5. Washington, D.C.: American Psychiatric Association. xliv, 947 p. p.
    [10] Barnhill LJ, Hurley AD (2008) Movement disorders: Things that do go bump in the night. Mental Health Aspects of Developmental Disabilities 11: 5.
    [11] Shaw ZA, Coffey BJ (2014) Tics and Tourette syndrome. Psychiatr Clin North Am 37: 269-286. doi: 10.1016/j.psc.2014.05.001
    [12] Robertson MM (2000) Tourette syndrome, associated conditions and the complexities of treatment. Brain 123: 425-462. doi: 10.1093/brain/123.3.425
    [13] Jankovic J (2007) Tics and Tourette's Disorders in Children. In: Jankovic J, Tolosa E, editors. Parkinson's disease and movement disorders. 5th ed. Philadelphia: Lippincott Williams & Wilkins. pp. 356-375.
    [14] Singer H (2007) Movement disorders in Children In: Jankovic J, Tolosa E, editors. Parkinson's disease & movement disorders. Sixth edition. ed. Baltimore, Maryland: Lippincott, Williams &Wilkins. pp. 481-503.
    [15] L S, FM V, MT M, et al. (2008) Obsessive-compulsive and Tourette Syndrome. In: Rosenberg RN, editor. The molecular and genetic basis of neurologic and psychiatric disease. 4th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins. pp. 802-816.
    [16] Zinner SH (2004) Tourette's Syndrome: Much More Than Tics. Contemporary Pediatrics. North Olmsted, Ohio: UBM Medica. pp. 27.
    [17] Mazefsky CA, Herrington J, Siegel M, et al. (2013) The role of emotion regulation in autism spectrum disorder. J Am Acad Child Adolesc Psychiatry 52: 679-688. doi: 10.1016/j.jaac.2013.05.006
    [18] Barnhill LJ, Horrigan JP (2002) Tourette's syndrome and autism: A search for common ground. Mental Health Aspects of Developmental Disabilities 5: 9.
    [19] Barnhill J (2011) Obsessive-Compulsive Disorders or Not: Differential Diagnosis of Repetitive Behaviors Among Individuals with Intellectual and Developmental Disorders. Different Views of Anxiety Disorders: 37.
    [20] Belin D, Belin-Rauscent A, Murray JE, et al. (2013) Addiction: failure of control over maladaptive incentive habits. Curr Opin Neurobiol 23: 564-572. doi: 10.1016/j.conb.2013.01.025
    [21] Gao S, Singer HS (2013) Complex motor stereotypies: an evolving neurobiological concept. Future Neurology 8: 273-285. doi: 10.2217/fnl.13.4
    [22] M B, ES B (2008) Psychiatric Diseases: Challenges in Psychiatric Genetics. In: Rosenberg RN, editor. The molecular and genetic basis of neurologic and psychiatric disease. 4th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins. pp. 749-758.
    [23] Nag A, Bochukova EG, Kremeyer B, et al. (2013) CNV analysis in Tourette syndrome implicates large genomic rearrangements in COL8A1 and NRXN1. PLoS One 8: e59061. doi: 10.1371/journal.pone.0059061
    [24] Fernandez TV, King RA, Pittenger C (2015) Tourette's syndrome and translational clinical science. J Am Acad Child Adolesc Psychiatry 54: 6-8. doi: 10.1016/j.jaac.2014.11.004
    [25] Gilbert DL (2006) Motor cortex inhibitory function in Tourette syndrome, attention deficit disorder, and obsessive compulsive disorder: studies using transcranial magnetic stimulation. Adv Neurol 99: 107-114.
    [26] Grant JE, Potenza MN, Weinstein A, et al. (2010) Introduction to behavioral addictions. Am J Drug Alcohol Abuse 36: 233-241. doi: 10.3109/00952990.2010.491884
    [27] Mathews CA, Grados MA (2011) Familiality of Tourette syndrome, obsessive-compulsive disorder, and attention-deficit/hyperactivity disorder: heritability analysis in a large sib-pair sample. J Am Acad Child Adolesc Psychiatry 50: 46-54. doi: 10.1016/j.jaac.2010.10.004
    [28] Gillan CM, Apergis-Schoute AM, Morein-Zamir S, et al. (2015) Functional neuroimaging of avoidance habits in obsessive-compulsive disorder. Am J Psychiatry 172: 284-293. doi: 10.1176/appi.ajp.2014.14040525
    [29] Peterson BS, Klein JE (1997) Neuroimaging and tourette's syndrome neurobiological substrate. Child and Adolescent Psychiatric Clinics of North America 6: 343-364.
    [30] Butler T, Stern E, Silbersweig D (2006) Functional neuroimaging of Tourette syndrome: advances and future directions. Adv Neurol 99: 115-129.
    [31] Muehlmann AM, Lewis MH (2012) Abnormal repetitive behaviours: shared phenomenology and pathophysiology. J Intellect Disabil Res 56: 427-440. doi: 10.1111/j.1365-2788.2011.01519.x
    [32] Levy R (2007) Neurobehavioral Disorders Associated with Basal Ganglia Disorders. In: Jankovic J, Tolosa E, editors. Parkinson's disease and movement disorders. 5th ed. Philadelphia: Lippincott Williams & Wilkins. pp. 23-32.
    [33] Smith JH, Smith VD, Philbrick KL, et al. (2012) Catatonic disorder due to a general medical or psychiatric condition. J Neuropsychiatry Clin Neurosci 24: 198-207. doi: 10.1176/appi.neuropsych.11060120
    [34] Schroeder SR, Oster-Granite ML, Berkson G, et al. (2001) Self-injurious behavior: gene-brain-behavior relationships. Ment Retard Dev Disabil Res Rev 7: 3-12.
    [35] Canitano R, Vivanti G (2007) Tics and Tourette syndrome in autism spectrum disorders. Autism 11: 19-28. doi: 10.1177/1362361307070992
    [36] Zandt F, Prior M, Kyrios M (2007) Repetitive behaviour in children with high functioning autism and obsessive compulsive disorder. J Autism Dev Disord 37: 251-259. doi: 10.1007/s10803-006-0158-2
    [37] Rapin I (2001) Autism spectrum disorders: relevance to Tourette syndrome. Adv Neurol 85: 89-101.
    [38] Mills S, Hedderly T (2014) A guide to childhood motor stereotypies, tic disorders and the tourette spectrum for the primary care practitioner. Ulster Med J 83: 22-30.
    [39] Fletcher RJ, Barnhill J, McCarthy J, et al. (2016) From DSM to DM-ID. Journal of Mental Health Research in Intellectual Disabilities 9: 189-204. doi: 10.1080/19315864.2016.1185324
    [40] Worbe Y, Gerardin E, Hartmann A, et al. (2010) Distinct structural changes underpin clinical phenotypes in patients with Gilles de la Tourette syndrome. Brain 133: 3649-3660. doi: 10.1093/brain/awq293
    [41] Gonzalez P, Martinez KG (2014) The role of stress and fear in the development of mental disorders. Psychiatr Clin North Am 37: 535-546. doi: 10.1016/j.psc.2014.08.010
    [42] Vidal-Ribas P, Stringaris A, Ruck C, et al. (2015) Are stressful life events causally related to the severity of obsessive-compulsive symptoms? A monozygotic twin difference study. Eur Psychiatry 30: 309-316.
    [43] Murphy TK, Lewin AB, Storch EA, et al. (2013) Practice Parameter for the Assessment and Treatment of Children and Adolescents With Tic Disorders. Journal of the American Academy of Child & Adolescent Psychiatry 52: 1341-1359.
    [44] Venkitaramani DV, Lombroso PJ (2007) Molecular basis of genetic neuropsychiatric disorders. Child Adolesc Psychiatr Clin N Am 16: 541-556. doi: 10.1016/j.chc.2007.03.003
    [45] Swain JE, Scahill L, Lombroso PJ, et al. (2007) Tourette syndrome and tic disorders: a decade of progress. J Am Acad Child Adolesc Psychiatry 46: 947-968. doi: 10.1097/chi.0b013e318068fbcc
    [46] Santangelo SL, Pauls DL, Goldstein JM, et al. (1994) Tourette's syndrome: what are the influences of gender and comorbid obsessive-compulsive disorder? J Am Acad Child Adolesc Psychiatry 33: 795-804. doi: 10.1097/00004583-199407000-00004
    [47] Barry S, Baird G, Lascelles K, et al. (2011) Neurodevelopmental movement disorders—an update on childhood motor stereotypies. Dev Med Child Neurol 53: 979-985. doi: 10.1111/j.1469-8749.2011.04058.x
    [48] Scahill L, Vaccorino, Flora M. Mercadante Marcos T. Lombroso Paul J. (2008) Obsessive-compulsive Disorder and Tourette Syndrome. In: Rosenberg RND, Salvatore. Paulson, Henry L. Ptacek, Louis, Nestler, Eric J. , editor. The molecular and genetic basis of neurologic and psychiatric disease. 4th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins. pp. 802-817.
    [49] State MW (2010) The genetics of child psychiatric disorders: focus on autism and Tourette syndrome. Neuron 68: 254-269. doi: 10.1016/j.neuron.2010.10.004
    [50] Price RA, Kidd KK, Cohen DJ, et al. (1985) A twin study of Tourette syndrome. Arch Gen Psychiatry 42: 815-820. doi: 10.1001/archpsyc.1985.01790310077011
    [51] Deng H, Gao K, Jankovic J (2012) The genetics of Tourette syndrome. Nat Rev Neurol 8: 203-213. doi: 10.1038/nrrheum.2012.2
    [52] O'Rourke JA, Scharf JM, Yu D, et al. (2009) The genetics of Tourette syndrome: a review. J Psychosom Res 67: 533-545. doi: 10.1016/j.jpsychores.2009.06.006
    [53] Mataix-Cols D, Isomura K, Perez-Vigil A, et al. (2015) Familial Risks of Tourette Syndrome and Chronic Tic Disorders. A Population-Based Cohort Study. JAMA Psychiatry 72: 787-793.
    [54] Browne HA, Hansen SN, Buxbaum JD, et al. (2015) Familial clustering of tic disorders and obsessive-compulsive disorder. JAMA Psychiatry 72: 359-366. doi: 10.1001/jamapsychiatry.2014.2656
    [55] Melchior L, Bertelsen B, Debes NM, et al. (2013) Microduplication of 15q13.3 and Xq21.31 in a family with Tourette syndrome and comorbidities. Am J Med Genet B Neuropsychiatr Genet 162B: 825-831.
    [56] Moya PR, Dodman NH, Timpano KR, et al. (2013) Rare missense neuronal cadherin gene (CDH2) variants in specific obsessive-compulsive disorder and Tourette disorder phenotypes. Eur J Hum Genet 21: 850-854. doi: 10.1038/ejhg.2012.245
    [57] Ercan-Sencicek AG, Stillman AA, Ghosh AK, et al. (2010) L-histidine decarboxylase and Tourette's syndrome. N Engl J Med 362: 1901-1908. doi: 10.1056/NEJMoa0907006
    [58] Castellan Baldan L, Williams KA, Gallezot JD, et al. (2014) Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice. Neuron 81: 77-90. doi: 10.1016/j.neuron.2013.10.052
    [59] Abelson JF, Kwan KY, O'Roak BJ, et al. (2005) Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science 310: 317-320. doi: 10.1126/science.1116502
    [60] O'Roak BJ, Morgan TM, Fishman DO, et al. (2010) Additional support for the association of SLITRK1 var321 and Tourette syndrome. Mol Psychiatry 15: 447-450. doi: 10.1038/mp.2009.105
    [61] Verkerk AJ, Mathews CA, Joosse M, et al. (2003) CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorder. Genomics 82: 1-9. doi: 10.1016/S0888-7543(03)00097-1
    [62] Sundaram SK, Huq AM, Wilson BJ, et al. (2010) Tourette syndrome is associated with recurrent exonic copy number variants. Neurology 74: 1583-1590. doi: 10.1212/WNL.0b013e3181e0f147
    [63] Lawson-Yuen A, Saldivar JS, Sommer S, et al. (2008) Familial deletion within NLGN4 associated with autism and Tourette syndrome. Eur J Hum Genet 16: 614-618. doi: 10.1038/sj.ejhg.5202006
    [64] Robertson MM, Shelley BP, Dalwai S, et al. (2006) A patient with both Gilles de la Tourette's syndrome and chromosome 22q11 deletion syndrome: clue to the genetics of Gilles de la Tourette's syndrome? J Psychosom Res 61: 365-368. doi: 10.1016/j.jpsychores.2006.06.011
    [65] Sundaram SK, Huq AM, Sun Z, et al. (2011) Exome sequencing of a pedigree with Tourette syndrome or chronic tic disorder. Ann Neurol 69: 901-904. doi: 10.1002/ana.22398
    [66] Scharf JM, Yu D, Mathews CA, et al. (2013) Genome-wide association study of Tourette's syndrome. Mol Psychiatry 18: 721-728. doi: 10.1038/mp.2012.69
    [67] Davis LK, Yu D, Keenan CL, et al. (2013) Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet 9: e1003864. doi: 10.1371/journal.pgen.1003864
    [68] Goodman WK, Grice DE, Lapidus KA, et al. (2014) Obsessive-compulsive disorder. Psychiatr Clin North Am 37: 257-267. doi: 10.1016/j.psc.2014.06.004
    [69] Addington AM, Rapoport JL (2012) Annual research review: impact of advances in genetics in understanding developmental psychopathology. J Child Psychol Psychiatry 53: 510-518. doi: 10.1111/j.1469-7610.2011.02478.x
    [70] Clarke RA, Lee S, Eapen V (2012) Pathogenetic model for Tourette syndrome delineates overlap with related neurodevelopmental disorders including Autism. Transl Psychiatry 2: e158. doi: 10.1038/tp.2012.75
    [71] Nayate A, Bradshaw JL, Rinehart NJ (2005) Autism and Asperger's disorder: are they movement disorders involving the cerebellum and/or basal ganglia? Brain Res Bull 67: 327-334. doi: 10.1016/j.brainresbull.2005.07.011
    [72] Hounie AG, do Rosario-Campos MC, Diniz JB, et al. (2006) Obsessive-compulsive disorder in Tourette syndrome. Adv Neurol 99: 22-38.
    [73] Kerbeshian J, Burd L (1992) Epidemiology and comorbidity. The North Dakota prevalence studies of Tourette syndrome and other developmental disorders. Adv Neurol 58: 67-74.
    [74] Baron-Cohen S, Mortimore C, Moriarty J, et al. (1999) The prevalence of Gilles de la Tourette's syndrome in children and adolescents with autism. J Child Psychol Psychiatry 40: 213-218. doi: 10.1111/1469-7610.00434
    [75] Arron K, Oliver C, Moss J, et al. (2011) The prevalence and phenomenology of self-injurious and aggressive behaviour in genetic syndromes. J Intellect Disabil Res 55: 109-120. doi: 10.1111/j.1365-2788.2010.01337.x
    [76] Tsankova N, Renthal W, Kumar A, et al. (2007) Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci 8: 355-367. doi: 10.1038/nrn2132
    [77] Cuthbert BN, Insel TR (2013) Toward the future of psychiatric diagnosis: the seven pillars of RDoC. BMC Med 11: 126. doi: 10.1186/1741-7015-11-126
    [78] 13. Jankovic J (2007) Tics and Tourette's Disorders in Children. In: Jankovic J, Tolosa E, editors. Parkinson's disease and movement disorders. 5th ed. Philadelphia: Lippincott Williams & Wilkins. pp. 356-375.
    [79] 14. Singer H (2007) Movement disorders in Children In: Jankovic J, Tolosa E, editors. Parkinson's disease & movement disorders. Sixth edition. ed. Baltimore, Maryland: Lippincott, Williams &Wilkins. pp. 481-503.
    [80] 32. Levy R (2007) Neurobehavioral Disorders Associated with Basal Ganglia Disorders. In: Jankovic J, Tolosa E, editors. Parkinson's disease and movement disorders. 5th ed. Philadelphia: Lippincott Williams & Wilkins. pp. 23-32.
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