The functional roles of T-cadherin in mammalian biology

Jade Sternberg; Miriam Wankell; V. Nathan Subramaniam; Lionel W. Hebbard; Jade Sternberg; Miriam Wankell; V. Nathan Subramaniam; Lionel W. Hebbard

doi:10.3934/molsci.2017.1.62

AIMS Molecular Science

2017, Volume 4, Issue 1: 62-81. doi: 10.3934/molsci.2017.1.62

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The functional roles of T-cadherin in mammalian biology

1.
College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Australia
2.
Comparative Genomics Centre, James Cook University, Townsville, Australia
3.
Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Australia
4.
Department of Molecular and Cell Biology, James Cook University, Townsville, Australia
5.
Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane. Australia

Received: 21 November 2016 Accepted: 26 January 2017 Published: 13 February 2017

T-cadherin is a cadherin and cell adhesion molecule that is anchored to the cell surface membrane through a glycosylphosphatidylinositol moiety. T-cadherin lacks a transmembrane and cytoskeletal domain, suggesting that it must interact with other membrane-bound molecules to elicit cellular signaling to modulate normal cellular functions, and alternatively its absence can be a factor in promoting neoplasia. Moreover, apart from binding to itself it can sequester adiponectin to the cell surface. Consistent with these observations, recent research has expanded the scope of T-cadherin’s role in cancer, neuronal function, metabolism and cardiovascular disease. In this context, we highlight the experimental and genomic evidence that links T-cadherin with these diseases. In particular, we discuss how T-cadherin homophilic and heterophilic interactions impact on signaling pathways and cellular behavior.
- T-cadherin,
- CDH13,
- adiponectin,
- metabolism,
- cancer
Citation: Jade Sternberg, Miriam Wankell, V. Nathan Subramaniam, Lionel W. Hebbard. The functional roles of T-cadherin in mammalian biology[J]. AIMS Molecular Science, 2017, 4(1): 62-81. doi: 10.3934/molsci.2017.1.62

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Abstract

T-cadherin is a cadherin and cell adhesion molecule that is anchored to the cell surface membrane through a glycosylphosphatidylinositol moiety. T-cadherin lacks a transmembrane and cytoskeletal domain, suggesting that it must interact with other membrane-bound molecules to elicit cellular signaling to modulate normal cellular functions, and alternatively its absence can be a factor in promoting neoplasia. Moreover, apart from binding to itself it can sequester adiponectin to the cell surface. Consistent with these observations, recent research has expanded the scope of T-cadherin’s role in cancer, neuronal function, metabolism and cardiovascular disease. In this context, we highlight the experimental and genomic evidence that links T-cadherin with these diseases. In particular, we discuss how T-cadherin homophilic and heterophilic interactions impact on signaling pathways and cellular behavior.

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