Cell proliferation control by Notch signalling during imaginal discs development in <em>Drosophila</em>

Carlos Estella; Antonio Baonza; Carlos Estella; Antonio Baonza

doi:10.3934/genet.2015.1.70

AIMS Genetics

2015, Volume 2, Issue 1: 70-96. doi: 10.3934/genet.2015.1.70

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Cell proliferation control by Notch signalling during imaginal discs development in Drosophila

Carlos Estella ¹,
Antonio Baonza ^{2
,
,}

1.
Departamento de Biología Molecular and Centro de Biología Molecular SeveroOchoa, Universidad Autónoma de Madrid (UAM), Madrid, Spain;
2.
Centro de Biología Molecular Severo Ochoa (CSIC/UAM) c/Nicolás Cabrera 1, 28049, Madrid, Spain

Received: 13 November 2014 Accepted: 25 January 2015 Published: 05 February 2015

The Notch signalling pathway is evolutionary conserved and participates in numerous developmental processes, including the control of cell proliferation. However, Notch signalling can promote or restrain cell division depending on the developmental context, as has been observed in human cancer where Notch can function as a tumor suppressor or an oncogene. Thus, the outcome of Notch signalling can be influenced by the cross-talk between Notch and other signalling pathways. The use of model organisms such as Drosophila has been proven to be very valuable to understand the developmental role of the Notch pathway in different tissues and its relationship with other signalling pathways during cell proliferation control. Here we review recent studies in Drosophila that shed light in the developmental control of cell proliferation by the Notch pathway in different contexts such as the eye, wing and leg imaginal discs. We also discuss the autonomous and non-autonomous effects of the Notch pathway on cell proliferation and its interactions with different signalling pathways.
- Drosophila,
- Notch signaling,
- imaginal discs,
- cell proliferation
Citation: Carlos Estella, Antonio Baonza. Cell proliferation control by Notch signalling during imaginal discs development in Drosophila[J]. AIMS Genetics, 2015, 2(1): 70-96. doi: 10.3934/genet.2015.1.70

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Abstract

The Notch signalling pathway is evolutionary conserved and participates in numerous developmental processes, including the control of cell proliferation. However, Notch signalling can promote or restrain cell division depending on the developmental context, as has been observed in human cancer where Notch can function as a tumor suppressor or an oncogene. Thus, the outcome of Notch signalling can be influenced by the cross-talk between Notch and other signalling pathways. The use of model organisms such as Drosophila has been proven to be very valuable to understand the developmental role of the Notch pathway in different tissues and its relationship with other signalling pathways during cell proliferation control. Here we review recent studies in Drosophila that shed light in the developmental control of cell proliferation by the Notch pathway in different contexts such as the eye, wing and leg imaginal discs. We also discuss the autonomous and non-autonomous effects of the Notch pathway on cell proliferation and its interactions with different signalling pathways.

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