Use of ketamine for depression and suicidality in cancer and terminal patients: Review of current data

Aderonke Oyetunji; Christian Huelga; Kailee Bunte; Rachel Tao; Val Bellman; Aderonke Oyetunji; Christian Huelga; Kailee Bunte; Rachel Tao; Val Bellman

doi:10.3934/publichealth.2023043

AIMS Public Health

2023, Volume 10, Issue 3: 610-626. doi: 10.3934/publichealth.2023043

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Review

Use of ketamine for depression and suicidality in cancer and terminal patients: Review of current data

1.
University of Missouri Kansas City, Psychiatry Residency Training Program, Kansas City, MO
2.
Kansas City University, College of Osteopathic Medicine, Kansas City, MO
3.
University of Missouri Kansas City, School of Medicine, Kansas City, MO

Received: 29 May 2023 Revised: 04 July 2023 Accepted: 05 July 2023 Published: 21 July 2023

Depression and suicidality are significant challenges faced by cancer patients, particularly those in advanced stages of the disease or nearing the end of life. Conventional antidepressant therapies often have limited effectiveness or delayed onset of action, making the exploration of alternative treatments crucial. The use of ketamine as a potential treatment for depression and suicidality in cancer and terminal patients has gained considerable attention in recent years. This review article aims to provide a comprehensive analysis of the current data regarding the efficacy and safety of ketamine in this specific population. This review presents an overview of clinical trials and case studies investigating the use of ketamine in this population. It explores the effectiveness of ketamine as a standalone treatment or in combination with other interventions. Furthermore, the article addresses the limitations and future directions of research in this field. It highlights the need for larger, well-controlled studies with long-term follow-up to establish the efficacy, safety and optimal treatment parameters of ketamine for depression and suicidality in palliative care.
- ketamine,
- depression,
- suicide,
- cancer,
- terminal illness
Citation: Aderonke Oyetunji, Christian Huelga, Kailee Bunte, Rachel Tao, Val Bellman. Use of ketamine for depression and suicidality in cancer and terminal patients: Review of current data[J]. AIMS Public Health, 2023, 10(3): 610-626. doi: 10.3934/publichealth.2023043

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Abstract

Depression and suicidality are significant challenges faced by cancer patients, particularly those in advanced stages of the disease or nearing the end of life. Conventional antidepressant therapies often have limited effectiveness or delayed onset of action, making the exploration of alternative treatments crucial. The use of ketamine as a potential treatment for depression and suicidality in cancer and terminal patients has gained considerable attention in recent years. This review article aims to provide a comprehensive analysis of the current data regarding the efficacy and safety of ketamine in this specific population. This review presents an overview of clinical trials and case studies investigating the use of ketamine in this population. It explores the effectiveness of ketamine as a standalone treatment or in combination with other interventions. Furthermore, the article addresses the limitations and future directions of research in this field. It highlights the need for larger, well-controlled studies with long-term follow-up to establish the efficacy, safety and optimal treatment parameters of ketamine for depression and suicidality in palliative care.

Acknowledgments

This study is not funded by any agency and is being conducted by the authors independently.

Conflict of Interest

The authors declare no conflict of interest.

References

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