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AIMS Molecular Science

2020, Volume 7, Issue 4: 328-348. doi: 10.3934/molsci.2020016
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Review

Genetic etiology of cleft lip and cleft palate

  • 1.
    Department of Orthodontics & Dentofacial Orthopedics, The Oxford Dental College, Bangalore, India
  • 2.
    Department of Orthodontics & Dentofacial Orthopedics, DAPM RV Dental College, Bangalore, India
  • 3.
    Department of Oral & Maxillofacial Surgery, Krishnadevaraya College of Dental Sciences, Bangalore, India
  • Received: 01 July 2020 Accepted: 07 September 2020 Published: 11 September 2020

  • Genetic studies in humans have demonstrated that Cleft lip with or without cleft palate (CL/P) have a diverse genetic background and probably environmental factors influencing these malformations. CL/P is one of the most common congenital birth defects in the craniofacial region with complex etiology involving multiple genetic factors, environmental factors and gene-environment interaction. Children born with these defects suffer from various difficulties such as difficulty in speech, hearing, feeding and other psychosocial problems, and their rehabilitation involves a multidisciplinary approach. The article describes the brief introduction of CL/P, epidemiology and general concepts, etiological factors, and the genes implicated in the etiology of nonsyndromic CL/P (NSCL/P) as suggested by different human genetic studies, animal models, and other expression studies.

    Citation: AN Mahamad Irfanulla Khan, CS Prashanth, N Srinath. Genetic etiology of cleft lip and cleft palate[J]. AIMS Molecular Science, 2020, 7(4): 328-348. doi: 10.3934/molsci.2020016

    Related Papers:

  • Genetic studies in humans have demonstrated that Cleft lip with or without cleft palate (CL/P) have a diverse genetic background and probably environmental factors influencing these malformations. CL/P is one of the most common congenital birth defects in the craniofacial region with complex etiology involving multiple genetic factors, environmental factors and gene-environment interaction. Children born with these defects suffer from various difficulties such as difficulty in speech, hearing, feeding and other psychosocial problems, and their rehabilitation involves a multidisciplinary approach. The article describes the brief introduction of CL/P, epidemiology and general concepts, etiological factors, and the genes implicated in the etiology of nonsyndromic CL/P (NSCL/P) as suggested by different human genetic studies, animal models, and other expression studies.


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    Conflict of interest


    All authors declare no conflicts of interest in this paper.

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