Skin aging and oxidative stress

Sayeeda Ahsanuddin; Minh Lam; Elma D. Baron; Sayeeda Ahsanuddin; Minh Lam; Elma D. Baron

doi:10.3934/molsci.2016.2.187

AIMS Molecular Science

2016, Volume 3, Issue 2: 187-195. doi: 10.3934/molsci.2016.2.187

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Review Topical Sections

Skin aging and oxidative stress

Department of Dermatology, Case Western Reserve University Hospitals, Cleveland, OH, USA

Received: 30 March 2016 Accepted: 26 April 2016 Published: 04 May 2016

Skin aging occurs through two main pathways, intrinsic and extrinsic. These pathways have significant interaction in contributing to the aging phenotype, which includes skin laxity, wrinkling, pigmentation irregularities, and the appearance of neoplastic skin lesions. Here, we review the critical role that oxidative stress plays in skin aging, including its effects on signaling pathways involved in skin matrix formation and degradation, proteasome activity, as well as DNA structure. Furthermore, we discuss the recent literature surrounding the prevention and treatment of skin aging. Although current research is suggestive of the role of antioxidants in anti-aging skin therapies, further research is much needed to explore its role in humans.
- Skin aging,
- photoaging,
- ROS,
- oxidative stress,
- antioxidants skin therapies
Citation: Sayeeda Ahsanuddin, Minh Lam, Elma D. Baron. Skin aging and oxidative stress[J]. AIMS Molecular Science, 2016, 3(2): 187-195. doi: 10.3934/molsci.2016.2.187

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Abstract

Skin aging occurs through two main pathways, intrinsic and extrinsic. These pathways have significant interaction in contributing to the aging phenotype, which includes skin laxity, wrinkling, pigmentation irregularities, and the appearance of neoplastic skin lesions. Here, we review the critical role that oxidative stress plays in skin aging, including its effects on signaling pathways involved in skin matrix formation and degradation, proteasome activity, as well as DNA structure. Furthermore, we discuss the recent literature surrounding the prevention and treatment of skin aging. Although current research is suggestive of the role of antioxidants in anti-aging skin therapies, further research is much needed to explore its role in humans.

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