Gene-environment interactions in considering physical activity for the prevention of dementia

Kristyn Alissa Bates; Kristyn Alissa Bates

doi:10.3934/molsci.2015.3.359

AIMS Molecular Science

2015, Volume 2, Issue 3: 359-381. doi: 10.3934/molsci.2015.3.359

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Review Special Issues

Gene-environment interactions in considering physical activity for the prevention of dementia

Kristyn Alissa Bates ^,

Experimental and Regenerative Neuroscience, School of Animal Biology, University of Western Australia, WA, Australia

Received: 29 June 2015 Accepted: 01 September 2015 Published: 08 September 2015

Alzheimer's disease (AD), the most common neurodegenerative disease worldwide, ranks as one of the most feared diseases in the world. Similarly, recent studies suggest that AD may be the third leading cause of death in the United States, behind heart disease and cancer. In the absence of a cure or effective treatment, strategies to prevent or delay the onset and progression of the disease are desperately needed. Decades of research have identified key risk and protective factors including genetic polymorphism in the APOE gene, age and lifestyle factors. Physical activity (PA) is emerging as an attractive primary prevention strategy. This review will summarise the latest findings supporting the role of physical activity in the prevention of AD, including possible mechanisms and the influence of genetics on disease prevention. Given that AD and other dementias are recognised as a world health priority, public health strategies are needed to incorporate promoting the health benefits of physical activity across the lifespan.
- Alzheimer's disease,
- physical activity,
- apolipoprotein E
Citation: Kristyn Alissa Bates. Gene-environment interactions in considering physical activity for the prevention of dementia[J]. AIMS Molecular Science, 2015, 2(3): 359-381. doi: 10.3934/molsci.2015.3.359

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Abstract

Alzheimer's disease (AD), the most common neurodegenerative disease worldwide, ranks as one of the most feared diseases in the world. Similarly, recent studies suggest that AD may be the third leading cause of death in the United States, behind heart disease and cancer. In the absence of a cure or effective treatment, strategies to prevent or delay the onset and progression of the disease are desperately needed. Decades of research have identified key risk and protective factors including genetic polymorphism in the APOE gene, age and lifestyle factors. Physical activity (PA) is emerging as an attractive primary prevention strategy. This review will summarise the latest findings supporting the role of physical activity in the prevention of AD, including possible mechanisms and the influence of genetics on disease prevention. Given that AD and other dementias are recognised as a world health priority, public health strategies are needed to incorporate promoting the health benefits of physical activity across the lifespan.

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