Online prediction of total sugar content and optimal control of glucose feed rate during chlortetracycline fermentation based on soft sensor modeling

Ping Wang; Qiaoyan Sun; Yuxin Qiao; Lili Liu; Xiang Han; Xiangguang Chen; Ping Wang; Qiaoyan Sun; Yuxin Qiao; Lili Liu; Xiang Han; Xiangguang Chen

doi:10.3934/mbe.2022500

Mathematical Biosciences and Engineering

2022, Volume 19, Issue 10: 10687-10709. doi: 10.3934/mbe.2022500

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Research article

Online prediction of total sugar content and optimal control of glucose feed rate during chlortetracycline fermentation based on soft sensor modeling

1.
Department of Electrical and Electronic Engineering, College of Engineering, Yantai Nanshan University, Longkou 265713, China
2.
School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China

Academic Editor: Yang Kuang

Received: 28 March 2022 Revised: 11 July 2022 Accepted: 13 July 2022 Published: 27 July 2022

In the process of chlortetracycline (CTC) fermentation, no instrument can be used to measure the total sugar content of the fermentation broth online due to its high viscosity and large amount of impurities, so it is difficult to realize the optimal control of glucose feed rate in the fermentation process. In order to solve this intractable problem, the relationship between on-line measurable parameters and total sugar content (One of the parameters that are difficult to measure online) in fermentation tank is deeply analyzed, and a new soft sensor model of total sugar content in fermentation tank and a new optimal control method of glucose feed rate are proposed in this paper. By selecting measurable variables of fermentation tank, determining different fermentation stages, constructing recursive fuzzy neural network (RFNN) and applying network rolling training method, an online soft sensor model of total sugar content is established. Based on the field multi-batch data, the change trend of the amount of glucose feed required at each fermentation stage is divided, and the online prediction of total sugar content and the optimal control strategy of glucose feed rate are realized by using the inference algorithm of expert experience regulation rules and soft sensor model of total sugar content. The experiment results in the real field demonstrate that the proposed scheme can effectively predict the total sugar content of fermentation broth online, optimize the control of glucose feed rate during fermentation process, reduce production cost and meet the requirements of production technology.
- chlortetracycline fermentation,
- total sugar content,
- soft sensor model,
- optimal control strategy,
- optimal control of glucose feed rate
Citation: Ping Wang, Qiaoyan Sun, Yuxin Qiao, Lili Liu, Xiang Han, Xiangguang Chen. Online prediction of total sugar content and optimal control of glucose feed rate during chlortetracycline fermentation based on soft sensor modeling[J]. Mathematical Biosciences and Engineering, 2022, 19(10): 10687-10709. doi: 10.3934/mbe.2022500

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Abstract

In the process of chlortetracycline (CTC) fermentation, no instrument can be used to measure the total sugar content of the fermentation broth online due to its high viscosity and large amount of impurities, so it is difficult to realize the optimal control of glucose feed rate in the fermentation process. In order to solve this intractable problem, the relationship between on-line measurable parameters and total sugar content (One of the parameters that are difficult to measure online) in fermentation tank is deeply analyzed, and a new soft sensor model of total sugar content in fermentation tank and a new optimal control method of glucose feed rate are proposed in this paper. By selecting measurable variables of fermentation tank, determining different fermentation stages, constructing recursive fuzzy neural network (RFNN) and applying network rolling training method, an online soft sensor model of total sugar content is established. Based on the field multi-batch data, the change trend of the amount of glucose feed required at each fermentation stage is divided, and the online prediction of total sugar content and the optimal control strategy of glucose feed rate are realized by using the inference algorithm of expert experience regulation rules and soft sensor model of total sugar content. The experiment results in the real field demonstrate that the proposed scheme can effectively predict the total sugar content of fermentation broth online, optimize the control of glucose feed rate during fermentation process, reduce production cost and meet the requirements of production technology.

References

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