Agglomeration and dissolution of iron oxide nanoparticles in simplest biological media

Anna Godymchuk; Alexey Ilyashenko; Yury Konyukhov; Peter Ogbuna Offor; Galiya Baisalova; Anna Godymchuk; Alexey Ilyashenko; Yury Konyukhov; Peter Ogbuna Offor; Galiya Baisalova

doi:10.3934/matersci.2022039

AIMS Materials Science

2022, Volume 9, Issue 4: 642-652. doi: 10.3934/matersci.2022039

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Agglomeration and dissolution of iron oxide nanoparticles in simplest biological media

1.
Department of Material Science, Tomsk Polytechnic University, 30 Lenina avenue, 634050, Tomsk, Russia
2.
Joint-Stock Company "Scientific and Industrial Centre Polyus", 56V Kirova Avenue, 634050, Tomsk, Russia
3.
Department of Functional Nanosystems and High Temperature Materials, National University of Science and Technology "MISiS", 4 Leninsky avenue, 119049, Moscow, Russia
4.
Metallurgical and Materials Engineering Department, Africa Centre of Excellence for Sustainable Power and Energy Development (ACE-SPED), University of Nigeria, 410001, Nsukka, Nigeria
5.
Department of Chemistry, L.N. Gumilyov Eurasian National University, 2 Satpayev Street, 010008, Astana, Kazakhstan

Received: 08 April 2022 Revised: 13 June 2022 Accepted: 04 July 2022 Published: 16 August 2022

Despite high medical and biological potential, the penetration of iron oxide nanoparticles (NPs) into a human body can cause their dissolution with subsequent accumulation of highly toxic iron compounds. The paper describes the agglomeration and dissolution behavior of differently sized α-Fe₂O₃ NPs in the simplest biological solutions. The average sizes of the initial NPs according to the BET analysis are 12, 32, and 115 nm. Within 30–60 min exposure, the particle size and concentration of iron released into the solutions increases in the suspensions, accompanied by an intensive change of NPs surface charge. After an hour of exposure, the colloidal properties do not change significantly, although the dissolution degree ambiguously fluctuates. It has been shown that the agglomeration of the particles in the simplest pulmonary fluid is lower than in the simplest sweat fluid, compared to the dissolution degree, which is much higher in the pulmonary fluid than in the sweat. The colloidal stability of suspensions reduces with a decrease of NPs' size, e.g., the average size of particles is 315,289, and 248 nm, while zeta potential is 2, 9, and 17 mV, respectively for 12, 32, and 115 nm NPs in 3-hour suspensions. It has been found that 24 h dissolution degree of α-Fe₂O₃ NPs reaches 2.3% and 0.4%, respectively, in the simplest pulmonary and sweat fluids. The mechanism of dissolution of hematite NPs in the slightly acidic and acidic mediums is proposed.
- iron oxide nanoparticles,
- agglomeration,
- dissolution,
- simplest sweat fluid,
- simplest pulmonary fluid
Citation: Anna Godymchuk, Alexey Ilyashenko, Yury Konyukhov, Peter Ogbuna Offor, Galiya Baisalova. Agglomeration and dissolution of iron oxide nanoparticles in simplest biological media[J]. AIMS Materials Science, 2022, 9(4): 642-652. doi: 10.3934/matersci.2022039

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Abstract

Despite high medical and biological potential, the penetration of iron oxide nanoparticles (NPs) into a human body can cause their dissolution with subsequent accumulation of highly toxic iron compounds. The paper describes the agglomeration and dissolution behavior of differently sized α-Fe₂O₃ NPs in the simplest biological solutions. The average sizes of the initial NPs according to the BET analysis are 12, 32, and 115 nm. Within 30–60 min exposure, the particle size and concentration of iron released into the solutions increases in the suspensions, accompanied by an intensive change of NPs surface charge. After an hour of exposure, the colloidal properties do not change significantly, although the dissolution degree ambiguously fluctuates. It has been shown that the agglomeration of the particles in the simplest pulmonary fluid is lower than in the simplest sweat fluid, compared to the dissolution degree, which is much higher in the pulmonary fluid than in the sweat. The colloidal stability of suspensions reduces with a decrease of NPs' size, e.g., the average size of particles is 315,289, and 248 nm, while zeta potential is 2, 9, and 17 mV, respectively for 12, 32, and 115 nm NPs in 3-hour suspensions. It has been found that 24 h dissolution degree of α-Fe₂O₃ NPs reaches 2.3% and 0.4%, respectively, in the simplest pulmonary and sweat fluids. The mechanism of dissolution of hematite NPs in the slightly acidic and acidic mediums is proposed.

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