Influence of dietary patterns in the pathophysiology of Huntington's Disease: A literature review

Ubaid Ansari; Dawnica Nadora; Meraj Alam; Jimmy Wen; Shaheryar Asad; Forshing Lui; Ubaid Ansari; Dawnica Nadora; Meraj Alam; Jimmy Wen; Shaheryar Asad; Forshing Lui

doi:10.3934/Neuroscience.2024005

AIMS Neuroscience

2024, Volume 11, Issue 2: 63-75. doi: 10.3934/Neuroscience.2024005

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Review

Influence of dietary patterns in the pathophysiology of Huntington's Disease: A literature review

California Northstate University College of Medicine, USA

Received: 01 January 2024 Revised: 02 April 2024 Accepted: 09 April 2024 Published: 12 April 2024

Huntington's disease (HD), a rare autosomal dominant neurodegenerative disease, causes the gradual deterioration of neurons in the basal ganglia, specifically in the striatum. HD displays a wide range of symptoms, from motor disturbances such as chorea, dystonia, and bradykinesia to more debilitating symptoms such as cognitive decline, behavioral abnormalities, and psychiatric disturbances. Current research suggests the potential use of dietary interventions as viable strategies for slowing the progression of HD. Most notably, the Mediterranean, vegan, carnivore, paleo, and ketogenic diets have gained attention due to their hypothesized impact on neuroprotection and symptomatic modulation in various neurodegenerative disorders. Despite substantial nutritional differences among these diets, they share a fundamental premise—that dietary factors have an influential impact in modifying pertinent biological pathways linked to neurodegeneration. Understanding the intricate interactions between these dietary regimens and HD pathogenesis could open avenues for personalized interventions tailored to the individual's specific needs and genetic background. Ultimately, elucidating the multifaceted effects of these diets on HD offers a promising framework for developing comprehensive therapeutic approaches that integrate dietary strategies with conventional treatments.
- Huntington's disease,
- neurodegenerative disease,
- mediterranean diet,
- vegan diet,
- carnivore diet,
- paleolithic diet,
- ketogenic diet
Citation: Ubaid Ansari, Dawnica Nadora, Meraj Alam, Jimmy Wen, Shaheryar Asad, Forshing Lui. Influence of dietary patterns in the pathophysiology of Huntington's Disease: A literature review[J]. AIMS Neuroscience, 2024, 11(2): 63-75. doi: 10.3934/Neuroscience.2024005

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Abstract

Huntington's disease (HD), a rare autosomal dominant neurodegenerative disease, causes the gradual deterioration of neurons in the basal ganglia, specifically in the striatum. HD displays a wide range of symptoms, from motor disturbances such as chorea, dystonia, and bradykinesia to more debilitating symptoms such as cognitive decline, behavioral abnormalities, and psychiatric disturbances. Current research suggests the potential use of dietary interventions as viable strategies for slowing the progression of HD. Most notably, the Mediterranean, vegan, carnivore, paleo, and ketogenic diets have gained attention due to their hypothesized impact on neuroprotection and symptomatic modulation in various neurodegenerative disorders. Despite substantial nutritional differences among these diets, they share a fundamental premise—that dietary factors have an influential impact in modifying pertinent biological pathways linked to neurodegeneration. Understanding the intricate interactions between these dietary regimens and HD pathogenesis could open avenues for personalized interventions tailored to the individual's specific needs and genetic background. Ultimately, elucidating the multifaceted effects of these diets on HD offers a promising framework for developing comprehensive therapeutic approaches that integrate dietary strategies with conventional treatments.

Conflict of interest

The authors declare no conflict of interest.

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