Editorial

Bacterial meningitis-induced demyelination: A logical fallacy or groundbreaking avenue in neuroscience?

  • Received: 24 May 2023 Accepted: 18 June 2023 Published: 25 June 2023
  • Citation: Tjokorda Istri Pramitasuri, Ni Made Susilawathi, AA Raka Sudewi. Bacterial meningitis-induced demyelination: A logical fallacy or groundbreaking avenue in neuroscience?[J]. AIMS Neuroscience, 2023, 10(2): 172-174. doi: 10.3934/Neuroscience.2023013

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    Acknowledgments



    TIP received scholarship which supports all of her academic works, including the publication of this manuscript from the Directorate of Resources, Directorate General of Higher Education, Ministry of Education, Culture, Research, and Technology, the Republic of Indonesia through Pendidikan Magister Menuju Doktor untuk Sarjana Unggul (PMDSU) scheme.

    Use of AI tools declaration



    The authors declare they have not used Artificial Intelligence (AI) tools in the creation of this article.

    Conflict of interest



    The authors declare that there were no financial or commercial ties that might be viewed as potential conflicts of interest with this manuscript.

    Author contributions



    TIP, NMS and AARS were involved in overall structure and elaboration of concepts for review. Manuscript writing was by TIP and NMS. All authors contributed to editing of the manuscript.

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    [3] Dimitrov LG, Turner B (2014) What's new in multiple sclerosis?. Br J Gen Pract 64: 612-613. https://doi.org/10.3399/bjgp14X682609
    [4] Ma Y, Sannino D, Linden JR, et al. (2023) Epsilon toxin-producing Clostridium perfringens colonize the multiple sclerosis gut microbiome overcoming CNS immune privilege. J Clin Invest 133. https://doi.org/10.1172/JCI163239
    [5] Linden JR, Flores C, Schmidt EF, et al. (2019) Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL. PLoS Pathog 15: e1008014. https://doi.org/10.1371/journal.ppat.1008014
    [6] Linden JR, Ma Y, Zhao B, et al. (2015) Clostridium perfringens Epsilon Toxin Causes Selective Death of Mature Oligodendrocytes and Central Nervous System Demyelination. mBio 6: e02513. https://doi.org/10.1128/mBio.02513-14
    [7] Bossu JL, Wioland L, Doussau F, et al. (2020) Epsilon Toxin from Clostridium perfringens Causes Inhibition of Potassium inward Rectifier (Kir) Channels in Oligodendrocytes. Toxins (Basel) 12. https://doi.org/10.3390/toxins12010036
    [8] Bokori-Brown M, Savva CG, Fernandes da Costa SP, et al. (2011) Molecular basis of toxicity of Clostridium perfringens epsilon toxin. FEBS J 278: 4589-4601. https://doi.org/10.1111/j.1742-4658.2011.08140.x
    [9] Wippel C, Maurer J, Fortsch C, et al. (2013) Bacterial cytolysin during meningitis disrupts the regulation of glutamate in the brain, leading to synaptic damage. PLoS Pathog 9: e1003380. https://doi.org/10.1371/journal.ppat.1003380
    [10] Zheng P, Zhao YX, Zhang AD, et al. (2009) Pathologic analysis of the brain from Streptococcus suis type 2 experimentally infected pigs. Vet Pathol 46: 531-535. https://doi.org/10.1354/vp.08-VP-0043-J-FL
    [11] Wioland L, Dupont JL, Doussau F, et al. (2015) Epsilon toxin from Clostridium perfringens acts on oligodendrocytes without forming pores, and causes demyelination. Cell Microbiol 17: 369-388. https://doi.org/10.1111/cmi.12373
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