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AIMS Neuroscience

2022, Volume 9, Issue 2: 277-287. doi: 10.3934/Neuroscience.2022015
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Assessment of behavioural problems in preschool and school going children with epilepsy

  • 1.
    M.B.B.S, M.D. Paediatrics, Fellow in Developmental Paediatrics, Department of Pediatrics, Saveetha medical college and hospital, Thandalam, Kancheepuram, Tamilnadu, 602105, India.
  • 2.
    M.B.B.S, M.D. Paediatrics, Professor, Department of Pediatrics, Saveetha medical college and hospital, Thandalam, Kancheepuram, Tamilnadu, 602105, India.
  • 3.
    M.B.B.S, D.C.H. Paediatrics, Senior Resident, Department of Pediatrics, Saveetha medical college and hospital, Thandalam, Kancheepuram, Tamilnadu, 602105, India.
  • 4.
    M.B.B.S, M.D. Paediatrics, Associate Professor, Department of Pediatrics, Saveetha medical college and hospital, Thandalam, Kancheepuram, Tamilnadu, 602105, India.
  • 5.
    M.B.B.S, Post graduate student, Department of Pediatrics, Saveetha medical college and hospital, Thandalam, Kancheepuram, Tamilnadu, 602105, India.
  • 6.
    M.B.B.S, Post graduate student, Department of Pediatrics, Saveetha medical college and hospital, Thandalam, Kancheepuram, Tamilnadu, 602105, India.
  • Received: 15 March 2022 Revised: 18 May 2022 Accepted: 20 May 2022 Published: 01 June 2022

  • Introduction

    Children with epilepsy are at greater risk of developing psychiatric and behavioural disorders such as attention deficit/hyperactivity disorder (ADHD), conduct disorder, autism spectrum disorder (ASD), as well as affective and aggressive disorders than normal children which may affect the well- being and quality of life of the child.

     Aim and Objectives

    This study aims at identifying behavioural problems in children with epilepsy enabling early diagnosis and intervention. The objectives were to assess the presence and type of behavioural problems in children with epilepsy.

     Methods

    A prospective cross-sectional study was conducted on children who were diagnosed as epilepsy in two age groups of 1.5–5 years and 6–18 years recruited by non-probability convenience sampling. Data regarding seizure semiology, clinical features and treatment were obtained. Children underwent IQ assessment, electroencephalogram and brain neuroimaging. Child Behaviour Check List (CBCL) was administered to parents or primary caregivers after obtaining informed consent. Results were analyzed for presence of behavioural problems using SPSS-23.

     Results

    In the study, out of 50 study subjects, 72% were between 6–18 years. 60% children had generalised seizures, 58% children had epilepsy for <2 years and abnormal EEG was present in 80% children. 6% children had behavioural problems and 4% had borderline presentations. Co-relation of behavioural problems with age was statistically significant with p value 0.027. Behavioural problems identified were aggressiveness and anxiety.

     Conclusion

    Childhood epilepsy is associated with behavioural problems along with other co-morbidities warranting a search during follow-up visits.

     Take-home message

    Early identification and treatment of behavioural problems in children with epilepsy by periodic assessment during follow up visits, careful selection of combination of drugs and appropriate dose can improve the overall outcome in children taking antiepileptic drugs (AEDs) for epilepsy.

    Citation: Harshitha Shanmuganathan, Radha Kumar, D.V. Lal, Chaudhary Devanand Gulab, E. Gayathri, Kesavaraj Pallavi Raja. Assessment of behavioural problems in preschool and school going children with epilepsy[J]. AIMS Neuroscience, 2022, 9(2): 277-287. doi: 10.3934/Neuroscience.2022015

    Related Papers:

  • Introduction

    Children with epilepsy are at greater risk of developing psychiatric and behavioural disorders such as attention deficit/hyperactivity disorder (ADHD), conduct disorder, autism spectrum disorder (ASD), as well as affective and aggressive disorders than normal children which may affect the well- being and quality of life of the child.

     Aim and Objectives

    This study aims at identifying behavioural problems in children with epilepsy enabling early diagnosis and intervention. The objectives were to assess the presence and type of behavioural problems in children with epilepsy.

     Methods

    A prospective cross-sectional study was conducted on children who were diagnosed as epilepsy in two age groups of 1.5–5 years and 6–18 years recruited by non-probability convenience sampling. Data regarding seizure semiology, clinical features and treatment were obtained. Children underwent IQ assessment, electroencephalogram and brain neuroimaging. Child Behaviour Check List (CBCL) was administered to parents or primary caregivers after obtaining informed consent. Results were analyzed for presence of behavioural problems using SPSS-23.

     Results

    In the study, out of 50 study subjects, 72% were between 6–18 years. 60% children had generalised seizures, 58% children had epilepsy for <2 years and abnormal EEG was present in 80% children. 6% children had behavioural problems and 4% had borderline presentations. Co-relation of behavioural problems with age was statistically significant with p value 0.027. Behavioural problems identified were aggressiveness and anxiety.

     Conclusion

    Childhood epilepsy is associated with behavioural problems along with other co-morbidities warranting a search during follow-up visits.

     Take-home message

    Early identification and treatment of behavioural problems in children with epilepsy by periodic assessment during follow up visits, careful selection of combination of drugs and appropriate dose can improve the overall outcome in children taking antiepileptic drugs (AEDs) for epilepsy.


    加载中

    Acknowledgments


    The authors acknowledge the immense help received from the scholar whose article are cited and included in references to this manuscript. The authors are also grateful to authors/publishers/editors of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

    Limitations of the Study


    Major limitations of the present study were small sample size; a larger sample could have brought in the effects. A comparison cohort would have been useful in this study design which was another limitation of the study. Larger study on Indian population on multidrug treatment may give more insight into its effect on behaviour. The generalisability of study findings is limited as the study was from a single centre with limited catchment area. Hence adequate caution needs to be exercised while generalizing the findings to population groups with different demographic structure. It was a onetime assessment of children with epilepsy those with borderline scores were not followed up.

    Source of financial support


    Nil.

    Conflict of interest


    None declared.

    [1] Fisher RS, Acevedo C, Arzimanoglou A, et al. (2014) ILAE Official Report: A practical clinical definition of epilepsy. Epilepsia 55. https://doi.org/10.1111/epi.12550
    [2] Amudhan S, Gururaj G, Satishchandra P (2015) Epilepsy in India I: Epidemiology and public health. Ann Indian Acad Neur 18: 263-277. https://doi.org/10.4103/0972-2327.160093
    [3] Camfield P, Camfield C (2015) Incidence, prevalence and aetiology of seizures and epilepsy in children. Epileptic Disord 17: 117-123. https://doi.org/10.1684/epd.2015.0736
    [4] Berg AT (2011) Epilepsy, cognition, and behavior: The clinical picture. Epilepsia 52: 7-12. https://doi.org/10.1111/j.1528-1167.2010.02905.x
    [5] Canto GD, Pellacani S, Valvo G, et al. (2017) Internalizing and externalizing symptoms in preschool and school-aged children with epilepsy: Focus on clinical and EEG features. Epilepsy Behav 79: 68-74. https://doi.org/10.1016/j.yebeh.2017.10.004
    [6] Brodie MJ, Besag F, Ettinger AB, et al. (2016) Epilepsy, Antiepileptic Drugs, and Aggression: An Evidence-Based Review. Pharmacol Rev 68: 563-602. https://doi.org/10.1124/pr.115.012021
    [7] Achenbach TM, Ruffle TM (2000) The Child Behavior Checklist and Related Forms for Assessing Behavioral/Emotional Problems and Competencies. Pediatr Rev 21: 265-271. https://doi.org/10.1542/pir.21.8.265
    [8] Shinnar S, Pellock JM (2002) Update on the epidemiology and prognosis of pediatric epilepsy. J Child Neurol 17: S4-17. https://doi.org/10.1177/08830738020170010201
    [9] Prakash J, Mitra AK, Prabhu HRA (2008) Child and behaviour: A school based study. Delhi Psychiatr J 11: 79-82.
    [10] Mishra OP, Upadhyay A, Prasad R, et al. (2017) Behavioral Problems in Indian Children with Epilepsy. Indian Pediatr 54: 116-120. https://doi.org/10.1007/s13312-017-1012-7
    [11] Achenbach TM, Edelbrock T (1991) Child Behavior Checklist. Burlington, VT: University of Vermont Department of Psychiatry 12-13.
    [12] Choudhary A, Gulati S, Sagar R, et al. (2014) Behavioral comorbidity in children and adolescents with epilepsy. J Clin Neurosci 21: 1337-1340. https://doi.org/10.1016/j.jocn.2013.11.023
    [13] Datta SS, Premkumar TS, Chandy S, et al. (2005) Behaviour problems in children and adolescents with seizure disorder: associations and risk factors. Seizure 14: 190-197. https://doi.org/10.1016/j.seizure.2005.01.007
    [14] Celen YT, Günbey C, Degerliyurt A, et al. (2019) Behavioral problems of preschool children with new-onset epilepsy and one-year follow-up - a prospective study. Epilepsy Behav 92: 171-175. https://doi.org/10.1016/j.yebeh.2018.12.025
    [15] Austin JK, Risinger MW, Beckett LA (1992) Correlates of behavior problems in children with epilepsy. Epilepsia 33: 1115-1122. https://doi.org/10.1111/j.1528-1157.1992.tb01768.x
    [16] Karanja SW, Kiburi SK, Kang'ethe R, et al. (2021) Emotional and behavioral problems in children with epilepsy attending the pediatric neurology clinic at a referral hospital in Kenya. Epilepsy Behav 114: 107477. https://doi.org/10.1016/j.yebeh.2020.107477
    [17] Novriska D, Sutomo R, Setyati A (2014) Behavioral problems in children with epilepsy. Paediatr Indones 54: 324. https://doi.org/10.14238/pi54.6.2014.324-9
    [18] Matonda-ma-Nzuzi T, Mampunza Ma Miezi S, Nkosi Mpembi M, et al. (2007) Factors associated with behavioral problems and cognitive impairment in children with epilepsy of Kinshasa, Democratic Republic of the Congo. Epilepsy Behav 78: 78-83. https://doi.org/10.1016/j.yebeh.2017.08.030
    [19] Camfield PR, Gates R, Ronen G, et al. (1984) Comparison of cognitive ability, personality profile, school success in children with epilepsy with pure right versus pure left temporal lobe EEG foci. Ann Neurol 15: 122-126. https://doi.org/10.1002/ana.410150203
    [20] Hermann BP (1982) Neuropsychological functioning and psychopathology in children with epilepsy. Epilepsia 23: 545-554. https://doi.org/10.1111/j.1528-1157.1982.tb05440.x
    [21] Schoenfeld J, Seidenberg M, Woodard A, et al. (2007) Neuropsychological and behavioral status of children with complex partial seizures. Dev Med Child Neurol 41: 724-731. https://doi.org/10.1111/j.1469-8749.1999.tb00532.x
    [22] Operto FF, Smirni D, Scuoppo C, et al. (2021) Neuropsychological profile, emotional/behavioral problems, and parental stress in children with neurodevelopmental disorders. Brain Sci 11: 584. https://doi.org/10.3390/brainsci11050584
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