Alice in Wonderland syndrome (AIWS): a research overview

Md Mahbub Hossain; Md Mahbub Hossain

doi:10.3934/Neuroscience.2020024

AIMS Neuroscience

2020, Volume 7, Issue 4: 389-400. doi: 10.3934/Neuroscience.2020024

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Review

Alice in Wonderland syndrome (AIWS): a research overview

Md Mahbub Hossain ^{1,2,3
,
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1.
Nature Study Society of Bangladesh, Khulna 09000, Bangladesh
2.
EviSyn Health, Khulna 09000, Bangladesh
3.
Department of Health Promotion and Community Health Sciences, Texas A&M School of Public Health, College Station, TX 77843, USA

Received: 19 August 2020 Accepted: 09 October 2020 Published: 19 October 2020

Background Alice in Wonderland syndrome (AIWS) is a rare neuropsychiatric condition characterized by distorted visual perceptions, body schema, and experience of time. A global overview of research on AIWS can inform future developments and clinical practice in this field. This bibliometric study aimed to analyze the characteristics of the global research landscape on AIWS.
Methods Bibliometric data on AIWS related publications published until 2019 were retrieved from the Web of Science database. The data were analyzed using statistical and scientometric tools to evaluate the publication trends, key research domains, top contributing journals, institutions, and countries associated with AIWS-related research.
Results A total of 125 published items were analyzed with a mean of 3 authors and 8.15 citations per document. Most articles were published after 2008, in medical journals focused on neuropsychiatric sciences, and most institutions affiliated with AIWS research were based on high-income countries. Major research domains associated with AIWS included visual disturbances, body image, migraine, infections, risk factors, and other clinical correlates. Several overarching domains were identified; however, clinical research on diagnosis, treatment, and prognosis of AIWS is relatively limited.
Conclusion The current research landscape informs a developing trend in AIWS research in selected regions and specialties. Future research should emphasize multidisciplinary and translational investigations on clinical and epidemiological areas through global collaborations that may advance the knowledge and practice on AIWS.
- Alice in Wonderland syndrome,
- Todd's syndrome,
- pediatric neurology,
- neuroscience,
- bibliometrics
Citation: Md Mahbub Hossain. Alice in Wonderland syndrome (AIWS): a research overview[J]. AIMS Neuroscience, 2020, 7(4): 389-400. doi: 10.3934/Neuroscience.2020024

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Abstract

Background Alice in Wonderland syndrome (AIWS) is a rare neuropsychiatric condition characterized by distorted visual perceptions, body schema, and experience of time. A global overview of research on AIWS can inform future developments and clinical practice in this field. This bibliometric study aimed to analyze the characteristics of the global research landscape on AIWS.

Methods Bibliometric data on AIWS related publications published until 2019 were retrieved from the Web of Science database. The data were analyzed using statistical and scientometric tools to evaluate the publication trends, key research domains, top contributing journals, institutions, and countries associated with AIWS-related research.

Results A total of 125 published items were analyzed with a mean of 3 authors and 8.15 citations per document. Most articles were published after 2008, in medical journals focused on neuropsychiatric sciences, and most institutions affiliated with AIWS research were based on high-income countries. Major research domains associated with AIWS included visual disturbances, body image, migraine, infections, risk factors, and other clinical correlates. Several overarching domains were identified; however, clinical research on diagnosis, treatment, and prognosis of AIWS is relatively limited.

Conclusion The current research landscape informs a developing trend in AIWS research in selected regions and specialties. Future research should emphasize multidisciplinary and translational investigations on clinical and epidemiological areas through global collaborations that may advance the knowledge and practice on AIWS.

Conflicts of interest

The author declared no conflict of interest.

References

[1]	Lerner AG, Ran SL (2015) LSD-associated “Alice in Wonderland Syndrome” (AIWS): A Hallucinogen Persisting Perception Disorder (HPPD) Case Report. Isr J Psychiatry Relat Sci 52: 67-69.
[2]	Farooq O, Fine EJ (2017) Alice in Wonderland Syndrome: A Historical and Medical Review. Pediatr Neurol 77: 5-11. doi: 10.1016/j.pediatrneurol.2017.08.008
[3]	Fine E, Farooq O, Finnegan S, et al. (2019) Alice in Wonderland Syndrome: Case Series and Analysis. Neurology 92.
[4]	Blom JD (2016) Alice in Wonderland syndrome A systematic review. Neurol Clin Pract 6: 259-270. doi: 10.1212/CPJ.0000000000000251
[5]	Paniz-Mondolfi AE, Giraldo J, Rodriguez-Morales AJ, et al. (2018) Alice in Wonderland syndrome: a novel neurological presentation of Zika virus infection. J NeuroVirol 24: 660-663. doi: 10.1007/s13365-018-0645-1
[6]	Harrison B, Harrison A (2015) Through the Looking Glass: A Literature Review of a Rare Pediatric Neuropsychiatric Condition: Alice in Wonderland (Todd's) Syndrome. Univ Ottawa J Med 5: 46-49. doi: 10.18192/uojm.v5i2.1281
[7]	Lopes MT, Koch VH, Sarrubbi-Junior V, et al. (2018) Difficulties in the diagnosis and treatment of rare diseases according to the perceptions of patients, relatives and health care professionals. Clinics 73: e68.
[8]	Garcia-Cabo C, Fernandez-Dominguez J, Garcia-Rodriguez R, et al. (2019) Alice in Wonderland syndrome as the initial and sole manifestation of ischaemic stroke. Neurologia 34: 487-488. doi: 10.1016/j.nrl.2016.10.011
[9]	Hossain MM, Sultana A, Shaik AF, et al. (2020) Psychoanalysis in the era of precision psychiatry. Asian J Psychiatry 47. doi: 10.1016/j.ajp.2019.10.020
[10]	Hossain MM (2020) Current Status of Global Research on Novel Coronavirus Disease (COVID-19): A Bibliometric Analysis and Knowledge Mapping. F1000Research 9: 374. doi: 10.12688/f1000research.23690.1
[11]	Fodor KE, Unterhitzenberger J, Chou CY, et al. (2014) Is traumatic stress research global? A bibliometric analysis. Eur J Psychotraumatol 5. doi: 10.3402/ejpt.v5.23269
[12]	Falagas ME, Papastamataki PA, Bliziotis IA (2006) A bibliometric analysis of research productivity in parasitology by different world regions during a 9-year period (1995–2003). BMC Infect Dis 6: 1-6. doi: 10.1186/1471-2334-6-1
[13]	Hossain MM (2020) Umbrella review as an emerging approach of evidence synthesis in health sciences: A bibliometric analysis. SSRN Available from: http//ssrn.com/abstract=3551055.
[14]	Saheb T, Saheb M (2019) Analyzing and visualizing knowledge structures of health informatics from 1974 to 2018: A bibliometric and social network analysis. Healthc Inform Res 25: 61-72. doi: 10.4258/hir.2019.25.2.61
[15]	Hossain MM, Sarwar SA, McKyer ELJ, et al. (2020) Applications of Artificial Intelligence Technologies in COVID-19 Research: A Bibliometric Study. Preprints Available from: https://europepmc.org/article/ppr/ppr175749.
[16]	Peng RZ, Zhu C, Wu WP (2020) Visualizing the knowledge domain of intercultural competence research: A bibliometric analysis. Int J Intercult Relat 74: 58-68. doi: 10.1016/j.ijintrel.2019.10.008
[17]	Hernández-Torrano D, Ibrayeva L, Sparks J, et al. (2020) Mental Health and Well-Being of University Students: A Bibliometric Mapping of the Literature. Front Psychol 11: 1226. doi: 10.3389/fpsyg.2020.01226
[18]	Hossain MM (2020) Global research overview of Alice in Wonderland syndrome (AIWS): a bibliometric study. OSF Regist 4.
[19]	Pitron V, Alsmith A, De Vignemont F (2018) How do the body schema and the body image interact? Conscious Cogn 65: 352-358. doi: 10.1016/j.concog.2018.08.007
[20]	Losada-Del Pozo R, Cantarin-Extremera V, Garcia-Penas JJ, et al. (2011) Characteristics and evolution of patients with Alice in Wonderland syndrome. Rev Neurol 53: 641-648.
[21]	Hamed SA (2010) A migraine variant with abdominal colic and Alice in wonderland syndrome: a case report and review. BMC Neurol 10: 2. doi: 10.1186/1471-2377-10-2
[22]	Beh SC, Masrour S, Smith VS, et al. (2018) Clinical characteristics of Alice in Wonderland syndrome in a cohort with vestibular migraine. Neurol Clin Pract 8: 389-396. doi: 10.1212/CPJ.0000000000000518
[23]	Cinbis M, Aysun S (1992) Alice-in-wonderland syndrome as initial manifestation of Epstein-Barr virus infection. Br J Ophthalmol 76: 316. doi: 10.1136/bjo.76.5.316
[24]	O'Toole P, Modestino EJ (2017) Alice in Wonderland Syndrome: A real life version of Lewis Carroll's novel. Brain Dev 39: 470-474. doi: 10.1016/j.braindev.2017.01.004
[25]	Hausler M, Ramaekers VT, Doenges M, et al. (2002) Neurological complications of acute and persistent Epstein-Barr virus infection in paediatric patients. J Med Virol 68: 253-263. doi: 10.1002/jmv.10201
[26]	Kuo YT, Chiu NC, Shen EY, et al. (1998) Cerebral perfusion in children with Alice in Wonderland syndrome. Pediatr Neurol 19: 105-108. doi: 10.1016/S0887-8994(98)00037-X
[27]	Lahat E, Eshel G, Arlazoroff A (1990) Alice-in-Wonderland Syndrome and Infectious Mononucleosis in Children. Ann Neurol 28: 461-462. doi: 10.1002/ana.410280317
[28]	Gomez-Sanchez D, Ros-Cervera G, Perez-Verdu J, et al. (2019) Aura without migraine or Alice in Wonderland syndrome. Pediatric clinical case. Arch Argent Pediatr 117: E34-E36.
[29]	Romanos M (2004) Migrainous complex hallucinations in 10-year old patient—a case report and review. Z Kinder Jugendpsychiatr Psychother 32: 201-207. doi: 10.1024/1422-4917.32.3.201
[30]	Naarden T, Ter Meulen BC, Van Der Weele SI, et al. (2019) Alice in Wonderland Syndrome as a Presenting Manifestation of Creutzfeldt-Jakob Disease. Front Neurol 10: 473. doi: 10.3389/fneur.2019.00473
[31]	Luat AF, Kamat D, Sivaswamy L (2015) Paroxysmal Nonepileptic Events in Infancy, Childhood, and Adolescence. Pediatr Ann 44: E18-E23. doi: 10.3928/00904481-20150203-07
[32]	Blom JD, Looijestijn J, Goekoop R, et al. (2011) Treatment of Alice in Wonderland Syndrome and Verbal Auditory Hallucinations Using Repetitive Transcranial Magnetic Stimulation: A Case Report with fMRI Findings. Psychopathology 44: 337-344. doi: 10.1159/000325102
[33]	Weidenfeld A, Borusiak P (2011) Alice-in-Wonderland syndrome-a case-based update and long-term outcome in nine children. Childs Nerv Syst 27: 893-896. doi: 10.1007/s00381-011-1400-6
[34]	Yokoyama T, Okamura T, Takahashi M, et al. (2017) A case of recurrent depressive disorder presenting with Alice in Wonderland syndrome: psychopathology and pre- and post-treatment FDG-PET findings. BMC Psychiatry 17. doi: 10.1186/s12888-017-1314-2
[35]	Sitthi-Amorn C (2000) Strengthening health research capacity in developing countries: a critical element for achieving health equity Commentary: Health research and human development in Papua New Guinea Commentary: Does strengthening research capacity improve health equity? BMJ 321: 813-817. doi: 10.1136/bmj.321.7264.813
[36]	Hossain MM, Sultana A, Tasnim S, et al. (2020) Prevalence of mental disorders among people who are homeless: An umbrella review. Int J Soc Psychiatry 66: 528-541. doi: 10.1177/0020764020924689
[37]	Hossain MM, Khan N, Sultana A, et al. (2020) Prevalence of comorbid psychiatric disorders among people with autism spectrum disorder: An umbrella review of systematic reviews and meta-analyses. Psychiatry Res 112922.
[38]	Jia Y, Miao Y (2018) Evidence for the Perception of Time Distortion During Episodes of Alice in Wonderland Syndrome. J Nerv Ment Dis 206: 473-475. doi: 10.1097/NMD.0000000000000825
[39]	Fine EJ (2013) The Alice in Wonderland Syndrome. Literature, Neurology, and Neuroscience: Neurological and Psychiatric Disorders Sara Burgerhartstraat 25, Po Box 211, 1000 Ae Amsterdam, Netherlands, Elsevier Science Bv, 143-156. doi: 10.1016/B978-0-444-63364-4.00025-9
[40]	Mastria G, Mancini V, Vigano A, et al. (2016) Alice in Wonderland Syndrome: A Clinical and Pathophysiological Review. Biomed Res Int 2016: 8243145. doi: 10.1155/2016/8243145

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