Histone glycation: Linking metabolic perturbation with epigenetic misregulation in cancer

Xiayao Diao; Xiayao Diao

doi:10.3934/genet.2019.2.14

AIMS Genetics

2019, Volume 6, Issue 2: 14-16. doi: 10.3934/genet.2019.2.14

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Histone glycation: Linking metabolic perturbation with epigenetic misregulation in cancer

Xiayao Diao ^,

Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 33 Yingfeng Road, Haizhu District, Guangzhou 510220, P. R. China

Received: 31 May 2019 Accepted: 31 May 2019 Published: 04 June 2019

Citation: Xiayao Diao. Histone glycation: Linking metabolic perturbation with epigenetic misregulation in cancer[J]. AIMS Genetics, 2019, 6(2): 14-16. doi: 10.3934/genet.2019.2.14

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Abbreviation ROS: Reactive oxygen species; MGO: Methylglyoxal; AGE: Advanced glycation end-product; NCP: Nucleosome core particle; PTM: Post-translational modification;

Conflict of interest

The authors declare no conflict of interest.

References

[1]	Wang Y, Xia Y, Lu Z (2018) Metabolic features of cancer cells. Cancer Commun 38: 65. doi: 10.1186/s40880-018-0335-7
[2]	Wang Y, Lei Q (2018) Metabolic recoding of epigenetics in cancer. Cancer Commun 38: 25. doi: 10.1186/s40880-018-0302-3
[3]	Oya T, Hattori N, Mizuno Y, et al. (1999) Methylglyoxal modification of protein. Chemical and immunochemical characterization of methylglyoxal-arginine adducts. J Biol Chem 274: 18492–18502.
[4]	Perche F, Biswas S, Patel NR, et al. (2016) Hypoxia-Responsive Copolymer for siRNA Delivery. Methods Mol Biol 1372: 139–162. doi: 10.1007/978-1-4939-3148-4_12
[5]	Jenuwein T, Allis CD (2001) Translating the histone code. Science 293: 1074–1080. doi: 10.1126/science.1063127
[6]	Bartholomew B (2014) Regulating the chromatin landscape: Structural and mechanistic perspectives. Annu Rev Biochem 83: 671–696. doi: 10.1146/annurev-biochem-051810-093157
[7]	Guedes S, Vitorino R, Domingues MR, et al. (2011) Glycation and oxidation of histones H2B and H1: In vitro study and characterization by mass spectrometry. Anal Bioanal Chem 399: 3529–3539. doi: 10.1007/s00216-011-4679-y
[8]	Zheng Q, Omans ND, Leicher R, et al. (2019) Reversible histone glycation is associated with disease-related changes in chromatin architecture. Nature Commun 10: 1289. doi: 10.1038/s41467-019-09192-z
[9]	Ariga H (2017) DJ-1/PARK7 Protein: Parkinson's Disease, Cancer and Oxidative Stress-Induced Diseases. Adv Exp Med Biol 1037: 224.
[10]	Cao J, Lou S, Ying M, et al. (2015) DJ-1 as a human oncogene and potential therapeutic target. Biochem Pharmacol 93: 241–250. doi: 10.1016/j.bcp.2014.11.012

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