Manuscript Topics

An emerging function of microRNA (miRNA) molecules and extracellular vesicles (EVs) in immune cell-to-cell communication has recently received special attention from researchers and clinicians, immunologists and allergists. Growing evidence suggests that they are also an important part of intercellular signaling pathways underlying both the pathogenesis of allergies and the development of immune tolerance. Thus, due to their complex role in physiological and pathological conditions, miRNAs and EVs could be considered as disease biomarkers, immune regulators and therapeutic agents. Simultaneously, modulating the miRNA- and EV-mediated signaling cascades could also induce beneficial therapeutic effects.

miRNA molecules interfere with messenger RNA (mRNA) to regulate gene expression and protein synthesis. In extracellular milieu, miRNAs can both circulate freely and be transferred by EVs. The latter allows selective or even antigen-specific targeting of desired cells by miRNAs to induce expected biological effects. In addition, EVs, including exosomes and microvesicles that differ in their biogenesis pathways, can also selectively deliver other biologically active molecules, or even antigens and allergens. Therefore, understanding the comprehensive functions of miRNAs and EVs in allergies and immune tolerance would contribute to uncovering their immunotherapeutic potential as well as would greatly increase the knowledge on the complex intercellular signaling pathways involved in pathogenesis of allergic diseases and maintaining/restoring of antigen-specific immune tolerance.

Potential topics include, but are not restricted to
• Role of miRNAs and EVs in pathogenesis of allergies
• Therapeutic potential of miRNAs and EVs in allergies
• miRNAs and EVs and biomarkers in allergies
• Role of miRNAs and EVs in maintaining the antigen-specific immune tolerance
• Role of miRNAs and EVs in restoring the antigen-specific immune tolerance

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