Validated input:
75 isolates; 64 patients; 37 isolates obtained after documented linezolid treatment.

R version: R version 4.6.1 (2026-06-24 ucrt) 

Primary isolate-level comparisons
     analysis population        outcome prior_LZD_n prior_LZD_median
 All isolates        All       MIC_mg_L          37             48.0
 All isolates        All G2576T_percent          37             67.1
 All isolates        ST7       MIC_mg_L          11             32.0
 All isolates        ST7 G2576T_percent          11             54.6
 All isolates     ST1192       MIC_mg_L          18            256.0
 All isolates     ST1192 G2576T_percent          18             96.4
 prior_LZD_Q1 prior_LZD_Q3 no_prior_LZD_n no_prior_LZD_median no_prior_LZD_Q1
        24.00      256.000             38               32.00           24.00
        48.00       96.100             38               62.40           49.30
        18.00       64.000             19               24.00           16.00
        33.75       64.750             19               50.20           46.55
        36.00      256.000             16               48.00           32.00
        80.25       97.525             16               83.15           65.90
 no_prior_LZD_Q3     U   p_value
          60.000 813.5 0.2354391
          83.725 766.5 0.5043435
          32.000 117.0 0.5999362
          61.550 105.0 1.0000000
         256.000 172.5 0.3084500
          96.850 180.0 0.2204845

First-isolate sensitivity analysis
                  analysis population        outcome prior_LZD_n
 First isolate per patient        All       MIC_mg_L          28
 First isolate per patient        All G2576T_percent          28
 First isolate per patient        ST7       MIC_mg_L          11
 First isolate per patient        ST7 G2576T_percent          11
 First isolate per patient     ST1192       MIC_mg_L          11
 First isolate per patient     ST1192 G2576T_percent          11
 prior_LZD_median prior_LZD_Q1 prior_LZD_Q3 no_prior_LZD_n no_prior_LZD_median
             48.0        30.00       256.00             36                32.0
             63.5        43.00        80.25             36                62.4
             32.0        18.00        64.00             18                28.0
             54.6        33.75        64.75             18                50.3
            256.0        72.00       256.00             15                48.0
             82.6        79.85        96.75             15                82.0
 no_prior_LZD_Q1 no_prior_LZD_Q3     U   p_value
          22.000          80.000 587.5 0.2524723
          49.900          82.575 486.0 0.8127760
          16.000          32.000 110.0 0.6318002
          46.125          62.525  99.0 1.0000000
          32.000         256.000 109.0 0.1518844
          65.600          96.750  90.0 0.7162419

ST1192 versus ST7
        outcome ST1192_n ST1192_median ST1192_Q1 ST1192_Q3 ST7_n ST7_median
       MIC_mg_L       34         80.00     32.00   256.000    30       28.0
 G2576T_percent       34         86.25     79.55    97.225    30       50.3
 ST7_Q1 ST7_Q3     U      p_value Hodges_Lehmann_difference   CI_low   CI_high
  16.00  32.00 244.0 2.601724e-04                  32.00002 10.00000 192.00001
  45.25  63.65  86.5 1.261476e-08                  32.87048 29.20007  45.19997

Spearman correlations between G2576T frequency and MIC
   Population  n Spearman_rho      p_value
 All isolates 75    0.6046755 9.187058e-09
          ST7 30    0.5118092 3.839683e-03
       ST1192 34    0.2545741 1.462380e-01
