Neuropsychological Patterns Following Lesions of the Anterior Insula in a Series of Forty Neurosurgical Patients

Barbara Tomasino; Dario Marin; Cinzia Canderan; Marta Maieron; Miran Skrap; Raffaella Ida Rumiati; Barbara Tomasino; Dario Marin; Cinzia Canderan; Marta Maieron; Miran Skrap; Raffaella Ida Rumiati

doi:10.3934/Neuroscience.2014.3.225

AIMS Neuroscience

2014, Volume 1, Issue 3: 225-244. doi: 10.3934/Neuroscience.2014.3.225

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Research article Special Issues

Neuropsychological Patterns Following Lesions of the Anterior Insula in a Series of Forty Neurosurgical Patients

1.
IRCCS “E. Medea”, San Vito al Tagliamento (PN), (37038), Italy;
2.
Fisica medica A.O.S. Maria della Misericordia, Udine, (33100), Italy;
3.
Unità Operativa di Neurochirurgia, A.O.S. Maria della Misericordia, Udine, (33100), Italy;
4.
Cognitive Neuroscience Sector, SISSA, Trieste, (34136), Italy

Received: 12 November 2014 Accepted: 15 December 2014 Published: 21 December 2014

In the present study we investigated the effects of lesions affecting mainly the anterior insula in a series of 22 patients with lesions in the left hemisphere (LH), and 18 patients with lesions involving the right hemisphere (RH). The site of the lesion was established by performing an overlap of the probabilistic cytoarchitectonic maps of the posterior insula. Here we report the patients’ neuropsychological profile and an analysis of their pre-surgical symptoms. We found that pre-operatory symptoms significantly differed in patients depending on whether the lesion affected the right or left insula and a strict parallelism between the patterns emerged in the pre-surgery symptoms analysis, and the patients’ cognitive profile. In particular, we found that LH patients showed cognitive deficits. By contrast, the RH patients, with the exception of one case showing an impaired performance at the visuo-spatial planning test were within the normal range in performing all the tests. In addition, a sub-group of patients underwent to the post-surgery follow-up examination.
- insula,
- glioma,
- neurosurgery,
- neuropsychology,
- lesion mapping
Citation: Barbara Tomasino, Dario Marin, Cinzia Canderan, Marta Maieron, Miran Skrap, Raffaella Ida Rumiati. Neuropsychological Patterns Following Lesions of the Anterior Insula in a Series of Forty Neurosurgical Patients[J]. AIMS Neuroscience, 2014, 1(3): 225-244. doi: 10.3934/Neuroscience.2014.3.225

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Abstract

In the present study we investigated the effects of lesions affecting mainly the anterior insula in a series of 22 patients with lesions in the left hemisphere (LH), and 18 patients with lesions involving the right hemisphere (RH). The site of the lesion was established by performing an overlap of the probabilistic cytoarchitectonic maps of the posterior insula. Here we report the patients’ neuropsychological profile and an analysis of their pre-surgical symptoms. We found that pre-operatory symptoms significantly differed in patients depending on whether the lesion affected the right or left insula and a strict parallelism between the patterns emerged in the pre-surgery symptoms analysis, and the patients’ cognitive profile. In particular, we found that LH patients showed cognitive deficits. By contrast, the RH patients, with the exception of one case showing an impaired performance at the visuo-spatial planning test were within the normal range in performing all the tests. In addition, a sub-group of patients underwent to the post-surgery follow-up examination.

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