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AIMS Biophysics

2017, Volume 4, Issue 4: 596-614. doi: 10.3934/biophy.2017.4.596
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Review Special Issues

Role of free radicals in human inflammatory diseases

  • Immunobiology and Regernative Medicine Research laboratory, Department of Zoology, University of Calcutta, West Bengal, India
  • Received: 31 August 2017 Accepted: 17 October 2017 Published: 25 October 2017

  • The role of free radicals can be found in the inflammatory process which is a complex process resulting many human diseases. Inflammations are mainly divided into acute and chronic inflammation depending on various inflammatory processes and cellular mechanisms. In recent years, there has been a great deal of attention to the field of free radical chemistry. Free radicals such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states. The purpose of the present review is to mention the role of free radical formation in the most common inflammatory processes in animals. Continued oxidative stress can lead to chronic inflammation, which in turn could mediate the most chronic diseases including cancer, diabetes, cardiovascular, neurological, and pulmonary diseases. ROS and RNS are well recognized for playing role as deleterious species. ROS and RNS are normally generated by tightly regulated enzymes, such as NO synthase (NOS) and NAD(P)H oxidase isoforms, respectively. The detrimental effect of free radicals causing health damages is termed oxidative stress and nitrosative stress. Overproduction of ROS results in oxidative stress, a deleterious process that can damage cell structures, including lipids, proteins, and DNA.

    Citation: Silpak Biswas, Rintu Das, Ena Ray Banerjee. Role of free radicals in human inflammatory diseases[J]. AIMS Biophysics, 2017, 4(4): 596-614. doi: 10.3934/biophy.2017.4.596

    Related Papers:

  • The role of free radicals can be found in the inflammatory process which is a complex process resulting many human diseases. Inflammations are mainly divided into acute and chronic inflammation depending on various inflammatory processes and cellular mechanisms. In recent years, there has been a great deal of attention to the field of free radical chemistry. Free radicals such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states. The purpose of the present review is to mention the role of free radical formation in the most common inflammatory processes in animals. Continued oxidative stress can lead to chronic inflammation, which in turn could mediate the most chronic diseases including cancer, diabetes, cardiovascular, neurological, and pulmonary diseases. ROS and RNS are well recognized for playing role as deleterious species. ROS and RNS are normally generated by tightly regulated enzymes, such as NO synthase (NOS) and NAD(P)H oxidase isoforms, respectively. The detrimental effect of free radicals causing health damages is termed oxidative stress and nitrosative stress. Overproduction of ROS results in oxidative stress, a deleterious process that can damage cell structures, including lipids, proteins, and DNA.


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    [1] Stohs SJ (1995) The role of free radicals in toxicity and disease. J Basic Clin Physiol Pharmacol 6: 205–228.
    [2] Florence TM (1995) The role of free radicals in disease. Aust N Z J Ophthalmol 23: 3–7. doi: 10.1111/j.1442-9071.1995.tb01638.x
    [3] Harrison D, Griendling KK, Landmesser U, et al. (2003) Role of oxidative stress in atherosclerosis. Am J Cardiol 91: 7A–11A.
    [4] Rahman T, Hosen I, Islam MMT, et al. (2012) Oxidative stress and human health. Adv Biosci Biot 3: 997–1019. doi: 10.4236/abb.2012.327123
    [5] Ríos-Arrabal S, Artacho-Cordón F, León J, et al. (2013) Involvement of free radicals in breast cancer. Springerplus 2: 404. doi: 10.1186/2193-1801-2-404
    [6] Cadenas E, Sies H (1998) The lag phase. Free Radic Res 28: 601–609. doi: 10.3109/10715769809065816
    [7] Kovacic P, Pozos RS, Somanathan R, et al. (2005) Mechanism of mitochondrial uncouplers, inhibitors, and toxins: Focus on electron transfer, free radicals, and structure-activity relationships. Curr Med Chem 12: 2601–2623. doi: 10.2174/092986705774370646
    [8] Valko M, Izakovic M, Mazur M, et al. (2004) Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem 266: 37–56. doi: 10.1023/B:MCBI.0000049134.69131.89
    [9] Phaniendra A, Jestadi DB, Periyasamy L (2015) Free radicals: properties, sources, targets, and their implication in various diseases. Ind J Clin Biochem 30: 11–26. doi: 10.1007/s12291-014-0446-0
    [10] Valko M, Morris H, Cronin MTD (2005) Metals, toxicity and oxidative stress. Curr Med Chem 12: 1161–1208. doi: 10.2174/0929867053764635
    [11] Poyton RO, Ball KA, Castello PR (2009) Mitochondrial generation of free radicals and hypoxic signaling. Trends Endocrin Met 20: 332–340. doi: 10.1016/j.tem.2009.04.001
    [12] Turrens JF (2003) Mitochondrial formation of reactive oxygen species. J Physiol 552: 335–344. doi: 10.1113/jphysiol.2003.049478
    [13] Sumbayev VV, Yasinska IM (2007) Mechanisms of hypoxic signal transduction regulated by reactive nitrogen species. Scand J Immunol 65: 399–406. doi: 10.1111/j.1365-3083.2007.01919.x
    [14] Reuter S, Gupta SC, Chaturvedi MM, et al. (2010) Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Bio Med 49: 1603–1616. doi: 10.1016/j.freeradbiomed.2010.09.006
    [15] Arulselvan P, Fard MT, Tan WS, et al. (2016) Role of Aantioxidants and natural products in inflammation. Oxid Med Cell Longev: 5276130.
    [16] Sun J, Trumpower BL (2003) Superoxide anion generation by the cytochrome bc1 complex. ArchBiochem Biophys 419: 198–206. doi: 10.1016/j.abb.2003.08.028
    [17] Henson P, Larsen G, Henson J, et al. (1984) Resolution of pulmonary inflammation. Fed Proc 43: 2799–2806.
    [18] Schmid-Schonbein GW (2006) Analysis of inflammation. Annu Rev Biomed Eng 8: 93–151. doi: 10.1146/annurev.bioeng.8.061505.095708
    [19] Markiewski MM, Lambris JD (2007) The role of complement in inflammatory diseases from behind the scenes into the spotlight. AM J Pathol 171: 715–727. doi: 10.2353/ajpath.2007.070166
    [20] Eaves-Pyles T, Allen CA, Taormina J, et al. (2008) Escherichia coli isolated from a Crohn's disease patient adheres, invades, and induces inflammatory responses in polarized intestinal epithelial cells. Int J MedMicrobiol 298: 397–409.
    [21] Ferguson LR (2010) Chronic inflammation and mutagenesis. Mutat Res 690: 3–11. doi: 10.1016/j.mrfmmm.2010.03.007
    [22] Weber A, Boege Y, Reisinger F, et al. (2011) Chronic liver inflammation and hepatocellular carcinoma: persistence matters. Swiss Med Wkly 141: w13197.
    [23] Gomberg M (1900) An incidence of trivalent carbon trimethylphenyl. J Am Chem Soc 22: 757–771. doi: 10.1021/ja02049a006
    [24] Gerschman R, Gilbert DL, Nye SW, et al. (1954) Oxygen poisoning and x-irradiation-A mechanism in common. Science 119: 623–626. doi: 10.1126/science.119.3097.623
    [25] Commoner B, Townsend J, Pake GE (1954) Free radicals in biological materials. Nature 174: 689–691.
    [26] McCord JM, Fridovich I (1969) Superoxide dismutase an enzymatic function for erythrocuprein (chemocuprein). J Biol Chem 244: 6049–6055.
    [27] Babior BM, Kipnes RS, Curnutte JT (1973) Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent. J Clin Invest 52: 741–744.
    [28] Babior BM, Curnutte JT, Kipnes RS (1975) Biological defense mechanisms. Evidence for the participation of superoxide in bacterial killing by xanthine oxidase. J Lab Clin Med 85: 235–244.
    [29] Hassett DJ, Britigan BE, Svendsen T, et al. (1987) Bacteria form intracellular free radicals in response to paraquat and streptonigrin. Demonstration of the potency of hydroxyl radical. J Biol Chem 262: 13404–13408.
    [30] Halliwell B, Gutteridge JMC (1989) Free radicals in biology and medicine, Clarendon Press.
    [31] Kohen R, Nyska A (2002) Invited review oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol Pathol 30: 620. doi: 10.1080/01926230290166724
    [32] Halliwell B (2001) Free Radicals and other reactive species in disease.
    [33] Mugoni V, Santoro MM (2013) Manipulating redox signaling to block tumor angiogenesis, research directions in tumor angiogenesis, Chai JY, Editor.
    [34] Valko M, Leibfritz D, Moncol J, et al. (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Bio 39: 44–84. doi: 10.1016/j.biocel.2006.07.001
    [35] Miller DM, Buettner GR, Aust SD (1990) Transition metals as catalysts of "autoxidation" reactions. Free Radic Bio Med 8: 95–108. doi: 10.1016/0891-5849(90)90148-C
    [36] Lushchak VI (2014) Classification of oxidative stress based on its intensity. Excli J 13: 922–937.
    [37] Nita M, Grzybowski A (2016) The role of the reactive oxygen species and oxidative stress in the pathomechanism of the age-related ocular diseases and other pathologies of the anterior and posterior eye segments in adults. Oxid Med Cell Longev 1–23.
    [38] Bagheri F, Khori V, Alizadeh AM, et al. (2016) Reactive oxygen species-mediated cardiac-reperfusion injury: Mechanisms and therapies. Life Sci 16: 30570–30577.
    [39] Lobo V, Patil A, Phatak A, et al. (2010) Free radicals, antioxidants and functional foods: impact on human health, Pharmacogn Rev 4: 118–126.
    [40] Inoue M, Sato EF, Nishikawa M, et al. (2003) Mitochondrial generation of reactive oxygen species and its role in aerobic life. Curr Med Chem 10: 2495. doi: 10.2174/0929867033456477
    [41] Tandon V, Gupta BM, Tandon R (2005) Free radicals/Reactive oxygen species. JK-Practioner 12: 143–148.
    [42] Bandyopadhyay U, Das D, Banerjee RK (1999) Reactive oxygen species: Oxidative damage and pathogenesis. Curr Sci 77: 658–665.
    [43] Ashok S, Jayashree G, Pankaja N (2012) Effect of free radicals & antioxidants on oxidative stress: a review. J D & A Sci 1: 63–66.
    [44] Dröse S, Brandt U (2012) Molecular mechanisms of superoxide production by the mitochondrial respiratory chain. Adv Exp Med Bio 748: 145–69. doi: 10.1007/978-1-4614-3573-0_6
    [45] Slater TF (1985) Free radical mechanism in tissue injury. J Biochem 222: 1–15.
    [46] Valko M, Rhodes CJ, Moncol J, et al. (2006) Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160: 1–40. doi: 10.1016/j.cbi.2005.12.009
    [47] Sies H (1997) Oxidative stress: Oxidants and antioxidants. Exp Physiol 82: 291. doi: 10.1113/expphysiol.1997.sp004024
    [48] Simon HU, Haj-Yehia A, Levi-Schaffer F (2000) Role of reactive oxygen species (ROS) in the apoptosis induction. Apoptosis 5: 415. doi: 10.1023/A:1009616228304
    [49] Halliwell B, Murcia MA, Chirico S, et al. (1995) Free radicals and antioxidants in food and in vivo: what they do and how they work. Crit Rev Food Sci Nutr 35: 7–20. doi: 10.1080/10408399509527682
    [50] Young IS, Woodside JV (2001) Antioxidants in health and disease. J Clin Pathol 54: 176–186. doi: 10.1136/jcp.54.3.176
    [51] Sisein EA (2014) Biochemistry of free radicals and antioxidants. Sch Acad J Biosci 2: 110–118.
    [52] Shetti N, Patil R (2011) Antioxidants: Its beneficial role against health damaging free radical. World J Sci Technol 1: 46–51. doi: 10.4236/wjnst.2011.12008
    [53] Katakwar P, Metgud R, Naik S, et al. (2016) Oxidative stress marker in oral cancer: a review. J Can Res Ther 12: 438–446. doi: 10.4103/0973-1482.151935
    [54] Hayyan M, Hashim MA, AlNashef IM (2016) Superoxide Ion: Generation and Chemical Implications. Chem Rev 116: 3029–3085. doi: 10.1021/acs.chemrev.5b00407
    [55] Michelson AM, McCord JM, Fridovich I (1977) Superoxide and Superoxide Dismutases. London: Academic Press, 320.
    [56] Afanas'ev I (2015) Mechanisms of superoxide signaling in epigenetic processes: relation to aging and cancer, aging and disease. Aging Dis 6: 216–227. doi: 10.14336/AD.2014.0924
    [57] Ardan T, Kovaceva J, Cejková J (2004) Comparative histochemical and immunohistochemical study on xanthine oxidoreductase/xanthine oxidase in mammalian corneal epithelium. Acta Histochemica 106: 69–75. doi: 10.1016/j.acthis.2003.08.001
    [58] Muller FL, Lustgarten MS, Jang Y, et al. (2007) Trends in oxidative aging theories. Free Radic. Biol. Med 43: 477–503. doi: 10.1016/j.freeradbiomed.2007.03.034
    [59] Kontos HA, Wei EP, Ellis EF, et al. (1985) Appearance of superoxide anion radical in cerebral extracellular space during increased prostaglandin synthesis in cats. Circ Res 57: 142–151. doi: 10.1161/01.RES.57.1.142
    [60] McIntyre M, Bohr DF, Dominiczak AF (1999) Endothelial function in hypertension. Hypertension 34: 539–545. doi: 10.1161/01.HYP.34.4.539
    [61] Roy P, Roy SK, Mitra A, et al. (1994) Superoxide generation by lipoxygenase in the presence of NADH and NADPH. Biochim. Biophys. Acta 1214: 171–179.
    [62] Montezano AC, Touyz RM (2014) Reactive oxygen species, vascular noxs, and hypertension: focus on translational and clinical research. Antioxid Redox Sig 20: 164–182. doi: 10.1089/ars.2013.5302
    [63] Marchi KC, Ceron CS, Muniz JJ (2016) NADPH oxidase plays a role on ethanol-Induced hypertension and Reactive Oxygen Species generation in the vasculature. Alcohol Alcoholism 51: 522–534. doi: 10.1093/alcalc/agw043
    [64] Bielski BHJ, Cabelli DE (1996) Superoxide and hydroxyl radical chemistry in aqueous solution. A Oxy Chem: 66–104.
    [65] De Grey AD (2002) HO2*: the forgotten radical. DNA Cell Biol 21: 251-257. doi: 10.1089/104454902753759672
    [66] Cerruti PA (1985) Pro-oxidant states and tumor activation. Science 227: 375–381. doi: 10.1126/science.2981433
    [67] Kelley EE, Khoo NK, Hundley NJ et al. (2010) Hydrogen peroxide is the major oxidant product of xanthine oxidase. Free Radic Biol Med 48: 493–498. doi: 10.1016/j.freeradbiomed.2009.11.012
    [68] Chance B, Sies H, Boveris A (1979) Hydroperoxide metabolism in mammalian organs. Physiol Rev 59: 527–605.
    [69] Halliwell B, Clement MV, Long LH (2000) Hydrogen peroxide in the human body. FEBS Lett 486: 10–3. doi: 10.1016/S0014-5793(00)02197-9
    [70] Fisher AE, Maxwell SC, Naughton DP (2004) Superoxide and hydrogen peroxide suppression by metal ions and their EDTA complexes. Biochem Biophys Res Commun. 316: 48-51. doi: 10.1016/j.bbrc.2004.02.013
    [71] Mates JM, Perez-Gomez C, Nunez de Castro I (1999) Antioxidant enzymes and human diseases. Clin Biochem 32: 595–603. doi: 10.1016/S0009-9120(99)00075-2
    [72] Chae HZ, Kang SW, Rhee SG (1999) Isoforms of mammalian peroxiredoxin that reduce peroxides in presence of thioredoxin. Meth Enzymol 300: 219–226. doi: 10.1016/S0076-6879(99)00128-7
    [73] Halliwell B, Gutteridge JMC (1999) Free radicals in biology and medicine, 3 Eds., Oxford University Press, 1–936.
    [74] Dirmeier R, O'Brien K, Engle M, et al. (2004) Measurement of oxidative stress in cells exposed to hypoxia and other changes in oxygen concentration. Meth Enzymol 381: 589–603. doi: 10.1016/S0076-6879(04)81038-3
    [75] Stadtman ER (2004) Role of oxidant species in aging. Curr Med Chem 11: 1105–1112. doi: 10.2174/0929867043365341
    [76] Uchida K (2003) 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog Lipid Res 42: 318–343. doi: 10.1016/S0163-7827(03)00014-6
    [77] Maxwell SRJ, Lip GYH (1997) Free radicals and antioxidants in cardiovascular disease. Brit J Clin Pharmaco 44: 307–317.
    [78] Menotti A, Kromhout D, Blackburn H, et al. (1999) Food intake patterns and 25 year mortality from coronary heart disease: cross-cultural correlations in the Seven Countries Study. Eur J Epidemiol 15: 507–515.
    [79] Lim SS, Vos T, Flaxman AD, et al. (2012) A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380: 2224–2260. doi: 10.1016/S0140-6736(12)61766-8
    [80] Heron M (2013) Deaths: leading causes for 2010. Natl Vital Stat Rep 62: 1–96.
    [81] Kadhum M, Sweidan A, Jaffery AE, et al. (2015) A review of the health effects of smoking shisha. Clin Med 15: 263–266. doi: 10.7861/clinmedicine.15-3-263
    [82] Morris PB, Ference BA, Jahangir E, et al. (2015) Cardiovascular effects of exposure to cigarette smoke and electronic cigarettes: clinical perspectives from the prevention of cardiovascular disease section leadership council and early career councils of the American college of cardiology. J Am Col Cardiol 66: 1378–1391. doi: 10.1016/j.jacc.2015.07.037
    [83] Jensen IJ, Mæhre HK (2016) Preclinical and clinical studies on antioxidative, antihypertensive and cardioprotective effect of marine proteins and peptides-a review. Mar Drugs14: 211.
    [84] Reid MB (2001) Redox modulation of skeletal muscle contraction: what we know and what we don't. Brit J Radiol 90: 724–731.
    [85] Kukreja RC, Hess ML (1992) The oxygen free-radical system-From equations through membrane–protein interactions to cardiovascular injury and protection. Cardiovasc Res 26: 641–655. doi: 10.1093/cvr/26.7.641
    [86] Panth N, Paudel KR, Parajuli K (2016) Reactive oxygen species: a key hallmark of cardiovascular disease. Adv Med: 1–12.
    [87] Sverdlov AL, Elezaby A, Behring JB, et al. (2015) High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II. J Mol Cell Cardiol 78: 165–173.
    [88] Santos CX, Anilkumar N, Zhang M, et al. (2011) Redox signaling in cardiac myocytes. Free Radic Biol Med 50: 777–793.
    [89] Ku HJ, Ahn Y, Lee JH (2015) IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice. Free Radic Biol Med 80: 84–92.
    [90] Sverdlov AL, Elezaby A, Qin F, et al. (2016) Mitochondrial reactive oxygen species mediate cardiac structural, functional, and mitochondrial consequences of diet‐induced metabolic heart disease. J Am Heart Assoc 5: e002555. doi: 10.1161/JAHA.115.002555
    [91] Zhang YB, Meng YH, Chang S, et al. (2016) High fructose causes cardiac hypertrophy via mitochondrial signaling pathway. Am J Transl Res 8: 4869–4880.
    [92] Mellor K, Ritchie RH, Meredith G, et al. (2010) High-fructose diet elevates myocardial superoxide generation in mice in the absence of cardiac hypertrophy. Nutrition 26: 842–848.
    [93] Mellor K, Ritchie R, Morris M, et al. (2016) Elevated myocardial superoxide production precedes the cardiac hypertrophy response to a high fructose diet in mice. Am J Physiol Renal Physiol 310: 547–559.
    [94] Pryor WA, Stone K (1993) Oxidants in cigarette smoke. Radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite. Ann N Y Acad Sci 686: 12–27.
    [95] Barnoya J, Glantz SA (2005) Cardiovascular effects of secondhand smoke: nearly as large as smoking. Circulation 111: 2684–2698. doi: 10.1161/CIRCULATIONAHA.104.492215
    [96] Jaffa MA, KobeissyF, Al Hariri M et al. (2012) Global renal gene expression profiling analysis in B2-kinin receptor null mice: impact of diabetes. PloS One7: e44714.
    [97] Al Hariri M, Zibara K, Farhat W, et al. (2016) Cigarette smoking-induced cardiac hypertrophy, vascular inflammation and injury are attenuated by antioxidant supplementation in an animal model. Front Pharmacol 7: 397.
    [98] He F, Zuo L (2015) Redox roles of reactive oxygen species in cardiovascular diseases. Int J Mol Sci 16: 27770–27780. doi: 10.3390/ijms161126059
    [99] Maritim A, Dene BA, Sanders RA, et al. (2003) Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17: 193–199. doi: 10.1002/jbt.10078
    [100] Movahedian A, Zolfaghari B, Sajjadi SE, et al. (2010) Antihyperlipidemic effect of Peucedanum pastinacifolium extract in streptozotocin-induced diabetic rats. Clinics (Sao Paulo) 65: 629–933.
    [101] Iravani S, Zolfaghari B (2011) Pharmaceutical and nutraceutical effects of Pinus pinaster bark extract. Res Pharm Sci 6: 1–11.
    [102] Golbidi S, Badran M, Laher I (2012) Antioxidant and anti-inflammatory effects of exercise in diabetic patients. Exp Diabetes Res: 1–16.
    [103] Schönlau F, Rohdewald P (2001) Pycnogenol for diabetic retinopathy. A review. Int Ophthalmol 24: 161–171.
    [104] Voutilainen S, Nurmi T, Mursu J, et al. (2006) Carotenoids and cardiovascular health. Am J Clin Nutr 83: 1265–1271.
    [105] Bashan N, Kovsan J, Kachko I (2009) Positive and negative regulation of insulin signaling by reactive oxygen and nitrogen species. Physiol Rev 89: 27–71.
    [106] Kangralkar VA, Patil SD, Bandivadekar RM (2010) Oxidative stress and diabetes: a review. Int J Pharm Appl 1: 38–45.
    [107] Asmat U, Abad K, Ismail K (2016) Diabetes mellitus and oxidative stress-A concise review. Saudi Pharm J 24: 547–553. doi: 10.1016/j.jsps.2015.03.013
    [108] Rolo AP, Palmeira CM (2006) Diabetes and mitochondrial function: Role of hyperglycemia and oxidative stress. Toxicol Appl Pharmacol 212: 167–178.
    [109] Haidara MA, Yassin HZ, Rateb M, et al. (2006) Role of oxidative stress in development of cardiovascular complications in diabetes mellitus. Curr Vasc Pharmacol 4: 215–227. doi: 10.2174/157016106777698469
    [110] Bajaj S, Khan A (2012) Antioxidants and diabetes. Indian J Endocrinol Metab 16: S267–S271.
    [111] Aghadavod E, Khodadadi S, Baradaran A, et al. (2016) role of oxidative stress and inflammatory factors in diabetic kidney disease. Iran J Kidney Dis 10: 337–343.
    [112] Perez-Gutierrez RM, Garcia-Campoy AH, Muñiz-Ramirez A (2016) Properties of flavonoids isolated from the bark of Eysenhardtia polystachya and their effect on oxidative stress in streptozotocin-induced diabetes mellitus in mice. Oxid Med Cell Longev 9156510.
    [113] Elgazzar MA (2007) Thymoquinone suppresses in vitro production of IL-5 and IL-13 by mast cells in response to lipopolysaccharide stimulation.Inflamm Res56:345–351.
    [114] Golbidi S, Laher I (2010) Antioxidant therapy in human endocrine disorders.Med Sci Monitor16:9–24.
    [115] Blumberg RS, Strober W (2001) Prospects for research in inflammatory bowel disease. JAMA-J Am Med Assoc 285: 643–647. doi: 10.1001/jama.285.5.643
    [116] Das R, Trafadar B, Das P, et al. (2015) Anti-inflammatory and regenerative potential of probiotics to combat inflammatory bowel disease (IBD). J Biotechnol Biomater 5: 181.
    [117] Gross V, Arndt H, Andus T, et al. (1994) Free radicals in inflammatory bowel diseases pathophysiology and therapeutic implications. Hepatogastroenterology 41: 320–327.
    [118] Fang J, Yin H, Liao L, et al. (2016) Water soluble PEG-conjugate of xanthine oxidase inhibitor, PEG-AHPP micelles, as a novel therapeutic for ROS related inflammatory bowel diseases. J Control Release 10: 188–196.
    [119] Narushima S, Spitz DR, Oberley LW, et al. (2003) Evidence for oxidative stress in NSAID-induced colitis in IL10 mice. Free Radic Biol Med 34: 1153–1166.
    [120] Keshavarzian A, Banan A, Farhadi A, et al. (2003) Increases in free radicals and cytoskeletal protein oxidation and nitration in the colon of patients with inflammatory bowel disease. Gut 52: 720–728. doi: 10.1136/gut.52.5.720
    [121] Patel MA, Patel PK, Patel MB (2010) Effects of ethanol extract of Ficus bengalensis (bark) on inflammatory bowel disease. Indian J Pharmacol 42: 214–218.
    [122] Moret-Tatay I, Iborra M, Cerrillo E, et al. (2016) Possible biomarkers in blood for crohn's disease: oxidative stress and micrornas-current evidences and further aspects to unravel. Oxid Med Cell Longev 2325162.
    [123] Abraham C, Medzhitov R (2011) Interactions between the host innate immune system and microbes in inflammatory bowel disease. Gastroenterology 140: 1729–1737. doi: 10.1053/j.gastro.2011.02.012
    [124] Cross RK, Wilson KT (2003) Nitric oxide in inflammatory bowel disease. Inflamm Bowel Dis 9: 179–189. doi: 10.1097/00054725-200305000-00006
    [125] Kimura H, Hokari R, Miura S, et al. (1998) Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis. Gut 42: 180–187. doi: 10.1136/gut.42.2.180
    [126] Rachmilewitz D, Eliakim R, Ackerman Z, et al. (1998) Direct determination of colonic nitric oxide level-a sensitive marker of disease activity in ulcerative colitis. Am J Gastroenterol 93: 409–412.
    [127] Avdagić N, Zaćiragić A, Babić N, et al. (2013) Nitric oxide as a potential biomarker in inflammatory bowel disease. Bosn J Basic Med Sci 13: 5–9. doi: 10.17305/bjbms.2013.2402
    [128] Soufli I, Toumi R, Rafa H, et al. (2016) Overview of cytokines and nitric oxide involvement in immuno-pathogenesis of inflammatory bowel diseases. World J Gastrointest Pharmacol Ther 7: 353–360. doi: 10.4292/wjgpt.v7.i3.353
    [129] Fatani AJ, Alrojayee FS, Parmar MY, et al. (2016) Myrrh attenuates oxidative and inflammatory processes in acetic acid-induced ulcerative colitis. Exp Ther Med 12: 730–738. doi: 10.3892/etm.2016.3398
    [130] Liu YW, Ong WK, Su YW, et al. (2016) Anti-inflammatory effects of Lactobacillus brevis K65 on RAW 264.7 cells and in mice with dextran sulphate sodium-induced ulcerative colitis. Benef Microbes 7: 387–396.
    [131] Kottova M, Pourova J, Voprsalova M (2007) Oxidative stress and its role in respiratory diseases. Ceska Slov Farm 56: 215–219.
    [132] Zinellu A, Fois AG, Sotgia S, et al. (2016) Plasma protein thiols: an early marker of oxidative stress in asthma and chronic obstructive pulmonary disease. Eur J Clin Invest 46: 181–188. doi: 10.1111/eci.12582
    [133] Masoli M, Fabian D, Holt S, et al. (2004) The global burden of asthma: Executive summary of the GINA Dissemination Committee report. Allergy 59: 469–478. doi: 10.1111/j.1398-9995.2004.00526.x
    [134] Lemanske RF, Busse WW (2010) Asthma: Clinical Expression and Molecular Mechanisms. J Allergy Clin Immun 125: S95–S102. doi: 10.1016/j.jaci.2009.10.047
    [135] Chung KF (1986) Role of inflammation in the hyper reactivity of the airways in asthma. Thorax 41: 657–662. doi: 10.1136/thx.41.9.657
    [136] Barnes PJ (1990) Reactive oxygen species and airway inflammation. Free Rad Biol Med 9: 235–243. doi: 10.1016/0891-5849(90)90034-G
    [137] Doelman CJA, Bast A (1990) Oxygen radicals in lung pathology. Free Rad Biol Med 9: 381–400. doi: 10.1016/0891-5849(90)90015-B
    [138] Wood LG, Gibson LG, Garg ML (2003) Biomarkers of lipid peroxidation, airway inflammation and asthma. Eur Respir J 21: 177–186. doi: 10.1183/09031936.03.00017003a
    [139] Terada LS (2006) Specificity in reactive oxidant signaling: Think globally, act locally. J Cell Biol 174: 615–623. doi: 10.1083/jcb.200605036
    [140] Biagioli MC, Kaul P, Singh I, et al. (1999) The role of oxidative stress in rhinovirus induced elaboration of IL‐8 by respiratory epithelial cells. Free Rad Biol Med 26: 454–462. doi: 10.1016/S0891-5849(98)00233-0
    [141] Kanazawa H, Kurihara N, Hirata K, et al. (1991) The role of free radicals in airway obstruction in asthmatic patients. Chest 100: 1319–1322. doi: 10.1378/chest.100.5.1319
    [142] Shanmugasundaram KR, Kumar SS, Rajajee S (2001) Excessive free radical generation in the blood of children suffering from asthma. Clin Chim Acta 305: 107–114. doi: 10.1016/S0009-8981(00)00425-3
    [143] Rahman I, Biswas SK, Kode A (2006) Oxidant and antioxidant balance in the airways and airway diseases. Eur J Pharmacol 533: 222–239. doi: 10.1016/j.ejphar.2005.12.087
    [144] Pobed'onna HP (2005) Antioxidant protection, metabolites of nitrogen oxide on the forming of oxidative stress in patients with bronchial asthma. Lik Sprava: 36–40.
    [145] Rahman I, Morrison D, Donaldson K, et al. (1996) Systemic oxidative stress in asthma, COPD and smokers. Am J Respir Crit Care Med 154: 1055–1060.
    [146] Muti AD, Pârvu AE, Muti LA, et al. (2016) Vitamin E effect in a rat model of toluene diisocyanate-induced asthma. Clujul Mel 89: 499–505. doi: 10.15386/cjmed-611
    [147] Sahiner UM, Birben E, Erzurum S et al. (2011) Oxidative stress in asthma. World Allergy Organ J 4: 151–158. doi: 10.1097/WOX.0b013e318232389e
    [148] Tohyama Y, Kanazawa H, Fujiwara F, et al. (2005) Role of nitric oxide on airway microvascular permeability in patients with asthma. Osaka City Med J 51: 1–9.
    [149] Wedes SH, Khatri SB, Zhang R, et al. (2009) Noninvasive markers of airway inflammation in asthma. Clin Transl Sci 2: 112–117. doi: 10.1111/j.1752-8062.2009.00095.x
    [150] Sanders SP (1999) Nitric oxide in asthma. Pathogenic, therapeutic, or diagnostic? Am J Respir CellMol Biol 21: 147–149.
    [151] Edwards CRW, Bouchier IAD, (1994) Davidson's Principles and Practice of Medicine. Chirchill Livingstone UK. 16 Eds.
    [152] Kundu S, Ghosh P, Datta S, et al. (2012) Oxidative stress as a potential biomarker for determining disease activity in patients with rheumatoid arthritis. Free Radic Res 46: 1482–1489. doi: 10.3109/10715762.2012.727991
    [153] Feely MG, Erickson A, O'Dell JR (2009) Therapeutic options for rheumatoid arthritis. Expert Opin Pharmacother 10: 2095. doi: 10.1517/14656560903071043
    [154] Bala A, Haldar PK (2013) Free radical biology in cellular inflammation related to rheumatoid arthritis. OA Arthritis 1: 15.
    [155] Mason AD, McManus AT, Pruitt BA (1986) Association of burn mortality and bacteraemia: A 25-year review. Arch Surg 121: 1027–1031. doi: 10.1001/archsurg.1986.01400090057009
    [156] Al-Jawad FH, Sahib AS, Al-Kaisy AA (2008) Role of antioxidants in the treatment of burn lesions. Ann Burns Fire Disasters 21: 186–191.
    [157] Ipaktchi K, Mattar A, Niederbichler AD, et al. (2006) Attenuating burn wound inflammatory signaling reduces systemic inflammation and acute lung injury. J Immunol. 177: 8065–8071. doi: 10.4049/jimmunol.177.11.8065
    [158] Sehirli O, Sener E, Sener G, et al. (2008) Ghrelin improves burn-induced multiple organ injury by depressing neutrophil infiltration and the release of pro-inflammatory cytokines. Peptides 29: 1231–1240. doi: 10.1016/j.peptides.2008.02.012
    [159] Horton JW, White DJ (1995) Role of xanthine oxidase and leukocytes in post-burn cardiac dysfunction. J Am Coll Surg 181: 129–137.
    [160] Saitoh D, Okada Y, Ookawara T, et al. (1994) Prevention of ongoing lipid peroxidation by wound excision and superoxide dismutase treatment in the burned rat. Am J Emerg Med 12: 142–146. doi: 10.1016/0735-6757(94)90233-X
    [161] Piccolo MT, Wang Y, Till GO (1999) Chemotactic mediator requirements in lung injury following skin burns in rats. Exp Mol Pathol 66: 220–226. doi: 10.1006/exmp.1999.2263
    [162] Hosnuter M, Gurel A, Babuccu O, et al. (2004) The effect of CAPE on lipid peroxidation and nitric oxide levels in the plasma of rats following thermal injury. Burns 30: 121–125. doi: 10.1016/j.burns.2003.09.022
    [163] Singh V, Devgan L, Bhat S, et al. (2007) The pathogenesis of burn wound conversion. Ann Plast Surg 59: 109–115. doi: 10.1097/01.sap.0000252065.90759.e6
    [164] Rani M, Martin G, Schwacha MG (2012) Aging and the pathogenic response to burn. Aging Dis 3: 23–25.
    [165] Saez JC, Ward PH, Gunther B, et al. (1984) Superoxide radical involvement in the pathogenesis of burn shock. Circ Shock 12: 229–239.
    [166] Ward PA, Till GO, Hatherill JR, et al. (1985) Systemic complement activation, lung injury, and products of lipid peroxidation. J Clin Invest 76: 517–527. doi: 10.1172/JCI112001
    [167] Oldham KT, Guice KS, Till GO, et al. (1998) Activation of complement by hydroxyl radical in thermal injury. Surgery 104: 272–279.
    [168] Parihar A, Parihar MS, Milner S, et al. (2008) Oxidative stress and anti-oxidative mobilization in burn injury. Burns 34: 6–17. doi: 10.1016/j.burns.2007.04.009
    [169] Nielson CB, Duethman NC, Howard JM, et al. (2017) Burns: pathophysiology of systemic complications and current management. J Burn Care Res 38: e469–e481. doi: 10.1097/BCR.0000000000000355
    [170] Burton LK, Velasco SE, Patt A, et al. (1995) Xanthine oxidase contributes to lung leak in rats subjected to skin burn. Inflammation 19: 31–38. doi: 10.1007/BF01534378
    [171] Trachootham D, Alexandre J, Huang P (2009) Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 8: 579–591. doi: 10.1038/nrd2803
    [172] Pourahmad J, Salimi A, Seydi E (2016) Role of oxygen free radicals in cancer development and treatment, free radicals and diseases.
    [173] Ojo OA, Ajiboye B, Fadaka A, et al. (2017) nrf2-keap1 activation, a promising strategy in the prevention of cancer. Free Radic Antioxid 7: 1–7.
    [174] Asano H, Horinouchi T, Mai Y, et al. (2012) Nicotine- and tar-free cigarette smoke induces cell damage through reactive oxygen species newly generated by PKC-dependent activation of NADPH oxidase. J Pharmacol Sci 118: 275–287. doi: 10.1254/jphs.11166FP
    [175] Rai S, Malik R, Misra D, et al. (2014) Future prospective and current status of antioxidants in premalignant and malignant lesions of oral cavity. Int J Nutr Pharmacol Neurol Dis 4: 198–202. doi: 10.4103/2231-0738.139399
    [176] Weatherall D, Akinyanju O, Fucharoen S, et al. (2006) In disease control priorities in developing countries, In: Jamison DT, Breman JG, Measham AR, et al., Editors, Inherited Disorders of Hemoglobin. Washington: World Bank.
    [177] Nisbet RM, Polanco J, Ittner LM, et al. (2015) Tau aggregation and its interplay with amyloid-β. Acta Neuropathol 129: 207–220. doi: 10.1007/s00401-014-1371-2
    [178] Bolós M, Perea R, Avila J (2017) Alzheimer's disease as an inflammatory disease. Bio Mol Concepts: 1–7.
    [179] Murphy MP (2009) How mitochondria produce reactive oxygen species. Biochem J 417: 1–13. doi: 10.1042/BJ20081386
    [180] Olajide OJ, Yawson EO, Gbadamosi IT, et al. (2017) Ascorbic acid ameliorates behavioural deficits and neuropathologicalalterations in rat model of Alzheimer's disease. Environ Toxicol Phar 50: 200–211. doi: 10.1016/j.etap.2017.02.010
    [181] Kovacic P, Jacintho JD (2001) Mechanisms of carcinogenesis: Focus on oxidative stress and electron transfer. Curr Med Chem 8: 773–796. doi: 10.2174/0929867013373084
    [182] Ridnour LA, Isenberg JS, Espey MG, et al. (2005) Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1. Proc Natl Acad Sci USA 102: 13147–13152. doi: 10.1073/pnas.0502979102
    [183] Valko M, Morris H, Mazur M, et al. (2001) Oxygen free radical generating mechanisms in the colon: Do the semiquinones of Vitamin K play a role in the aetiology of colon cancer? Biochim Biophys Acta 1527: 161–166. doi: 10.1016/S0304-4165(01)00163-5
    [184] Pham-Huy LA, He H, Pham-Huy C (2008) Free radicals, antioxidants in disease and health. Int J Biomed Sci 4: 89–96.
    [185] Cadenas E (1997) Basic mechanisms of antioxidant activity. Biofactors 6: 391–397. doi: 10.1002/biof.5520060404
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