Beneficial Role of Coffee and Caffeine in Neurodegenerative Diseases: A Minireview

Yenisetti SC; Muralidhara; Yenisetti SC; Muralidhara

doi:10.3934/publichealth.2016.2.407

AIMS Public Health

2016, Volume 3, Issue 2: 407-422. doi: 10.3934/publichealth.2016.2.407

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Beneficial Role of Coffee and Caffeine in Neurodegenerative Diseases: A Minireview

Yenisetti SC ¹,
Muralidhara ^{1,2
,
,}

1.
Drosophila Neurobiology laboratory, Department of Zoology, Nagaland University (Central), Lumami, 798627, Nagaland, India
2.
Department of Biochemistry & Nutrition, CSIR-CFTRI , Mysore, 570020

Received: 26 March 2016 Accepted: 13 June 2016 Published: 20 June 2016

Coffee is among the most widespread and healthiest beverages in the world. Coffee typically contains more caffeine than most other beverages, and is widely and frequently consumed. Thus, it contributes significantly to the overall caffeine consumption within the general population, particularly in adults. Controversies regarding its benefits and risks still exist as reliable evidence is becoming available supporting its health-promoting potential. Several lines of evidence have highlighted the beneficial effects towards several disease conditions including Type II diabetes, hepatitis C virus, hepatocellular carcinoma, nonalcoholic fatty liver disease and neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic Lateral Sclerosis (ALS). The health-promoting properties of coffee are largely attributed to its rich phytochemistry, including caffeine, chlorogenic acid, caffeic acid, and hydroxy hydroquinone. In this minireview, an attempt has been made to discuss the various evidences which are mainly derived from animal and cell models. Various mechanisms chiefly responsible for the beneficial effects of caffeine have also been briefly outlined. A short note on the undesirable effects of excessive coffee intakes is also presented.
- Coffee,
- caffeine,
- Neuroproective effects,
- animal/cell,
- models
Citation: Yenisetti SC, Muralidhara. Beneficial Role of Coffee and Caffeine in Neurodegenerative Diseases: A Minireview[J]. AIMS Public Health, 2016, 3(2): 407-422. doi: 10.3934/publichealth.2016.2.407

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Abstract

Coffee is among the most widespread and healthiest beverages in the world. Coffee typically contains more caffeine than most other beverages, and is widely and frequently consumed. Thus, it contributes significantly to the overall caffeine consumption within the general population, particularly in adults. Controversies regarding its benefits and risks still exist as reliable evidence is becoming available supporting its health-promoting potential. Several lines of evidence have highlighted the beneficial effects towards several disease conditions including Type II diabetes, hepatitis C virus, hepatocellular carcinoma, nonalcoholic fatty liver disease and neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic Lateral Sclerosis (ALS). The health-promoting properties of coffee are largely attributed to its rich phytochemistry, including caffeine, chlorogenic acid, caffeic acid, and hydroxy hydroquinone. In this minireview, an attempt has been made to discuss the various evidences which are mainly derived from animal and cell models. Various mechanisms chiefly responsible for the beneficial effects of caffeine have also been briefly outlined. A short note on the undesirable effects of excessive coffee intakes is also presented.

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