Modeling environmental transmission of MAP infection in dairy cows

  • Received: 20 March 2016 Accepted: 31 January 2017 Published: 01 August 2017
  • MSC : Primary: 92B05; Secondary: 34B15

  • Johne's disease is caused by Mycobacterium avium subspecies paratuberculosis(MAP). It is a chronic, progressive, and inflammatory disease which has a long incubation period. One main problem with the disease is the reduction of milk production in infected dairy cows. In our study we develop a system of ordinary differential equations to describe the dynamics of MAP infection in a dairy farm. This model includes the progression of the disease and the age structure of the cows. To investigate the effect of persistence of this bacteria on the farm on transmission in our model, we include environmental compartments, representing the pathogen input in an explicit way. The effect of indirect transmission from the bacteria in the environment and the culling of high-shedding adults can be seen in the numerical simulations. Since culling usually only happens once a year, we include a novel feature in the simulations with a discrete action of removing high-shedding adults once a year. We conclude that with culling of high shedders even at a high rate, the infection will persist in the modeled farm setting.

    Citation: Kokum R. De Silva, Shigetoshi Eda, Suzanne Lenhart. Modeling environmental transmission of MAP infection in dairy cows[J]. Mathematical Biosciences and Engineering, 2017, 14(4): 1001-1017. doi: 10.3934/mbe.2017052

    Related Papers:

  • Johne's disease is caused by Mycobacterium avium subspecies paratuberculosis(MAP). It is a chronic, progressive, and inflammatory disease which has a long incubation period. One main problem with the disease is the reduction of milk production in infected dairy cows. In our study we develop a system of ordinary differential equations to describe the dynamics of MAP infection in a dairy farm. This model includes the progression of the disease and the age structure of the cows. To investigate the effect of persistence of this bacteria on the farm on transmission in our model, we include environmental compartments, representing the pathogen input in an explicit way. The effect of indirect transmission from the bacteria in the environment and the culling of high-shedding adults can be seen in the numerical simulations. Since culling usually only happens once a year, we include a novel feature in the simulations with a discrete action of removing high-shedding adults once a year. We conclude that with culling of high shedders even at a high rate, the infection will persist in the modeled farm setting.


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    [1] [ D. J. Begg,R. J. Whittington, Experimental animal infection models for Johne's disease, an infectious enteropathy caused by Mycobacterium avium subsp. paratuberculosis, The Veterinary Journal, 176 (2008): 129-145.
    [2] [ R. Breban, Role of environmental persistence in pathogen transmission: A mathematical modeling approach, Journal of Mathematical Biology, 66 (2013): 535-546.
    [3] [ K. L. Cook,J. S. Britt,C. H. Bolster, Survival of Mycobacterium avium subsp. paratuberculosis in biofilms on livestock watering trough materials, Veterinary Microbiology, 141 (2010): 103-109.
    [4] [ O. Diekmann, H. Heesterbeek and T. Britton, Mathematical Tools for Understanding Infectious Disease Dynanics Princeton University Press, 2013.
    [5] [ O. Diekmann,J. A. P. Heesterbeek,M. G. Roberts, The construction of next-generation matrices for compartmental epidemic models, Journal of the Royal Society Interface, 7 (2010): 873-885.
    [6] [ E. Doré,J. Paré,G. Côté,S. Buczinski,O. Labrecque,J. P. Roy,G. Fecteau, Risk factors associated with transmission of Mycobacterium avium subsp. paratuberculosis to calves within dairy herd: A systematic review, Journal of Veterinary Internal Medicine, 26 (2012): 32-45.
    [7] [ P. van den Driessche,J. Watmough, Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission, Mathematical Biosciences, 180 (2002): 29-48.
    [8] [ P. van den Driessche,J. Watmough, Further notes on the basic reproduction number, Mathematical Epidemiology, 1945 (2008): 159-178.
    [9] [ L. A. Espejo,S. Godden,W. L. Hartmann,S. J. Wells, Reduction in incidence of Johne's disease associated with implementation of a disease control program in Minnesota demonstration herds, Journal of Dairy Science, 95 (2012): 4141-4152.
    [10] [ A. B. Garcia,L. Shalloo, Invited review: The economic impact and control of paratuberculosis in cattle, Journal of Dairy Science, 98 (2015): 5019-5039.
    [11] [ I. A. Gardner,S. S. Nielsen,R. J. Whittington,M. T. Collins,D. Bakker,B. Harris,S. Sreevatsan,J. E. Lombard,R. Sweeney,D. R. Smith,J. Gavalchin,S. Eda, Consensus-based reporting standards for diagnostic test accuracy studies for paratuberculosis in ruminants, Preventive Veterinary Medicine, 101 (2011): 18-34.
    [12] [ G. F. Gerlach, Paratuberculosis: the pathogen and routes of infection, Dtsch Tierarztl Wochenschr, 109 (2002): 504-506.
    [13] [ R. W. Humphry,A. W. Stott,C. Adams,G. J. Gunn, A model of the relationship between the epidemiology of Johne's disease and the environment in suckler-beef herds, The Veterinary Journal, 172 (2006): 432-445.
    [14] [ Z. Lu,R. M. Mitchell,R. L. Smith,J. S. Van Kessel,P. P. Chapagain,Y. H. Schukken,Y. T. Gröhn, The importance of culling in Johne's disease control, Journal of Theoretical Biology, 254 (2008): 135-146.
    [15] [ C. Marcé,P. Ezanno,M. F. Weber,H. Seegers,D. U. Pfeiffer,C. Fourichon, Invited review: Modeling within-herd transmission of Mycobacterium avium subspecies paratuberculosis in dairy cattle: A review, Journal of Dairy Science, 93 (2010): 4455-4470.
    [16] [ C. Marcé,P. Ezanno,H. Seegers,D. U. Pfeiffer,C. Fourichon, Predicting fadeout versus persistence of paratuberculosis in a dairy cattle herd for management and control purposes: a modelling study, Preventive Veterinary Medicine, 42 (2011): p36.
    [17] [ C. Marcé,P. Ezanno,H. Seegers,D. U. Pfeiffer,C. Fourichon, Within-herd contact structure and transmission of Mycobacterium avium subspecies paratuberculosis in a persistently infected dairy cattle herd, Preventive Veterinary Medicine, 100 (2011): 116-125.
    [18] [ T. Massaro,S. Lenhart,M. Spence,C. Drakes,G. Yang,F. Agusto,R. Johnson,B. Whitlock,A. Wadhwa,S. Eda, Modeling for cost analysis of Johne's disease control based on EVELISA testing, Journal of Biological Systems, 21 (2013): 1340010.
    [19] [ R. M. Mitchell,G. F. Medley,M. T. Collins,Y. H. Schukken, A meta-analysis of the effect of dose and age at exposure on shedding of Mycobacterium avium subsp. paratuberculosis (MAP) in experimentally infected calves and cows, Epidemiology and Infection, 140 (2012): 231-246.
    [20] [ R. M. Mitchell,Y. Schukken,A. Koets,M. Weber,D. Bakker,J. Stabel,R. H. Whitlock,Y. Louzoun, Differences in intermittent and continuous fecal shedding patterns between natural and experimental Mycobacterium avium subsp. paratuberculosis infections in cattle, Veterinary Research, 46 (2015): p66.
    [21] [ R. A. Mortier,H. W. Barkema,T. A. Wilson,T. T. Sajobi,R. Wolf,J. De Buck, Dose-dependent interferon-gamma release in dairy calves experimentally infected with Mycobacterium avium subsp. paratuberculosis, Veterinary Immunology and Immunopathology, 161 (2014): 205-210.
    [22] [ S. L. Ott,S. J. Wells,B. A. Wagner, Herd-level economic losses associated with Johne's disease on US dairy operations, Preventive Veterinary Medicine, 40 (1999): 179-192.
    [23] [ E. A. Raizman,J. Fetrow,S. J. Wells,S. M. Godden,M. J. Oakes,G. Vazquez, The association between Mycobacterium avium subsp. paratuberculosis fecal shedding or clinical \textrm{Johne's} disease and lactation performance on two Minnesota, USA dairy farms, Preventive veterinary medicine, 78 (2007): 179-195.
    [24] [ J. Robins,S. Bogen,A. Francis,A. Westhoek,A. Kanarek,S. Lenhart,S. Eda, Agent-based model for Johne's disease dynamics in a dairy herd, Veterinary Research, 46 (2015): p68.
    [25] [ H. J. W. van Roermund,D. Bakker,P. T. J. Willemsen,M. C. M. de Jong, Horizontal transmission of Mycobacterium avium subsp. paratuberculosis in cattle in an experimental setting: Calves can transmit the infection to other calves, Veterinary Microbiology, 122 (2007): 270-279.
    [26] [ A. M. Scanu,T. J. Bull,S. Cannas,J. D. Sanderson,L. A. Sechi,G. Dettori,S. Zanetti,J. H. Taylor, Mycobacterium avium subspecies paratuberculosis infection in cases of irritable bowel syndrome and comparison with Crohn's disease and Johne's disease: Common neural and immune pathogenicities, Journal of Clinical Microbiology, 45 (2007): 3883-3890.
    [27] [ M. C. Scott,J. P. Bannantine,Y. Kaneko,A. J. Branscum,R. H. Whitlock,Y. Mori,C. A. Speer,S. Eda, Absorbed EVELISA: A diagnostic test with improved specificity for Johne's disease in cattle, Foodborne Pathogens and Disease, 7 (2010): 1291-1296.
    [28] [ S. Singh,K. Gopinath, Mycobacterium avium subspecies paratuberculosis and Crohn's regional ileitis: How strong is association?, Journal of Laboratory Physicians, 3 (2011): 69-74.
    [29] [ R. L. Smith,Y. T. Gröhn,A. K. Pradhan,R. H. Whitlock,J. S. Van Kessel,J. M. Smith,D. R. Wolfgang,Y. H. Schukken, The effects of progressing and nonprogressing Mycobacterium avium subsp. paratuberculosis infection on milk production in dairy cows, Journal of Dairy Science, 99 (2016): 1383-1390.
    [30] [ J. H. Taylor, Review Mycobacterium avium subspecies paratuberculosis, Crohn's disease and the doomsday scenario, Gut Pathogens, 1 (2009): p15.
    [31] [ R. H. Whitlock, R. W. Sweeney, T. L. Fyock and J. Smith, MAP supershedders: Another factor in the control of Johne's disease, In Proceedings of the 8th International Colloquium on Paratuberculosis}(2005).
    [32] [ R. J. Whittington,I. B. Marsh,L. A. Reddacliff, Survival of Mycobacterium avium subsp. paratuberculosis in dam water and sediment, Applied and Environmental Microbiology, 71 (2005): 5304-5308.
    [33] [ R. J. Whittington,P. A. Windsor, In utero infection of cattle with Mycobacterium avium subsp. paratuberculosis: A critical review and meta-analysis, The Veterinary Journal, 179 (2009): 60-69.
    [34] [ M. Bani-Yaghoub,R. Gautam,Z. Shuai,P. van den Driessche,R. Ivanek, Reproduction numbers for infections with free-living pathogens growing in the environment, Journal of Biological Dynamics, 6 (2012): 923-940.
    [35] [ USDA. Johne's Disease on U. S. Dairies, 1991-2007, Fort Collins, CO, USA, NAHMS USDA-APHIS-VS-CEAH
    [36] [ Cow in and out game http://fergusonfoundation.org/lessons/cow_in_out/cowmoreinfo.shtml, Alice Ferguson Foundation, 2012.
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