Neural stem cell derived tumourigenesis

Francesca Froldi; Milán Szuperák; Louise Y. Cheng; Francesca Froldi; Milán Szuperák; Louise Y. Cheng

doi:10.3934/genet.2015.1.13

AIMS Genetics

2015, Volume 2, Issue 1: 13-24. doi: 10.3934/genet.2015.1.13

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Review Special Issues

Neural stem cell derived tumourigenesis

1.
Peter MacCallum Cancer Centre, East Melbourne, Victoria, 3002, Australia;
2.
Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria, 3010, Australia

Received: 23 November 2014 Accepted: 11 January 2015 Published: 13 January 2015

In the developing Drosophila CNS, two pools of neural stem cells, the symmetrically dividing progenitors in the neuroepithelium (NE) and the asymmetrically dividing neuroblasts (NBs) generate the majority of the neurons that make up the adult central nervous system (CNS). The generation of a correct sized brain depends on maintaining the fine balance between neural stem cell self-renewal and differentiation, which are regulated by cell-intrinsic and cell-extrinsic cues. In this review, we will discuss our current understanding of how self-renewal and differentiation are regulated in the two neural stem cell pools, and the consequences of the deregulation of these processes.
- Drosophila,
- stem cell,
- neuroblast,
- neuroepithelia,
- proliferation,
- differentiation,
- self-renewal
Citation: Francesca Froldi, Milán Szuperák, Louise Y. Cheng. Neural stem cell derived tumourigenesis[J]. AIMS Genetics, 2015, 2(1): 13-24. doi: 10.3934/genet.2015.1.13

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Abstract

In the developing Drosophila CNS, two pools of neural stem cells, the symmetrically dividing progenitors in the neuroepithelium (NE) and the asymmetrically dividing neuroblasts (NBs) generate the majority of the neurons that make up the adult central nervous system (CNS). The generation of a correct sized brain depends on maintaining the fine balance between neural stem cell self-renewal and differentiation, which are regulated by cell-intrinsic and cell-extrinsic cues. In this review, we will discuss our current understanding of how self-renewal and differentiation are regulated in the two neural stem cell pools, and the consequences of the deregulation of these processes.

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