Effects of the association between hydroxyapatite and photobiomodulation on bone regeneration

Jéssica de Oliveira Rossi; Gabriel Tognon Rossi; Maria Eduarda Côrtes Camargo; Rogerio Leone Buchaim; Daniela Vieira Buchaim; Jéssica de Oliveira Rossi; Gabriel Tognon Rossi; Maria Eduarda Côrtes Camargo; Rogerio Leone Buchaim; Daniela Vieira Buchaim

doi:10.3934/bioeng.2023027

AIMS Bioengineering

2023, Volume 10, Issue 4: 466-490. doi: 10.3934/bioeng.2023027

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Effects of the association between hydroxyapatite and photobiomodulation on bone regeneration

1.
Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo 05508-270, Brazil
2.
Professor of Psychiatry on the Medicine Course at the Educational Foundation of the Municipality of Assis (FEMA), Assis 19807-130, Brazil
3.
Medical Student, University of Marilia (UNIMAR), Marilia 17525-902, Brazil
4.
Department of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of Sao Paulo, Bauru 17012-901, Brazil
5.
Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marilia 17525-902, Brazil
6.
Medical School, University Center of Adamantina (UNIFAI), Adamantina 17800-000, Brazil

Received: 10 October 2023 Revised: 08 November 2023 Accepted: 16 November 2023 Published: 21 November 2023

Background
Hydroxyapatite (HA)-based ceramics are widely used as artificial bone substitutes due to their advantageous biological properties, which include biocompatibility, biological affinity, bioactivity, ability to drive bone formation, integration into bone tissue and induction of bone regeneration (in certain conditions). Phototherapy in bone regeneration is a therapeutic approach that involves the use of light to stimulate and accelerate the process of repair and regeneration of bone tissue. There are two common forms of phototherapy used for this purpose: Low-Level Laser Therapy (LLLT) and LED (Light Emitting Diode) Therapy. Understanding the mechanisms of laser therapy and its effects combined with hydroxyapatite has gaps. Therefore, this review was designed based on the PICO strategy (P: problem; I: intervention; C: control; O: result) to analyze the relationship between PBM therapy and hydroxyapatite.

Methods
The bibliographic search, with the descriptors “hydroxyapatite AND low-level laser therapy” and “hydroxyapatite AND photobiomodulation” resulted in 43 articles in the PubMed/MEDLINE database, of which 1 was excluded for being a duplicate and another 33 due to inclusion/exclusion criteria, totaling 9 articles for qualitative analysis. In the Web of Science database, we obtained 40 articles, of which 7 were excluded for being duplicates, 1 for not having the full text available and another 17 due to inclusion/exclusion criteria, totaling 15 articles for qualitative analysis.

Results
The most used biomaterial was composed of hydroxyapatite and β-tricalcium phosphate in a proportion of 70%–30%. In photobiomodulation, the gallium-aluminum-arsenide (GaAlAs) laser prevailed, with a wavelength of 780 nm, followed by 808 nm.

Conclusions
The results indicated that the use of laser phototherapy improved the repair of bone defects grafted with the biomaterial, increasing the deposition of HA phosphate as indicated by biochemical estimators, spectroscopy and histological analyses.
- low-level laser therapy,
- hydroxyapatite,
- bone regeneration,
- photobiomodulation,
- bone repair
Citation: Jéssica de Oliveira Rossi, Gabriel Tognon Rossi, Maria Eduarda Côrtes Camargo, Rogerio Leone Buchaim, Daniela Vieira Buchaim. Effects of the association between hydroxyapatite and photobiomodulation on bone regeneration[J]. AIMS Bioengineering, 2023, 10(4): 466-490. doi: 10.3934/bioeng.2023027

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Abstract

Background

Hydroxyapatite (HA)-based ceramics are widely used as artificial bone substitutes due to their advantageous biological properties, which include biocompatibility, biological affinity, bioactivity, ability to drive bone formation, integration into bone tissue and induction of bone regeneration (in certain conditions). Phototherapy in bone regeneration is a therapeutic approach that involves the use of light to stimulate and accelerate the process of repair and regeneration of bone tissue. There are two common forms of phototherapy used for this purpose: Low-Level Laser Therapy (LLLT) and LED (Light Emitting Diode) Therapy. Understanding the mechanisms of laser therapy and its effects combined with hydroxyapatite has gaps. Therefore, this review was designed based on the PICO strategy (P: problem; I: intervention; C: control; O: result) to analyze the relationship between PBM therapy and hydroxyapatite.

Methods

The bibliographic search, with the descriptors “hydroxyapatite AND low-level laser therapy” and “hydroxyapatite AND photobiomodulation” resulted in 43 articles in the PubMed/MEDLINE database, of which 1 was excluded for being a duplicate and another 33 due to inclusion/exclusion criteria, totaling 9 articles for qualitative analysis. In the Web of Science database, we obtained 40 articles, of which 7 were excluded for being duplicates, 1 for not having the full text available and another 17 due to inclusion/exclusion criteria, totaling 15 articles for qualitative analysis.

Results

The most used biomaterial was composed of hydroxyapatite and β-tricalcium phosphate in a proportion of 70%–30%. In photobiomodulation, the gallium-aluminum-arsenide (GaAlAs) laser prevailed, with a wavelength of 780 nm, followed by 808 nm.

Conclusions

The results indicated that the use of laser phototherapy improved the repair of bone defects grafted with the biomaterial, increasing the deposition of HA phosphate as indicated by biochemical estimators, spectroscopy and histological analyses.

Conflict of interest

The authors declare no conflicts of interest.

Author Contributions:

Conceptualization, J.d.O.R. and D.V.B.; Methodology, ,J.d.O.R and G.T.R.; Formal Analysis, J.d.O.R. and D.V.B.; Investigation, J.d.O.R. and R.L.B; Data Curation, M.E.C.C.; Writing–Original Draft Preparation, J.d.O.R. and D.V.B.; Writing–Review and Editing, J.d.O.R.; D.V.B., D.V.B. and R.L.B.; Visualization, J.d.O.R.; R.L.B.; Supervision, D.V.B. All authors have read and agreed to the published version of the manuscript.

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