The association between nicotinamide N-methyltransferase gene polymorphisms and primary hypertension in Chinese Han Population

Xiang-Xiang Guan; Xiao-Juan Zhu; Zhao-Hui Deng; Yu-Rong Zeng; Jie-Ru Liu; Jiang-Hua Li; Xiang-Xiang Guan; Xiao-Juan Zhu; Zhao-Hui Deng; Yu-Rong Zeng; Jie-Ru Liu; Jiang-Hua Li

doi:10.3934/bioeng.2021012

AIMS Bioengineering

2021, Volume 8, Issue 2: 130-139. doi: 10.3934/bioeng.2021012

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The association between nicotinamide N-methyltransferase gene polymorphisms and primary hypertension in Chinese Han Population

Department Key Lab of Aquatic Training Monitoring and Intervention of General Administration of Sport of China, Physical Education College, Jiangxi Normal University, Nanchang 330022, Jiangxi Province, China

Received: 07 January 2021 Accepted: 19 February 2021 Published: 03 March 2021

Although no direct evidence shows that Nicotinamide N-methyltransferase (NNMT) is involved in hypertension to date, many reports have shown that NNMT plays important roles in pathogenesis of metabolic syndrome and in various cardiovascular diseases. Here we explored the genetic association between NNMT polymorphisms and primary hypertension. 308 primary hypertension cases (aged < 60 years, blood pressure ≥ 140/90 mmHg or taking antihypertensive therapies) and 315 controls (aged ≥ 60 years and without any diagnosed diseases) were recruited from unrelated Chinese Han ethnicity volunteers. Then a case-control study was carried out to explore the genetic association between NNMT polymorphism and primary hypertension. A significantly associated SNP (rs1941404) was found in NNMT gene (P < 0.0125). At this locus, the risks for minor homozygote CC carriers being of hypertension were highly significantly higher than those for the TT + CT carriers (OR = 2.120, OR_adjusted = 2.573, P = 0.000, P_adjusted = 0.001 and statistical power = 0.997), but the differences between the genotypes CT + CC and TT (dominant genetic model) were not statistically significant (P = 0.321, P_adjusted = 0.230 and statistical power = 0.200). In conclusion, rs1941404 in NNMT gene sequence is significantly associated with primary hypertension under a recessive inheritance mode. At this locus, the minor homozygote CC carriers are susceptible population and the TT and CT carriers are non-susceptible population.
- nicotinamide N-methyltransferase (NNMT),
- cardiovascular diseases,
- obesity,
- metabolic syndrome,
- diabetes,
- hyperhomocysteinemia
Citation: Xiang-Xiang Guan, Xiao-Juan Zhu, Zhao-Hui Deng, Yu-Rong Zeng, Jie-Ru Liu, Jiang-Hua Li. The association between nicotinamide N-methyltransferase gene polymorphisms and primary hypertension in Chinese Han Population[J]. AIMS Bioengineering, 2021, 8(2): 130-139. doi: 10.3934/bioeng.2021012

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Abstract

Although no direct evidence shows that Nicotinamide N-methyltransferase (NNMT) is involved in hypertension to date, many reports have shown that NNMT plays important roles in pathogenesis of metabolic syndrome and in various cardiovascular diseases. Here we explored the genetic association between NNMT polymorphisms and primary hypertension. 308 primary hypertension cases (aged < 60 years, blood pressure ≥ 140/90 mmHg or taking antihypertensive therapies) and 315 controls (aged ≥ 60 years and without any diagnosed diseases) were recruited from unrelated Chinese Han ethnicity volunteers. Then a case-control study was carried out to explore the genetic association between NNMT polymorphism and primary hypertension. A significantly associated SNP (rs1941404) was found in NNMT gene (P < 0.0125). At this locus, the risks for minor homozygote CC carriers being of hypertension were highly significantly higher than those for the TT + CT carriers (OR = 2.120, OR_adjusted = 2.573, P = 0.000, P_adjusted = 0.001 and statistical power = 0.997), but the differences between the genotypes CT + CC and TT (dominant genetic model) were not statistically significant (P = 0.321, P_adjusted = 0.230 and statistical power = 0.200). In conclusion, rs1941404 in NNMT gene sequence is significantly associated with primary hypertension under a recessive inheritance mode. At this locus, the minor homozygote CC carriers are susceptible population and the TT and CT carriers are non-susceptible population.

Acknowledgments

This investigation was supported by the National Science Foundation of China (21365013), the higher education reform research project of Jiangxi Province (JXJG-18-2-41) and the Key Lab of Aquatic Training Monitoring and Intervention of General Administration of Sport of China (201901).

Conflict of interest

The authors declare no conflict of interest.

Author contributions

Xiang-Xiang Guan: investigation, evaluation, and writing; Xiao-Juan Zhu: investigation; Zhao-Hui Deng: investigation; Yu-Rong Zeng: investigation; Jie-Ru Liu: investigation; Jiang-Hua Li: investigation, evaluation, conceptualization, and writing.

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